Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures.
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
received:
19
12
2022
accepted:
02
03
2023
medline:
21
8
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
ppublish
Résumé
Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because the pathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Pain biomarkers could potentially identify and measure biological pathways and phenotypical expressions that are altered by pain, provide insight into biological treatment targets, and help identify at-risk patients who might benefit from early intervention. Biomarkers are used to diagnose, track, and treat other diseases, but no validated clinical biomarkers exist yet for chronic pain. To address this problem, the National Institutes of Health Common Fund launched the Acute to Chronic Pain Signatures (A2CPS) program to evaluate candidate biomarkers, develop them into biosignatures, and discover novel biomarkers for chronification of pain after surgery. This article discusses candidate biomarkers identified by A2CPS for evaluation, including genomic, proteomic, metabolomic, lipidomic, neuroimaging, psychophysical, psychological, and behavioral measures. Acute to Chronic Pain Signatures will provide the most comprehensive investigation of biomarkers for the transition to chronic postsurgical pain undertaken to date. Data and analytic resources generatedby A2CPS will be shared with the scientific community in hopes that other investigators will extract valuable insights beyond A2CPS's initial findings. This article will review the identified biomarkers and rationale for including them, the current state of the science on biomarkers of the transition from acute to chronic pain, gaps in the literature, and how A2CPS will address these gaps.
Identifiants
pubmed: 37326643
doi: 10.1097/j.pain.0000000000002938
pii: 00006396-990000000-00332
pmc: PMC10436361
mid: NIHMS1895961
doi:
Substances chimiques
Biomarkers
0
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1912-1926Subventions
Organisme : NIDA NIH HHS
ID : U54 DA049113
Pays : United States
Organisme : NINDS NIH HHS
ID : UM1 NS118922
Pays : United States
Organisme : NIDA NIH HHS
ID : U54 DA049115
Pays : United States
Organisme : NIDA NIH HHS
ID : U54 DA049116
Pays : United States
Organisme : NINDS NIH HHS
ID : UM1 NS112874
Pays : United States
Organisme : NIDA NIH HHS
ID : U54 DA049110
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS112873
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS077179
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS077352
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.
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