Sex differences in olfactory cortex neuronal loss in aging.
aging
atrophy
neuroimaging
neuronal loss
olfactory cortex
sex
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
12
2022
accepted:
28
03
2023
medline:
16
6
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
epublish
Résumé
Aging plays a major role in neurodegenerative disorders such as Alzheimer's disease, and impacts neuronal loss. Olfactory dysfunction can be an early alteration heralding the presence of a neurodegenerative disorder in aging. Studying alterations in olfaction-related brain regions might help detection of neurodegenerative diseases at an earlier stage as well as protect individuals from any danger caused by loss of sense of smell. To assess the effect of age and sex on olfactory cortex volume in cognitively healthy participants. Neurologically healthy participants were divided in three groups based on their age: young (20-35 years; ANCOVA analyses showed significant differences in volume between age groups in the olfactory cortex ( Data indicate that age-related reduction in the volume of the olfactory cortex starts earlier in women than in men. The findings suggest that volume changes in olfaction-related brain regions in the aging population deserve further attention as potential proxies of increased risk of neurodegenerative diseases.
Identifiants
pubmed: 37323926
doi: 10.3389/fnhum.2023.1130200
pmc: PMC10265738
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1130200Informations de copyright
Copyright © 2023 Alotaibi, De Marco and Venneri.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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