Enhanced external counter pulsation therapy in patients with symptomatic and severe intracranial steno-occlusive disease: a randomized clinical trial protocol.
cerebral vasodilatory reserve
enhanced external counter pulsation (EECP)
intracranial stenosis
ischemic stroke
transcranial Doppler
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
03
2023
accepted:
02
05
2023
medline:
16
6
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
epublish
Résumé
Intracranial stenosis is prevalent among Asians and constitutes a common cause of cerebral ischemia. While the best medical therapy carries stroke recurrence rates in excess of 10% per year, trials with intracranial stenting have been associated with unacceptable peri-procedural ischemic events. Cerebral ischemic events are strongly related to the severity of intracranial stenosis, which is high in patients with severe intracranial stenosis with poor vasodilatory reserve. Enhanced External Counter Pulsation (EECP) therapy is known to improve myocardial perfusion by facilitating the development of collateral blood vessels in the heart. In this randomized clinical trial, we evaluate whether EECP therapy may be useful in patients with severe stenosis of intracranial internal carotid (ICA) or middle cerebral artery (MCA). The review of literature, methods of evaluation, status of currently used therapeutic approaches, and trial protocol have been presented. ClinicalTrials.gov, Identifier: NCT03921827.
Identifiants
pubmed: 37325226
doi: 10.3389/fneur.2023.1177500
pmc: PMC10262049
doi:
Banques de données
ClinicalTrials.gov
['NCT03921827']
Types de publication
Journal Article
Langues
eng
Pagination
1177500Informations de copyright
Copyright © 2023 Sharma, Gopinathan, Tan, Loh, Hung, Tang, Chua, Chan, Ong, Chin, Jing, Goh, Sunny, Keat, Ka, Pandya, Wong, Chen, Yeo, Chan, Teoh and Sinha.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
N Engl J Med. 2013 Jul 4;369(1):11-9
pubmed: 23803136
N Engl J Med. 2018 Jul 19;379(3):215-225
pubmed: 29766750
AJNR Am J Neuroradiol. 2016 Jul;37(7):1275-80
pubmed: 26869472
J Neurol Neurosurg Psychiatry. 1965 Oct;28(5):449-52
pubmed: 5838479
BMJ. 2004 Feb 7;328(7435):326
pubmed: 14744823
J Am Coll Cardiol. 2003 Jun 4;41(11):1918-25
pubmed: 12798558
J Cereb Blood Flow Metab. 2018 Apr;38(4):603-626
pubmed: 29168667
Stroke. 1998 Mar;29(3):725-9
pubmed: 9506619
J Neurol Sci. 2012 Nov 15;322(1-2):112-6
pubmed: 22846792
Cerebrovasc Dis. 2012;33(6):517-24
pubmed: 22538868
JAMA. 2000 Apr 26;283(16):2122-7
pubmed: 10791504
Clin Cardiol. 2002 Dec;25(12 Suppl 2):II16-21
pubmed: 12489599
Neurol Res. 1986 Dec;8(4):231-6
pubmed: 2880314
Circulation. 2006 Jan 31;113(4):555-63
pubmed: 16432056
Stroke. 1996 Nov;27(11):1974-80
pubmed: 8898801
Radiology. 2010 Jul;256(1):201-8
pubmed: 20574097
Am J Cardiol. 1999 Oct 15;84(8):950-2, A7-8
pubmed: 10532522
J Neurol Sci. 2010 Dec 15;299(1-2):15-8
pubmed: 20889166
J Vasc Interv Neurol. 2008 Oct;1(4):96-101
pubmed: 22518232
J Cerebrovasc Endovasc Neurosurg. 2020 Dec;22(4):216-224
pubmed: 33050686
Lancet. 1984 Feb 11;1(8372):310-4
pubmed: 6141382
Acta Neurol Scand Suppl. 1988;114:1-48
pubmed: 3259361
J Cereb Blood Flow Metab. 1994 Sep;14(5):763-70
pubmed: 8063872
JAMA. 2000 Dec 13;284(22):2901-6
pubmed: 11147987
Neurology. 1990 Oct;40(10):1541-5
pubmed: 2215945
N Engl J Med. 1985 Nov 7;313(19):1191-200
pubmed: 2865674
Stroke. 2007 May;38(5):1531-7
pubmed: 17395864
Stroke. 2007 Dec;38(12):3175-81
pubmed: 17947595
N Engl J Med. 2011 Sep 15;365(11):993-1003
pubmed: 21899409
Stroke. 2014 Jul;45(7):2160-236
pubmed: 24788967
Cardiology. 2003;100(3):129-35
pubmed: 14631133
Stroke. 2008 Aug;39(8):2396-9
pubmed: 18535283
Neurology. 1995 Aug;45(8):1488-93
pubmed: 7644046
Lancet. 1997 May 31;349(9065):1569-81
pubmed: 9174558
AJNR Am J Neuroradiol. 2017 Apr;38(4):703-711
pubmed: 28183839
Lancet. 1997 Jun 7;349(9066):1641-9
pubmed: 9186381
Lancet Neurol. 2010 May;9(5):489-97
pubmed: 20335070
Stroke. 2007 Nov;38(11):3045-8
pubmed: 17916768
Stroke. 2007 Mar;38(3):881-7
pubmed: 17290030
J Neurol Neurosurg Psychiatry. 2013 Aug;84(8):893-900
pubmed: 23457225
Neurology. 2008 Apr 22;70(17):1518-24
pubmed: 18235078
Neurology. 2004 Jul 13;63(1):27-32
pubmed: 15249606
AJNR Am J Neuroradiol. 2001 May;22(5):928-36
pubmed: 11337339
Circulation. 2005 May 3;111(17):2233-40
pubmed: 15851601
Neurology. 2004 Jun 8;62(11):2015-20
pubmed: 15184607
Stroke. 2008 Oct;39(10):2760-4
pubmed: 18658038
Brain. 1997 Apr;120 ( Pt 4):621-9
pubmed: 9153124
Ann Neurol. 2011 Jun;69(6):963-74
pubmed: 21437932
Ann Acad Med Singap. 2008 May;37(5):402-5
pubmed: 18536827
Stroke. 2005 May;36(5):971-5
pubmed: 15817897
N Engl J Med. 1984 Jul 5;311(1):27-34
pubmed: 6374458
BMJ Open. 2013 Jun 20;3(6):
pubmed: 23794561
J Neurosurg. 2013 Jan;118(1):25-33
pubmed: 23101451
J Neurosurg. 2015 Sep;123(3):662-9
pubmed: 26023999
Clin Neurol Neurosurg. 2018 Jun;169:149-153
pubmed: 29673881
J Cardiovasc Manag. 2002 Nov-Dec;13(6):20-5
pubmed: 12500419
JAMA. 2015 Mar 24-31;313(12):1240-8
pubmed: 25803346
Int J Stroke. 2006 Aug;1(3):158-9
pubmed: 18706036
Stroke. 2019 Apr;50(4):889-894
pubmed: 31125298
Hunan Yi Ke Da Xue Xue Bao. 2000 Feb 28;25(1):45-7
pubmed: 12212245
Ann Intern Med. 1987 Jan;106(1):27-34
pubmed: 3491558
Am J Cardiol. 2000 Nov 15;86(10):1139-41, A9
pubmed: 11074215
Stroke. 1992 May;23(5):668-73
pubmed: 1579964