How to train your myeloid cells: a way forward for helminth vaccines?
cellular immunity
helminth
myeloid cells
trained immunity
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
02
2023
accepted:
25
04
2023
medline:
19
6
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
epublish
Résumé
Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no vaccine is currently available for humans, the current strategy for elimination as a public health problem relies on preventive chemotherapy. Despite more than 20 years of intense research effort, the development of human helminth vaccines (HHVs) has not yet come to fruition. Current vaccine development focuses on peptide antigens that trigger strong humoral immunity, with the goal of generating neutralizing antibodies against key parasite molecules. Notably, this approach aims to reduce the pathology of infection, not worm burden, with only partial protection observed in laboratory models. In addition to the typical translational hurdles that vaccines struggle to overcome, HHVs face several challenges (1): helminth infections have been associated with poor vaccine responses in endemic countries, probably due to the strong immunomodulation caused by these parasites, and (2) the target population displays pre-existing type 2 immune responses to helminth products, increasing the likelihood of adverse events such as allergy or anaphylaxis. We argue that such traditional vaccines are unlikely to be successful on their own and that, based on laboratory models, mucosal and cellular-based vaccines could be a way to move forward in the fight against helminth infection. Here, we review the evidence for the role of innate immune cells, specifically the myeloid compartment, in controlling helminth infections. We explore how the parasite may reprogram myeloid cells to avoid killing, notably using excretory/secretory (ES) proteins and extracellular vesicles (EVs). Finally, learning from the field of tuberculosis, we will discuss how anti-helminth innate memory could be harnessed in a mucosal-trained immunity-based vaccine.
Identifiants
pubmed: 37325618
doi: 10.3389/fimmu.2023.1163364
pmc: PMC10266106
doi:
Substances chimiques
Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1163364Informations de copyright
Copyright © 2023 Doolan, Putananickal, Tritten and Bouchery.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Vet Parasitol. 2018 Dec 15;264:52-57
pubmed: 30503092
Front Immunol. 2019 May 21;10:1109
pubmed: 31178861
Anal Chim Acta. 2018 Dec 11;1037:107-118
pubmed: 30292284
Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5169-77
pubmed: 25404305
Front Mol Biosci. 2022 Jan 10;8:807821
pubmed: 35083280
J Immunol. 2015 Jul 1;195(1):317-28
pubmed: 25987744
Cell Rep. 2020 May 19;31(7):107634
pubmed: 32433977
PLoS Negl Trop Dis. 2021 Sep 29;15(9):e0009828
pubmed: 34587193
Nat Commun. 2014 Nov 25;5:5488
pubmed: 25421927
Nat Commun. 2019 May 28;10(1):2344
pubmed: 31138806
Parasit Vectors. 2016 Jan 27;9:29
pubmed: 26813098
