Increased Ca

Animals Humans Mice Arrhythmias, Cardiac / metabolism Calcium / metabolism Calcium Signaling / physiology Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism Heart Defects, Congenital / metabolism Myocytes, Cardiac / metabolism Ryanodine Receptor Calcium Release Channel / genetics Sarcoplasmic Reticulum / metabolism
cardiomyopathies sarcoplasmic reticulum tachycardia, ventricular

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
07 07 2023
Historique:
medline: 10 7 2023
pubmed: 16 6 2023
entrez: 16 6 2023
Statut: ppublish

Résumé

A loss-of-function cardiac ryanodine receptor (RyR2) mutation, I4855M We generated a mouse model expressing the CRDS-LVNC-associated RyR2-I4855M As in humans, RyR2-I4855M The RyR2-I4855M

Sections du résumé

BACKGROUND
A loss-of-function cardiac ryanodine receptor (RyR2) mutation, I4855M
METHODS
We generated a mouse model expressing the CRDS-LVNC-associated RyR2-I4855M
RESULTS
As in humans, RyR2-I4855M
CONCLUSIONS
The RyR2-I4855M

Identifiants

DOI: 10.1161/CIRCRESAHA.123.322504 PMID: 37325910
pubmed: 37325910
doi: 10.1161/CIRCRESAHA.123.322504
doi:

Substances chimiques

Calcium SY7Q814VUP
Calcium-Calmodulin-Dependent Protein Kinase Type 2 EC 2.7.11.17
Ryanodine Receptor Calcium Release Channel 0
ryanodine receptor 2. mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

177-192

Subventions

Organisme : CIHR
ID : PJT-155940
Pays : Canada

Commentaires et corrections

Type : CommentIn

Auteurs

Mingke Ni (M)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).

Yanhui Li (Y)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).
ORCID: 0000-0002-5543-8363

Jinhong Wei (J)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).
School of Medicine, Northwest University, Xi 'an, China (J.W.).
ORCID: 0000-0002-5251-9192

Zhenpeng Song (Z)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).

Hui Wang (H)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).

Jinjing Yao (J)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).

Yong-Xiang Chen (YX)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).

Darrell Belke (D)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).

John Paul Estillore (JP)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).

Ruiwu Wang (R)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).

Alexander Vallmitjana (A)

Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona, Spain (A.V., R.B.).
ORCID: 0000-0002-7149-9385

Raul Benitez (R)

Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona, Spain (A.V., R.B.).
Institut de Recerca Sant Joan de Déu (IRSJD), Barcelona, Spain (R.B.).
ORCID: 0000-0002-8782-9406

Leif Hove-Madsen (L)

Biomedical Research Institute Barcelona IIBB-CSIC, IIB Sant Pau and CIBERCV, Hospital de Sant Pau, Barcelona, Spain (L.H.-M.).
ORCID: 0000-0001-5493-3998

Wei Feng (W)

Department of Medicine, School of Medicine, University of California, San Diego, La Jolla (W.F., J.C.).

Ju Chen (J)

Department of Medicine, School of Medicine, University of California, San Diego, La Jolla (W.F., J.C.).
ORCID: 0000-0001-7674-4776

Thomas M Roston (TM)

Division of Pediatric Cardiology, Department of Pediatrics (T.M.R., S.S.), University of British Columbia, Vancouver, Canada.
ORCID: 0000-0001-5663-4377

Shubhayan Sanatani (S)

Division of Pediatric Cardiology, Department of Pediatrics (T.M.R., S.S.), University of British Columbia, Vancouver, Canada.
ORCID: 0000-0001-9296-7400

Anna Lehman (A)

Department of Medical Genetics (A.L.), University of British Columbia, Vancouver, Canada.

S R Wayne Chen (SRW)

Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (M.N., Y.L., J.W., Z.S., H.W., J.Y., Y.-X.C., D.B., J.P.E., R.W., S.R.W.C.).
ORCID: 0000-0001-5808-0304

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Increased Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Increased Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Increased Ca
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Increased Ca
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Increased Ca
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Increased Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Calcium-Calmodulin-Dependent Protein Kinase Type 2 › Increased Ca
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations cardiovasculaires › Cardiopathies congénitales › Increased Ca
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Increased Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canal de libération du calcium du récepteur à la ryanodine › Increased Ca
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Réticulum endoplasmique lisse › Réticulum sarcoplasmique › Increased Ca