PPAR
Journal
PPAR research
ISSN: 1687-4757
Titre abrégé: PPAR Res
Pays: United States
ID NLM: 101269101
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
11
2022
revised:
01
05
2023
accepted:
17
05
2023
medline:
16
6
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
epublish
Résumé
Type 2 diabetes is characterized by reduced insulin sensitivity, elevated blood metabolites, and reduced mitochondrial metabolism with reduced expression of genes governing metabolism such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 C2C12 myotubes were treated with GW501516 (GW) for up to 24 hours. Mitochondrial and glycolytic metabolism were measured via oxygen consumption and extracellular acidification rate, respectively. Metabolic gene and protein expression were assessed via quantitative real-time polymerase chain reaction (qRT-PCR) and western blot, respectively. Media BCAA content was assessed via liquid chromatography-mass spectrometry (LC/MS). GW significantly increased PGC-1 These data confirm the ability of GW to increase muscle PGC-1
Sections du résumé
Background
UNASSIGNED
Type 2 diabetes is characterized by reduced insulin sensitivity, elevated blood metabolites, and reduced mitochondrial metabolism with reduced expression of genes governing metabolism such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1
Methods
UNASSIGNED
C2C12 myotubes were treated with GW501516 (GW) for up to 24 hours. Mitochondrial and glycolytic metabolism were measured via oxygen consumption and extracellular acidification rate, respectively. Metabolic gene and protein expression were assessed via quantitative real-time polymerase chain reaction (qRT-PCR) and western blot, respectively. Media BCAA content was assessed via liquid chromatography-mass spectrometry (LC/MS).
Results
UNASSIGNED
GW significantly increased PGC-1
Conclusion
UNASSIGNED
These data confirm the ability of GW to increase muscle PGC-1
Identifiants
pubmed: 37325367
doi: 10.1155/2023/4779199
pmc: PMC10264138
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4779199Informations de copyright
Copyright © 2023 Caroline N. Rivera et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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