Neurotoxic properties of the Zika virus envelope protein.
Envelope protein
Neurological complications
Neurotoxicity
Poly adenosine diphosphate -ribose polymerase 1
Zika virus
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
28
02
2023
revised:
31
05
2023
accepted:
11
06
2023
pmc-release:
01
09
2024
medline:
24
7
2023
pubmed:
17
6
2023
entrez:
16
6
2023
Statut:
ppublish
Résumé
Prenatal Zika virus (ZIKV) infection is a serious global concern as it can lead to brain injury and many serious birth defects, collectively known as congenital Zika syndrome. Brain injury likely results from viral mediated toxicity in neural progenitor cells. Additionally, postnatal ZIKV infections have been linked to neurological complications, yet the mechanisms driving these manifestations are not well understood. Existing data suggest that the ZIKV envelope protein can persist in the central nervous system for extended periods of time, but it is unknown if this protein can independently contribute to neuronal toxicity. Here we find that the ZIKV envelope protein is neurotoxic, leading to overexpression of poly adenosine diphosphate -ribose polymerase 1, which can induce parthanatos. Together, these data suggest that neuronal toxicity resulting from the envelope protein may contribute to the pathogenesis of post-natal ZIKV-related neurologic complications.
Identifiants
pubmed: 37327963
pii: S0014-4886(23)00154-1
doi: 10.1016/j.expneurol.2023.114469
pmc: PMC10527427
mid: NIHMS1911681
pii:
doi:
Substances chimiques
Viral Envelope Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
114469Subventions
Organisme : Intramural NIH HHS
ID : ZIA NS003130
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no competing financial interests or other competing interests.
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