Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study.
Brain injury
Critically ill
Hyperoxemia
Hyperoxia
Outcome
Oxygen
Journal
Neurocritical care
ISSN: 1556-0961
Titre abrégé: Neurocrit Care
Pays: United States
ID NLM: 101156086
Informations de publication
Date de publication:
15 Jun 2023
15 Jun 2023
Historique:
received:
18
01
2023
accepted:
16
05
2023
medline:
16
6
2023
pubmed:
16
6
2023
entrez:
15
6
2023
Statut:
aheadofprint
Résumé
In acute brain injury (ABI), the effects of hypoxemia as a potential cause of secondary brain damage and poor outcome are well documented, whereas the impact of hyperoxemia is unclear. The primary aim of this study was to assess the episodes of hypoxemia and hyperoxemia in patients with ABI during the intensive care unit (ICU) stay and to determine their association with in-hospital mortality. The secondary aim was to identify the optimal thresholds of arterial partial pressure of oxygen (PaO We conducted a secondary analysis of a prospective multicenter observational cohort study. Adult patients with ABI (traumatic brain injury, subarachnoid aneurysmal hemorrhage, intracranial hemorrhage, ischemic stroke) with available data on PaO A total of 1,407 patients were included in this study. The mean age was 52 (±18) years, and 929 (66%) were male. Over the ICU stay, the fractions of patients in the study cohort who had at least one episode of hypoxemia, mild/moderate hyperoxemia, and severe hyperoxemia were 31.3%, 53.0%, and 1.7%, respectively. PaO In patients with ABI, hypoxemia and mild/moderate hyperoxemia were relatively frequent. Hypoxemia and hyperoxemia during ICU stay may influence in-hospital mortality. However, the small number of oxygen values collected represents a major limitation of the study.
Sections du résumé
BACKGROUND
BACKGROUND
In acute brain injury (ABI), the effects of hypoxemia as a potential cause of secondary brain damage and poor outcome are well documented, whereas the impact of hyperoxemia is unclear. The primary aim of this study was to assess the episodes of hypoxemia and hyperoxemia in patients with ABI during the intensive care unit (ICU) stay and to determine their association with in-hospital mortality. The secondary aim was to identify the optimal thresholds of arterial partial pressure of oxygen (PaO
METHODS
METHODS
We conducted a secondary analysis of a prospective multicenter observational cohort study. Adult patients with ABI (traumatic brain injury, subarachnoid aneurysmal hemorrhage, intracranial hemorrhage, ischemic stroke) with available data on PaO
RESULTS
RESULTS
A total of 1,407 patients were included in this study. The mean age was 52 (±18) years, and 929 (66%) were male. Over the ICU stay, the fractions of patients in the study cohort who had at least one episode of hypoxemia, mild/moderate hyperoxemia, and severe hyperoxemia were 31.3%, 53.0%, and 1.7%, respectively. PaO
CONCLUSIONS
CONCLUSIONS
In patients with ABI, hypoxemia and mild/moderate hyperoxemia were relatively frequent. Hypoxemia and hyperoxemia during ICU stay may influence in-hospital mortality. However, the small number of oxygen values collected represents a major limitation of the study.