Front Mol Biosci. 2022 Jun 28;9:909312
pubmed: 35836928
Microorganisms. 2022 Dec 25;11(1):
pubmed: 36677353
Cell Host Microbe. 2021 Apr 14;29(4):579-593.e5
pubmed: 33857419
Sci Rep. 2020 Feb 21;10(1):3147
pubmed: 32081954
Vet Parasitol. 2017 Feb 15;235:29-36
pubmed: 28215864
PLoS Negl Trop Dis. 2017 Jan 3;11(1):e0005279
pubmed: 28045905
Int J Parasitol. 2020 Aug;50(9):623-633
pubmed: 32659278
PLoS Negl Trop Dis. 2015 Dec 08;9(12):e0004268
pubmed: 26645974
Am J Trop Med Hyg. 1984 Jan;33(1):104-15
pubmed: 6696169
Front Immunol. 2021 Feb 24;12:621311
pubmed: 33717121
Front Vet Sci. 2019 Oct 16;6:332
pubmed: 31750318
J Biol Chem. 2002 Dec 13;277(50):48122-9
pubmed: 12359728
Cell Rep. 2017 May 23;19(8):1545-1557
pubmed: 28538175
Science. 2011 Jan 7;331(6013):44-9
pubmed: 21212348
Int J Parasitol. 2016 Jan;46(1):1-5
pubmed: 26460238
Front Microbiol. 2019 Jan 14;9:3225
pubmed: 30692968
Parasitol Res. 2015 May;114(5):1865-73
pubmed: 25855345
J Biol Chem. 1994 Apr 1;269(13):10008-15
pubmed: 7908286
Cell Host Microbe. 2020 Aug 12;28(2):322-334.e5
pubmed: 32544459
Sci Immunol. 2018 Aug 24;3(26):
pubmed: 30143555
Am J Trop Med Hyg. 2003 Jul;69(1):87-91
pubmed: 12932104
Nat Commun. 2015 Apr 27;6:6970
pubmed: 25912172
Int J Parasitol. 2017 Mar;47(4):171-183
pubmed: 28012717
Cell Host Microbe. 2018 Jan 10;23(1):89-100.e5
pubmed: 29324233
Immunity. 2017 May 16;46(5):863-874.e4
pubmed: 28514691
Front Immunol. 2022 Sep 27;13:969340
pubmed: 36238293
Immunity. 2018 Nov 20;49(5):801-818
pubmed: 30462997
Nat Rev Immunol. 2013 Aug;13(8):607-14
pubmed: 23827958
Immunity. 2015 Sep 15;43(3):515-26
pubmed: 26377898
Ann Parasitol Hum Comp. 1987;62(1):47-57
pubmed: 3566090
Front Immunol. 2021 Oct 22;12:699563
pubmed: 34745089
PLoS One. 2013 Oct 21;8(10):e78357
pubmed: 24205209
Front Immunol. 2020 Nov 19;11:572326
pubmed: 33329535
Biosci Rep. 2019 Feb 15;39(2):
pubmed: 30670631
Vet Parasitol. 2020 Sep 16;287:109243
pubmed: 33010786
Front Immunol. 2020 Jul 14;11:1782
pubmed: 32760409
Front Immunol. 2018 Dec 17;9:2936
pubmed: 30619296
J Exp Med. 1979 Dec 1;150(6):1456-71
pubmed: 390086
Metabolites. 2020 Nov 06;10(11):
pubmed: 33171998
Sci Rep. 2021 Jun 16;11(1):12718
pubmed: 34135384
Nat Immunol. 2006 May;7(5):507-16
pubmed: 16617337
J Immunol. 2012 Nov 1;189(9):4371-8
pubmed: 23024277
Immunohorizons. 2018 Sep 26;2(8):296-304
pubmed: 31022700
Int Immunopharmacol. 2022 Aug;109:108907
pubmed: 35691271
Clin Exp Allergy. 2005 Jul;35(7):873-9
pubmed: 16008672
Parasitol Int. 2020 Dec;79:102178
pubmed: 32828838
Biomedicines. 2019 Oct 31;7(4):
pubmed: 31683524
ACS Infect Dis. 2021 Dec 10;7(12):3264-3276
pubmed: 34767348
Vet Parasitol. 2008 May 31;153(3-4):302-12
pubmed: 18337013
Sci Rep. 2016 Oct 18;6:35559
pubmed: 27752109
Yonago Acta Med. 2020 Jan 24;63(1):34-41
pubmed: 32158331
Front Immunol. 2018 Oct 12;9:2349
pubmed: 30369927
Vet Clin North Am Food Anim Pract. 2020 Mar;36(1):159-171
pubmed: 32029181
Parasitol Res. 2022 May;121(5):1379-1388
pubmed: 35320838
Metabolomics. 2019 Jun 28;15(7):101
pubmed: 31254203
