Advances in molecular characterization of pediatric acute megakaryoblastic leukemia not associated with Down syndrome; impact on therapy development.

acute megakaryoblastic leukemia (AMKL) acute myeloid leukemia chimeric fusions cytogenetics genomics non-Down syndrome AMKL therapeutic targets transcriptomics

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2023
Historique:
received: 21 02 2023
accepted: 19 05 2023
medline: 16 6 2023
pubmed: 16 6 2023
entrez: 16 6 2023
Statut: epublish

Résumé

Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML) in which leukemic blasts have megakaryocytic features. AMKL makes up 4%-15% of newly diagnosed pediatric AML, typically affecting young children (less than 2 years old). AMKL associated with Down syndrome (DS) shows

Identifiants

pubmed: 37325571
doi: 10.3389/fcell.2023.1170622
pii: 1170622
pmc: PMC10267407
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1170622

Informations de copyright

Copyright © 2023 Li and Kalev‐Zylinska.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Jixia Li (J)

Blood and Cancer Biology Laboratory, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
Department of Laboratory Medicine, School of Medicine, Foshan University, Foshan, China.

Maggie L Kalev-Zylinska (ML)

Blood and Cancer Biology Laboratory, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
Haematology Laboratory, Department of Pathology and Laboratory Medicine, Auckland City Hospital, Auckland, New Zealand.

Classifications MeSH