Phosphorus and Silicon-Based Macromolecules as Degradable Biomedical Polymers.
degradable polymers
inorganic polymers
polyphosphazenes
polyphosphoesters
polyphosphoramidates
polysilylethers
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
revised:
17
05
2023
received:
24
03
2023
medline:
7
11
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
ppublish
Résumé
Synthetic polymers are indispensable in biomedical applications because they can be fabricated with consistent and reproducible properties, facile scalability, and customizable functionality to perform diverse tasks. However, currently available synthetic polymers have limitations, most notably when timely biodegradation is required. Despite there being, in principle, an entire periodic table to choose from, with the obvious exception of silicones, nearly all known synthetic polymers are combinations of carbon, nitrogen, and oxygen in the main chain. Expanding this to main-group heteroatoms can open the way to novel material properties. Herein the authors report on research to incorporate the chemically versatile and abundant silicon and phosphorus into polymers to induce cleavability into the polymer main chain. Less stable polymers, which degrade in a timely manner in mild biological environments, have considerable potential in biomedical applications. Herein the basic chemistry behind these materials is described and some recent studies into their medical applications are highlighted.
Identifiants
pubmed: 37326117
doi: 10.1002/mabi.202300127
doi:
Substances chimiques
Polymers
0
Phosphorus
27YLU75U4W
Silicon
Z4152N8IUI
Macromolecular Substances
0
Silicones
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300127Informations de copyright
© 2023 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.
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