Mol Nutr Food Res. 2021 Jan;65(1):e1901071
pubmed: 32223047
Immunity. 2004 May;20(5):623-35
pubmed: 15142530
Cell Rep. 2022 Nov 22;41(8):111674
pubmed: 36417867
Scand J Immunol. 2010 Dec;72(6):491-503
pubmed: 21044123
Expert Rev Vaccines. 2016 May;15(5):619-27
pubmed: 26651503
Front Microbiol. 2017 Sep 21;8:1834
pubmed: 28983296
Exp Parasitol. 1996 Apr;82(3):267-78
pubmed: 8631378
PLoS Pathog. 2018 Feb 9;14(2):e1006870
pubmed: 29425229
Int J Parasitol. 2020 Aug;50(9):635-645
pubmed: 32652128
J Biol Chem. 2009 Dec 4;284(49):34211-22
pubmed: 19801663
Mucosal Immunol. 2020 Nov;13(6):958-968
pubmed: 32636457
Science. 2014 Sep 26;345(6204):1251086
pubmed: 25258085
J Infect Dis. 2010 Nov 1;202(9):1369-79
pubmed: 20863227
Sci Rep. 2018 Mar 14;8(1):4497
pubmed: 29540770
Mol Ther. 2022 May 4;30(5):2092-2107
pubmed: 35351657
Semin Immunol. 2021 Mar;53:101531
pubmed: 34836773
PLoS Pathog. 2019 Jun 4;15(6):e1007817
pubmed: 31163079
Mol Biochem Parasitol. 2014 Mar-Apr;194(1-2):1-8
pubmed: 24671112
Cell Rep. 2022 Jan 11;38(2):110215
pubmed: 35021079
Parasit Vectors. 2015 Sep 17;8:459
pubmed: 26382743
Dev Comp Immunol. 2021 Jan;114:103787
pubmed: 32791176
Clin Exp Allergy. 2023 Feb;53(2):145-155
pubmed: 36494877
Semin Immunopathol. 2021 Jun;43(3):307-317
pubmed: 33772336
Science. 2017 Jun 9;356(6342):1076-1080
pubmed: 28495878
Nat Commun. 2021 Mar 25;12(1):1864
pubmed: 33767144
Int Immunol. 2021 Nov 25;33(12):737-742
pubmed: 34611710
Curr Res Parasitol Vector Borne Dis. 2021 Feb 24;1:100018
pubmed: 35284853
Virulence. 2012 Nov 15;3(7):668-77
pubmed: 23221477
Parasitology. 2019 Dec;146(14):1725-1732
pubmed: 31405388
Trends Parasitol. 2017 Mar;33(3):194-201
pubmed: 27865740
Parasit Vectors. 2016 Jan 04;9:5
pubmed: 26727915
Front Immunol. 2021 Apr 22;12:671966
pubmed: 33968080
Science. 2011 Jun 10;332(6035):1284-8
pubmed: 21566158
J Biol Chem. 2010 Jan 29;285(5):3383-92
pubmed: 19923225
Eur J Immunol. 2017 Feb;47(2):257-268
pubmed: 27891580
Nature. 2014 Jun 5;510(7503):157-61
pubmed: 24759321
Infect Immun. 2019 Mar 25;87(4):
pubmed: 30670556
J Clin Invest. 2020 Oct 1;130(10):5591-5602
pubmed: 32692728
Parasite Immunol. 2007 Mar;29(3):127-37
pubmed: 17266740
Vet Parasitol. 2021 Apr;292:109386
pubmed: 33652209
PLoS Negl Trop Dis. 2018 Nov 29;12(11):e0006992
pubmed: 30496188
Parasitology. 2020 Jul;147(8):897-906
pubmed: 32138794
Front Immunol. 2020 Sep 25;11:2015
pubmed: 33072069
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Feb;1862(2):246-254
pubmed: 27871882
Sci Rep. 2016 Jul 11;6:29496
pubmed: 27403891
Sci Rep. 2019 Apr 25;9(1):6547
pubmed: 31024043
Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228
pubmed: 29339798
Immunity. 2020 May 19;52(5):753-766
pubmed: 32433948
PLoS Negl Trop Dis. 2019 Jan 18;13(1):e0007087
pubmed: 30657764
Parasit Vectors. 2016 Jan 04;9:6
pubmed: 26728323
Mol Biochem Parasitol. 2005 Feb;139(2):197-203
pubmed: 15664654
J Leukoc Biol. 2013 Aug;94(2):353-65
pubmed: 23709687
Nat Rev Immunol. 2023 Apr;23(4):236-250
pubmed: 35927511
Parasit Vectors. 2017 Feb 17;10(1):89
