Fitness, growth and transmissibility of SARS-CoV-2 genetic variants.
Journal
Nature reviews. Genetics
ISSN: 1471-0064
Titre abrégé: Nat Rev Genet
Pays: England
ID NLM: 100962779
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
accepted:
25
04
2023
medline:
18
9
2023
pubmed:
17
6
2023
entrez:
16
6
2023
Statut:
ppublish
Résumé
The massive scale of the global SARS-CoV-2 sequencing effort created new opportunities and challenges for understanding SARS-CoV-2 evolution. Rapid detection and assessment of new variants has become one of the principal objectives of genomic surveillance of SARS-CoV-2. Because of the pace and scale of sequencing, new strategies have been developed for characterizing fitness and transmissibility of emerging variants. In this Review, I discuss a wide range of approaches that have been rapidly developed in response to the public health threat posed by emerging variants, ranging from new applications of classic population genetics models to contemporary synthesis of epidemiological models and phylodynamic analysis. Many of these approaches can be adapted to other pathogens and will have increasing relevance as large-scale pathogen sequencing becomes a regular feature of many public health systems.
Identifiants
pubmed: 37328556
doi: 10.1038/s41576-023-00610-z
pii: 10.1038/s41576-023-00610-z
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
724-734Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2023. Springer Nature Limited.
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