A dynamic covalent polymeric antimicrobial for conquering drug-resistant bacterial infection.
antimicrobials
combination therapy
micelles
multidrug resistance
phenylboronic acid
Journal
Exploration (Beijing, China)
ISSN: 2766-2098
Titre abrégé: Exploration (Beijing)
Pays: China
ID NLM: 9918383883006676
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
23
12
2021
accepted:
27
04
2022
medline:
16
6
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
epublish
Résumé
Increasing bacterial drug resistance to antibiotics has posed a major threat to contemporary public health, which resulted in a large number of people suffering from serious infections and ending up dying without any effective therapies every year. Here, a dynamic covalent polymeric antimicrobial, based on phenylboronic acid (PBA)-installed micellar nanocarriers incorporating clinical vancomycin and curcumin, is developed to overcome drug-resistant bacterial infections. The formation of this antimicrobial is facilitated by reversible dynamic covalent interactions between PBA moieties in polymeric micelles and diols in vancomycin, which impart favorable stability in blood circulation and excellent acid-responsiveness in the infection microenvironment. Moreover, the structurally similar aromatic vancomycin and curcumin molecules can afford π-π stacking interaction to realize simultaneous delivery and release of payloads. In comparison with monotherapy, this dynamic covalent polymeric antimicrobial demonstrated more significant eradication of drug-resistant bacteria in vitro and in vivo due to the synergism of the two drugs. Furthermore, the achieved combination therapy shows satisfied biocompatibility without unwanted toxicity. Considering various antibiotics contain diol and aromatic structures, this simple and robust strategy can become a universal platform to combat the ever-threatening drug-resistant infectious diseases.
Identifiants
pubmed: 37325499
doi: 10.1002/EXP.20210145
pii: EXP20210145
pmc: PMC10191036
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20210145Informations de copyright
© 2022 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Int J Mol Sci. 2021 Jan 16;22(2):
pubmed: 33467089
Chem Biodivers. 2020 Aug;17(8):e2000171
pubmed: 32533635
Biomater Sci. 2018 May 29;6(6):1526-1534
pubmed: 29666858
Clin Infect Dis. 2017 Aug 15;65(suppl_1):S58-S63
pubmed: 28859341
Biomater Sci. 2015 Jul;3(7):1134-46
pubmed: 26221946
Eur J Med Chem. 2019 Feb 1;163:527-545
pubmed: 30553144
Lancet. 2014 May 3;383(9928):1572-9
pubmed: 24671080
J Am Chem Soc. 2018 Jan 31;140(4):1235-1238
pubmed: 29332390
Biomacromolecules. 2013 Oct 14;14(10):3434-43
pubmed: 24063314
Nature. 2017 Feb 28;543(7643):15
pubmed: 28252092
J Trop Med. 2016;2016:2853045
pubmed: 27956904
J Am Chem Soc. 2015 Mar 18;137(10):3458-61
pubmed: 25741752
Clin Infect Dis. 2009 Oct 1;49(7):1072-9
pubmed: 19725789
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:255-263
pubmed: 30889699
Nat Rev Immunol. 2010 Mar;10(3):170-81
pubmed: 20154735
J Pathog. 2016;2016:4065603
pubmed: 26942013
Biomaterials. 2015 Dec;71:1-10
pubmed: 26310358
ACS Nano. 2016 Apr 26;10(4):4779-89
pubmed: 26998731
ACS Appl Mater Interfaces. 2020 Feb 5;12(5):5488-5499
pubmed: 31927982
Biomater Sci. 2020 Feb 7;8(3):949-959
pubmed: 31840696
J Med Chem. 2017 Mar 23;60(6):2425-2438
pubmed: 28248504
J Adv Res. 2019 Oct 12;21:169-176
pubmed: 32071785
Expert Opin Drug Saf. 2015 Apr;14(4):571-82
pubmed: 25630559
Sci Rep. 2020 Jul 29;10(1):12689
pubmed: 32728110
Angew Chem Int Ed Engl. 2012 May 29;51(22):5308-32
pubmed: 22566109
Yale J Biol Med. 2017 Jun 23;90(2):269-281
pubmed: 28656013
Nat Rev Drug Discov. 2015 Dec;14(12):821-32
pubmed: 26493767
Curr Opin Microbiol. 2020 Oct;57:31-40
pubmed: 32619833
Nat Mater. 2013 Nov;12(11):991-1003
pubmed: 24150417
Theranostics. 2018 Jan 1;8(3):693-709
pubmed: 29344299
Sci Rep. 2020 Aug 26;10(1):14204
pubmed: 32848171
Mol Pharm. 2007 Nov-Dec;4(6):807-18
pubmed: 17999464
Exploration (Beijing). 2022 May 23;2(5):20210145
pubmed: 37325499
Eur J Immunol. 2011 May;41(5):1203-17
pubmed: 21523780
Curr Infect Dis Rep. 2018 Jun 29;20(9):29
pubmed: 29959541
Biomater Sci. 2019 Aug 1;7(8):3277-3286
pubmed: 31180396
Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13644-9
pubmed: 26473305
Eur J Med Chem. 2018 Sep 5;157:705-715
pubmed: 30138802
Nat Commun. 2018 Jan 2;9(1):22
pubmed: 29295973
Expert Opin Drug Metab Toxicol. 2019 Sep;15(9):705-733
pubmed: 31361978
Antibiotics (Basel). 2021 Jan 28;10(2):
pubmed: 33525724
Nat Rev Microbiol. 2019 Apr;17(4):203-218
pubmed: 30737488
Am J Physiol Endocrinol Metab. 2003 Aug;285(2):E433-7
pubmed: 12857678
Chem Biol Interact. 2019 Aug 1;308:294-303
pubmed: 31158333
Clin Ther. 2020 Apr;42(4):625-633
pubmed: 32199609
Adv Mater. 2018 Oct;30(43):e1803618
pubmed: 30203430
Nat Commun. 2014 Jun 24;5:4262
pubmed: 24957696
ACS Appl Mater Interfaces. 2017 May 24;9(20):16880-16889
pubmed: 28481077