Glycine: a long-sought novel ligand for GPR158.

Humans Ligands Glycine / pharmacology Receptors, G-Protein-Coupled
GPR158 class C GPCRs glycine metabotropic receptor

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
Aug 2023
Historique:
received: 09 05 2023
revised: 21 05 2023
accepted: 22 05 2023
medline: 17 7 2023
pubmed: 16 6 2023
entrez: 15 6 2023
Statut: ppublish

Résumé

G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.

Identifiants

DOI: 10.1016/j.tips.2023.05.004 PMID: 37321907
pubmed: 37321907
pii: S0165-6147(23)00109-8
doi: 10.1016/j.tips.2023.05.004
pii:
doi:

Substances chimiques

Ligands 0
Glycine TE7660XO1C
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

489-491

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no conflicts of interest.

Auteurs

Mette Marie Rosenkilde (MM)

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: rosenkilde@sund.ku.dk.

Jesper Mosolff Mathiesen (JM)

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Electronic address: jmm@sund.ku.dk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Glycine: a long-sought novel ligand for GPR158.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Glycine: a long-sought novel ligand for GPR158.
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Glycine › Glycine: a long-sought novel ligand for GPR158.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Glycine: a long-sought novel ligand for GPR158.