pubmed: 28212670
Immunology. 2013 Apr;138(4):370-81
pubmed: 23240853
Mucosal Immunol. 2017 Mar;10(2):481-492
pubmed: 27381924
EMBO Rep. 2020 Jan 7;21(1):e47882
pubmed: 31825165
Blood. 2006 Oct 1;108(7):2420-7
pubmed: 16772607
Sci Transl Med. 2020 Apr 22;12(540):
pubmed: 32321863
J Biol Chem. 2002 Aug 23;277(34):31207-13
pubmed: 12050167
Parasite Immunol. 2022 Jun;44(6):e12911
pubmed: 35124825
Parasite Immunol. 1981 Winter;3(4):359-73
pubmed: 7322615
Infect Immun. 2013 Jan;81(1):133-42
pubmed: 23090958
J Allergy Clin Immunol. 2021 Sep;148(3):843-857.e6
pubmed: 33684437
Int J Parasitol. 2007 Oct;37(12):1367-78
pubmed: 17555758
Science. 2014 Sep 26;345(6204):1250684
pubmed: 25258083
PLoS Negl Trop Dis. 2019 Nov 26;13(11):e0007811
pubmed: 31770367
Int J Mol Sci. 2022 Mar 30;23(7):
pubmed: 35409152
Mol Biochem Parasitol. 2009 Mar;164(1):26-31
pubmed: 19041905
Parasitology. 2000;120 Suppl:S17-23
pubmed: 10874707
Parasite Immunol. 2018 Sep;40(9):e12572
pubmed: 29992577
Infect Immun. 2005 Jan;73(1):395-402
pubmed: 15618177
Exp Parasitol. 2022 Aug;239:108283
pubmed: 35636497
Nat Med. 2012 Jan 15;18(2):260-6
pubmed: 22245779
Front Immunol. 2018 May 08;9:968
pubmed: 29867950
Semin Immunol. 2021 Mar;53:101529
pubmed: 34815162
Sci Rep. 2018 Dec 4;8(1):17598
pubmed: 30514873
Nat Rev Mol Cell Biol. 2022 May;23(5):369-382
pubmed: 35260831
J Immunol. 2021 Apr 1;206(7):1618-1630
pubmed: 33579723
PLoS Negl Trop Dis. 2021 Oct 1;15(10):e0009732
pubmed: 34597297
Front Immunol. 2018 Jan 24;9:11
pubmed: 29416536
Immunobiology. 2018 Dec;223(12):834-838
pubmed: 30197196
PLoS Negl Trop Dis. 2018 Apr 16;12(4):e0006438
pubmed: 29659599
JCI Insight. 2020 Jul 23;5(14):
pubmed: 32573494
Cell Rep. 2021 Jan 12;34(2):108621
pubmed: 33440150
PLoS Negl Trop Dis. 2015 Sep 24;9(9):e0004069
pubmed: 26401956
Front Immunol. 2022 Apr 08;13:868343
pubmed: 35464438
J Exp Med. 2013 Nov 18;210(12):2583-95
pubmed: 24166714
Front Allergy. 2021 Jun 14;2:695262
pubmed: 35387058
Nat Immunol. 2022 Dec;23(12):1687-1702
pubmed: 36456739
Front Immunol. 2022 Sep 21;13:974332
pubmed: 36211336
Nat Med. 2007 Nov;13(11):1375-81
pubmed: 17952092
Acta Trop. 2021 Jan;213:105761
pubmed: 33221281
Science. 2017 Jun 9;356(6342):1072-1076
pubmed: 28495875
PLoS Pathog. 2015 Mar 27;11(3):e1004676
pubmed: 25816012
Nat Immunol. 2014 Oct;15(10):938-46
pubmed: 25173346
J Immunol. 2001 Sep 15;167(6):3207-15
pubmed: 11544307
Sci Transl Med. 2016 Oct 26;8(362):362ra143
pubmed: 27797959
Front Immunol. 2022 Aug 25;13:979491
pubmed: 36091065
J Clin Invest. 2022 Jun 1;132(11):
pubmed: 35642634
J Immunol. 2018 Feb 15;200(4):1243-1248
pubmed: 29330325
J Allergy Clin Immunol. 2012 Jul;130(1):169-76.e6
pubmed: 22633322
FASEB J. 2017 Feb;31(2):719-731
pubmed: 27806992
Semin Immunol. 2021 Mar;53:101532
pubmed: 34823996
FEMS Immunol Med Microbiol. 2005 Feb 1;43(2):115-24
pubmed: 15681140
Vaccine. 2013 Apr 18;31 Suppl 2:B227-32
pubmed: 23598487
Expert Rev Vaccines. 2021 Nov;20(11):1389-1393
pubmed: 34720028
J Immunol. 1990 Apr 15;144(8):3166-73
pubmed: 2324497