Identifiants
pubmed: 37322325
doi: 10.1007/s12028-023-01761-x
pii: 10.1007/s12028-023-01761-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Paër-Sélim Abback
(PS)
Anaïs Codorniu
(A)
Giuseppe Citerio
(G)
Vittoria Ludovica Sala
(VL)
Marinella Astuto
(M)
Eleonora Tringali
(E)
Daniela Alampi
(D)
Monica Rocco
(M)
Jessica Giuseppina Maugeri
(JG)
Bellissima Agrippino
(B)
Matteo Filippini
(M)
Nicoletta Lazzeri
(N)
Andrea Cortegiani
(A)
Mariachiara Ippolito
(M)
Chiara Robba
(C)
Denise Battaglini
(D)
Patrick Biston
(P)
Mohamed Fathi Al-Gharyani
(MF)
Russell Chabanne
(R)
Léo Astier
(L)
Benjamin Soyer
(B)
Samuel Gaugain
(S)
Alice Zimmerli
(A)
Urs Pietsch
(U)
Miodrag Filipovic
(M)
Giovanna Brandi
(G)
Giulio Bicciato
(G)
Ainhoa Serrano
(A)
Berta Monleon
(B)
Peter van Vliet
(P)
Benjamin Marcel Gerretsen
(BM)
Iris Xochitl Ortiz-Macias
(IX)
Jun Oto
(J)
Noriya Enomoto
(N)
Tomomichi Matsuda
(T)
Nobutaka Masui
(N)
Pierre Garçon
(P)
Jonathan Zarka
(J)
Wytze J Vermeijden
(WJ)
Alexander Daniel Cornet
(AD)
Sergio Reyes Inurrigarro
(SR)
Rafael Cirino Lara Domínguez
(RCL)
Maria Mercedes Bellini
(MM)
Maria Milagros Gomez-Haedo
(MM)
Laura Lamot
(L)
Jose Orquera
(J)
Matthieu Biais
(M)
Delphine Georges
(D)
Arvind Baronia
(A)
Roberto Carlos Miranda-Ackerman
(RC)
Francisco José Barbosa-Camacho
(FJ)
John Porter
(J)
Miguel Lopez-Morales
(M)
Thomas Geeraerts
(T)
Baptiste Compagnon
(B)
David Pérez-Torres
(D)
Estefanía Prol-Silva
(E)
Hana Basheer Yahya
(HB)
Ala Khaled
(A)
Mohamed Ghula
(M)
Andrea Cracchiolo Neville
(A)
Maria Daniela Palma
(MD)
Cristian Deana
(C)
Luigi Vetrugno
(L)
Manuel J Rivera Chavez
(MJR)
Rocio Mendoza Trujillo
(RM)
Vincent Legros
(V)
Benjamin Brochet
(B)
Olivier Huet
(O)
Marie Geslain
(M)
Mathieu van der Jagt
(M)
Job van Steenkiste
(J)
Hazem Ahmed
(H)
Alexander Edward Coombs
(AE)
Jessie Welbourne
(J)
Ana Alicia Velarde Pineda
(AAV)
Víctor Hugo Nubert Castillo
(VHN)
Mohammed A Azab
(MA)
Ahmed Y Azzam
(AY)
David Michael Paul van Meenen
(DMP)
Gilberto Adrian Gasca
(GA)
Alfredo Arellano
(A)
Forttino Galicia-Espinosa
(F)
José Carlos García-Ramos
(JC)
Ghanshyam Yadav
(G)
Amarendra Kumar Jha
(AK)
Vincent Robert-Edan
(V)
Pierre-Andre Rodie-Talbere
(PA)
Gaurav Jain
(G)
Sagarika Panda
(S)
Sonika Agarwal
(S)
Yashbir Deewan
(Y)
Gilberto Adrian Gasca
(GA)
Alfredo Arellano
(A)
Syed Tariq Reza
(ST)
Md Mozaffer Hossain
(MM)
Christos Papadas
(C)
Vasiliki Chantziara
(V)
Chrysanthi Sklavou
(C)
Yannick Hourmant
(Y)
Nicolas Grillot
(N)
Job van Steenkiste
(J)
Mathieu van der Jagt
(M)
Romain Pirracchio
(R)
Abdelraouf Akkari
(A)
Mohamed Abdelaty
(M)
Ahmed Hashim
(A)
Yoann Launey
(Y)
Elodie Masseret
(E)
Sigismond Lasocki
(S)
Soizic Gergaud
(S)
Nicolas Mouclier
(N)
Sulekha Saxena
(S)
Avinash Agrawal
(A)
Shakti Bedanta Mishra
(SB)
Samir Samal
(S)
Julio Cesar Mijangos
(JC)
Mattias Haënggi
(M)
Mohan Gurjar
(M)
Mohan Gurjar
(M)
Marcus J Schultz
(MJ)
Callum Kaye
(C)
Daniela Agustin Godoy
(DA)
Pablo Alvarez
(P)
Aikaterini Ioakeimidou
(A)
Yoshitoyo Ueno
(Y)
Rafael Badenes
(R)
Abdurrahmaan Ali Suei Elbuzidi
(AAS)
Michaël Piagnerelli
(M)
Muhammed Elhadi
(M)
Syed Tariq Reza
(ST)
Mohammed Atef Azab
(MA)
Jean Catherine Digitale
(JC)
Nicholas Fong
(N)
Ricardo Campos Cerda
(RC)
Norma de la Torre Peredo
(N)
Informations de copyright
© 2023. Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society.
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