Evolutionary analysis of JC polyomavirus in Misiones' population yields insight into the population dynamics of the early human dispersal in the Americas.
Amerindian
Ancestry
Migration
Phylogeny
Virus
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
14
03
2023
revised:
23
05
2023
accepted:
25
05
2023
medline:
24
7
2023
pubmed:
17
6
2023
entrez:
16
6
2023
Statut:
ppublish
Résumé
JC polyomavirus (JCV) has an ethno-geographical distribution across human populations. Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker. Viral detection and characterization was conducted by PCR amplification and evolutionary analysis of the intergenic region sequences. 22 out of 121 samples were positive for JCV, including 5 viral lineages: MY (n = 8), Eu-a (n = 7), B1-c (n = 4), B1-b (n = 2) and Af2 (n = 1). MY sequences clustered within a branch of Native American origin that diverged from its Asian counterpart about 21,914 years ago (HPD 95% interval 15,383-30,177), followed by a sustained demographic expansion around 5000 years ago. JCV in Misiones reflects the multiethnic origin of the current population, with an important Amerindian contribution. Analysis of the MY viral lineage shows a pattern consistent with the arrival of early human migrations to the Americas and a population expansion by the pre-Columbian native societies.
Sections du résumé
BACKGROUND
JC polyomavirus (JCV) has an ethno-geographical distribution across human populations.
OBJECTIVE
Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker.
METHODS
Viral detection and characterization was conducted by PCR amplification and evolutionary analysis of the intergenic region sequences.
RESULTS
22 out of 121 samples were positive for JCV, including 5 viral lineages: MY (n = 8), Eu-a (n = 7), B1-c (n = 4), B1-b (n = 2) and Af2 (n = 1). MY sequences clustered within a branch of Native American origin that diverged from its Asian counterpart about 21,914 years ago (HPD 95% interval 15,383-30,177), followed by a sustained demographic expansion around 5000 years ago.
CONCLUSIONS
JCV in Misiones reflects the multiethnic origin of the current population, with an important Amerindian contribution. Analysis of the MY viral lineage shows a pattern consistent with the arrival of early human migrations to the Americas and a population expansion by the pre-Columbian native societies.
Identifiants
pubmed: 37327595
pii: S0042-6822(23)00114-9
doi: 10.1016/j.virol.2023.05.009
pii:
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100-108Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.