Genetic Abnormalities of the Sinoatrial Node and Atrioventricular Conduction.
Arrhythmia
Atrioventricular node
Electrophysiology
Inherited arrhythmias
Sinoatrial node dysfunction
Journal
Cardiology clinics
ISSN: 1558-2264
Titre abrégé: Cardiol Clin
Pays: Netherlands
ID NLM: 8300331
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
medline:
19
6
2023
pubmed:
16
6
2023
entrez:
15
6
2023
Statut:
ppublish
Résumé
The peculiar electrophysiological properties of the sinoatrial node and the cardiac conduction system are key components of the normal physiology of cardiac impulse generation and propagation. Multiple genes and transcription factors and metabolic proteins are involved in their development and regulation. In this review, we have summarized the genetic underlying causes, key clinical findings, and the latest available clinical evidence. We will discuss clinical diagnosis and management of the genetic conditions associated with conduction disorders that are more prevalent in clinical practice, for this reason, very rare genetic diseases presenting sinus node or cardiac conduction system abnormalities are not discussed.
Identifiants
pubmed: 37321685
pii: S0733-8651(23)00040-1
doi: 10.1016/j.ccl.2023.03.014
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
333-347Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.