Cell Host Microbe. 2020 Feb 12;27(2):277-289.e6
pubmed: 32053791
J Immunol. 2014 Sep 15;193(6):2709-17
pubmed: 25108019
Nat Commun. 2017 Nov 23;8(1):1741
pubmed: 29170498
Parasit Vectors. 2015 Nov 26;8:607
pubmed: 26610335
Parasite Immunol. 1989 May;11(3):293-7
pubmed: 2671869
J Leukoc Biol. 2009 May;85(5):844-54
pubmed: 19179453
Front Immunol. 2019 May 07;10:1010
pubmed: 31134080
J Immunol. 2016 Oct 1;197(7):2948-57
pubmed: 27559049
J Helminthol. 2015 May;89(3):367-74
pubmed: 24703095
Infect Drug Resist. 2021 Dec 15;14:5403-5410
pubmed: 34938088
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17537-42
pubmed: 22988082
PLoS Negl Trop Dis. 2020 Apr 1;14(4):e0008192
pubmed: 32236093
PLoS Pathog. 2011 Jan 06;7(1):e1001248
pubmed: 21253577
Mucosal Immunol. 2019 Mar;12(2):352-362
pubmed: 30401814
Nat Immunol. 2019 May;20(5):571-580
pubmed: 30936493
EMBO Rep. 2022 May 4;23(5):e54096
pubmed: 35357743
Immunology. 1973 Mar;24(3):531-43
pubmed: 4705618
Sci Rep. 2021 Mar 24;11(1):6712
pubmed: 33762636
Nature. 2009 Jan 29;457(7229):557-61
pubmed: 19136945
NPJ Vaccines. 2021 Jan 26;6(1):17
pubmed: 33500417
Immunobiology. 2015 Jul;220(7):934-9
pubmed: 25758714
Microbes Infect. 2014 Jun;16(6):502-11
pubmed: 24642003
Cell Immunol. 2022 Dec;382:104630
pubmed: 36270066
Parasit Vectors. 2015 Aug 04;8:408
pubmed: 26238343
Mucosal Immunol. 2016 Nov;9(6):1366-1371
pubmed: 27554296
Front Microbiol. 2022 Nov 10;13:1050271
pubmed: 36439842
Immunol Cell Biol. 2021 Sep;99(8):848-864
pubmed: 33988885
Exp Parasitol. 2008 Apr;118(4):569-75
pubmed: 18199436
Int J Parasitol. 2016 Mar;46(3):147-156
pubmed: 26812025
Front Immunol. 2021 Aug 12;12:715766
pubmed: 34475874
Front Immunol. 2018 Apr 30;9:850
pubmed: 29760697
Front Immunol. 2018 Sep 19;9:2132
pubmed: 30283458
J Exp Med. 2014 Jun 30;211(7):1281-8
pubmed: 24889202
PLoS Pathog. 2016 Feb 22;12(2):e1005461
pubmed: 26900854
Vaccines (Basel). 2020 Sep 22;8(3):
pubmed: 32971770
Cytokine. 2022 Aug;156:155919
pubmed: 35649322
Eur J Immunol. 2004 Nov;34(11):3047-59
pubmed: 15468056
Pathogens. 2021 Jul 22;10(8):
pubmed: 34451389
PLoS Pathog. 2018 Mar 22;14(3):e1006931
pubmed: 29566094
Front Immunol. 2022 Oct 24;13:866373
pubmed: 36353644
Parasite. 2022;29:16
pubmed: 35315767
Immunity. 2022 Jul 12;55(7):1250-1267.e12
pubmed: 35709757
PLoS Negl Trop Dis. 2021 Jan 7;15(1):e0008884
pubmed: 33411714
Immunol Cell Biol. 2022 Apr;100(4):223-234
pubmed: 35156238
Cell Rep. 2020 Apr 21;31(3):107548
pubmed: 32320649
PLoS Biol. 2010 Oct 19;8(10):e1000525
pubmed: 20976099
PLoS Biol. 2018 Apr 18;16(4):e2005504
pubmed: 29668708
Parasit Vectors. 2019 May 20;12(1):248
pubmed: 31109364
Parasit Vectors. 2022 Dec 20;15(1):475
pubmed: 36539832
PLoS Pathog. 2014 Mar 13;10(3):e1003988
pubmed: 24626328
Nat Rev Genet. 2015 Jul;16(7):421-33
pubmed: 26077373
Int J Biol Macromol. 2021 Dec 15;193(Pt B):1379-1390
pubmed: 34774593
PLoS Pathog. 2013;9(11):e1003771
pubmed: 24244174
Acta Trop. 2022 Oct;234:106615
pubmed: 35901919
Front Immunol. 2019 Jan 25;9:3161
pubmed: 30740113