Fitness, growth and transmissibility of SARS-CoV-2 genetic variants.


Journal

Nature reviews. Genetics
ISSN: 1471-0064
Titre abrégé: Nat Rev Genet
Pays: England
ID NLM: 100962779

Informations de publication

Date de publication:
10 2023
Historique:
accepted: 25 04 2023
medline: 18 9 2023
pubmed: 17 6 2023
entrez: 16 6 2023
Statut: ppublish

Résumé

The massive scale of the global SARS-CoV-2 sequencing effort created new opportunities and challenges for understanding SARS-CoV-2 evolution. Rapid detection and assessment of new variants has become one of the principal objectives of genomic surveillance of SARS-CoV-2. Because of the pace and scale of sequencing, new strategies have been developed for characterizing fitness and transmissibility of emerging variants. In this Review, I discuss a wide range of approaches that have been rapidly developed in response to the public health threat posed by emerging variants, ranging from new applications of classic population genetics models to contemporary synthesis of epidemiological models and phylodynamic analysis. Many of these approaches can be adapted to other pathogens and will have increasing relevance as large-scale pathogen sequencing becomes a regular feature of many public health systems.

Identifiants

pubmed: 37328556
doi: 10.1038/s41576-023-00610-z
pii: 10.1038/s41576-023-00610-z
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

724-734

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Erik Volz (E)

Department of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK. e.volz@imperial.ac.uk.

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