Fluoroquinolone Use Among Hospitalized Children: Diagnosis-Based Stratification to Identify Stewardship Targets.
antimicrobial stewardship
cystic fibrosis
fluoroquinolones
hospitalized children
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
07
04
2023
accepted:
26
05
2023
medline:
16
6
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
epublish
Résumé
As FQ (fluoroquinolone) use has shifted in pediatric populations, better metrics are needed to guide targeted antibiotic stewardship interventions and limit development of adverse events and resistance, particularly in medically complex children. In this study, we identify high-utilization groups based on underlying medical conditions and describe their relative FQ use over time. This study is a retrospective analysis of data from the Pediatric Health Information System database from 2016 to 2020. We identify high-utilization groups based on underlying medical conditions using Patients with an oncology diagnosis represent a large (25%-44%) and rising proportion (+4.8%/year, Patients with an oncology diagnosis and patients with an intra-abdominal infection appear to be targets for FQ stewardship. Patients with cystic fibrosis have decreasing inpatient FQ use.
Sections du résumé
Background
UNASSIGNED
As FQ (fluoroquinolone) use has shifted in pediatric populations, better metrics are needed to guide targeted antibiotic stewardship interventions and limit development of adverse events and resistance, particularly in medically complex children. In this study, we identify high-utilization groups based on underlying medical conditions and describe their relative FQ use over time.
Methods
UNASSIGNED
This study is a retrospective analysis of data from the Pediatric Health Information System database from 2016 to 2020. We identify high-utilization groups based on underlying medical conditions using
Results
UNASSIGNED
Patients with an oncology diagnosis represent a large (25%-44%) and rising proportion (+4.8%/year,
Conclusions
UNASSIGNED
Patients with an oncology diagnosis and patients with an intra-abdominal infection appear to be targets for FQ stewardship. Patients with cystic fibrosis have decreasing inpatient FQ use.
Identifiants
pubmed: 37323425
doi: 10.1093/ofid/ofad297
pii: ofad297
pmc: PMC10264067
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofad297Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Déclaration de conflit d'intérêts
Potential conflicts of interest. All authors: No reported conflicts.
Références
Clin Infect Dis. 2015 May 1;60(9):1389-97
pubmed: 25595742
Pediatr Infect Dis J. 2019 Mar;38(3):268-270
pubmed: 29846302
Am J Surg. 1994 Mar;167(3):313-6
pubmed: 8160904
Antimicrob Agents Chemother. 2009 Mar;53(3):1287-9
pubmed: 19064895
JAMA. 2018 Sep 11;320(10):995-1004
pubmed: 30208456
Stat Med. 2017 Sep 10;36(20):3257-3277
pubmed: 28543517
Infect Control Hosp Epidemiol. 2019 Apr;40(4):447-456
pubmed: 30837029
Antimicrob Resist Infect Control. 2021 Aug 11;10(1):118
pubmed: 34380549
Ann Allergy Asthma Immunol. 2021 Oct;127(4):456-461
pubmed: 34048884
J Clin Oncol. 2023 Mar 20;41(9):1774-1785
pubmed: 36689694
Lancet Microbe. 2021 Apr;2(4):e159-e167
pubmed: 34355208
Infect Control Hosp Epidemiol. 2018 Dec;39(12):1473-1475
pubmed: 30303060
Emerg Infect Dis. 2016 Sep;22(9):
pubmed: 27532362
N Engl J Med. 2019 Nov 7;381(19):1809-1819
pubmed: 31697873
J Cyst Fibros. 2014 Mar;13(2):205-11
pubmed: 24169544
Clin Infect Dis. 2021 Nov 2;73(9):1589-1596
pubmed: 34100912
J Clin Pharmacol. 2016 Sep;56(9):1060-75
pubmed: 26865283
Arch Med Sci. 2019 May;15(3):688-693
pubmed: 31110535
Clin Infect Dis. 2021 Oct 5;73(7):1257-1265
pubmed: 33956965
J Clin Oncol. 2018 Oct 20;36(30):3043-3054
pubmed: 30179565
Clin Infect Dis. 2022 Aug 24;75(1):178-179
pubmed: 34864924
Ann Surg. 2021 Sep 1;274(3):406-410
pubmed: 34132703
J Pediatr Surg. 2022 Oct;57(10):365-372
pubmed: 34876294
J Pediatric Infect Dis Soc. 2021 May 28;10(5):576-585
pubmed: 33377490
Pediatr Infect Dis J. 2014 Jun;33(6):e158-61
pubmed: 24830523
Infect Dis Clin North Am. 2018 Mar;32(1):1-17
pubmed: 29406971
Clin Ther. 2021 Oct;43(10):1681-1688
pubmed: 34645574
Pediatrics. 2016 Jul;138(1):
pubmed: 27354453
Pediatrics. 2016 Nov;138(5):
pubmed: 27940800
J Pediatr Surg. 1999 May;34(5):749-53
pubmed: 10359176
PLoS One. 2017 Jan 31;12(1):e0171216
pubmed: 28141845
Clin Infect Dis. 2017 Nov 13;65(11):1790-1798
pubmed: 29020310