Two-Compartment Perfusion MR IVIM Model to Investigate Normal and Pathological Placental Tissue.
IVIM
microvessels/villi
placenta
trophoblast
two-perfusion model
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
17 Jun 2023
17 Jun 2023
Historique:
revised:
26
05
2023
received:
15
03
2023
accepted:
30
05
2023
medline:
17
6
2023
pubmed:
17
6
2023
entrez:
17
6
2023
Statut:
aheadofprint
Résumé
Perfusion and diffusion coexist in the placenta and can be altered by pathologies. The two-perfusion model, where f Investigate the potential of the two-perfusion IVIM model in differentiating between normal and abnormal placentas. Retrospective, case-control. 43 normal pregnancy, 9 fetal-growth-restriction (FGR), 6 small-for-gestational-age (SGA), 4 accreta, 1 increta and 2 percreta placentas. Diffusion-weighted-echo planar imaging sequence at 1.5 T. Voxel-wise signal-correction and fitting-controls were used to avoid overfitting obtaining that two-perfusion model fitted the observed data better than the IVIM model (Akaike weight: 0.94). The two-perfusion parametric-maps were quantified from ROIs in the fetal and maternal placenta and in the accretion zone of accreta placentas. The diffusion coefficient D was evaluated using a b ≥ 200 sec/mm ANOVA with Dunn-Sidák's post-hoc correction and Cohen's d test were used to compare parameters between groups. Spearman's coefficient was evaluated to study the correlation between variables. A P-value<0.05 indicated a statistically significant difference. There was a significant difference in f The two-perfusion model provides complementary information to IVIM parameters that may be useful in identifying placenta impairment. 2 TECHNICAL EFFICACY STAGE: 1.
Sections du résumé
BACKGROUND
BACKGROUND
Perfusion and diffusion coexist in the placenta and can be altered by pathologies. The two-perfusion model, where f
PURPOSE
OBJECTIVE
Investigate the potential of the two-perfusion IVIM model in differentiating between normal and abnormal placentas.
STUDY-TYPE
UNASSIGNED
Retrospective, case-control.
POPULATION
METHODS
43 normal pregnancy, 9 fetal-growth-restriction (FGR), 6 small-for-gestational-age (SGA), 4 accreta, 1 increta and 2 percreta placentas.
FIELD STRENGTH/SEQUENCE
UNASSIGNED
Diffusion-weighted-echo planar imaging sequence at 1.5 T.
ASSESSMENT
RESULTS
Voxel-wise signal-correction and fitting-controls were used to avoid overfitting obtaining that two-perfusion model fitted the observed data better than the IVIM model (Akaike weight: 0.94). The two-perfusion parametric-maps were quantified from ROIs in the fetal and maternal placenta and in the accretion zone of accreta placentas. The diffusion coefficient D was evaluated using a b ≥ 200 sec/mm
STATISTICAL-TESTS
UNASSIGNED
ANOVA with Dunn-Sidák's post-hoc correction and Cohen's d test were used to compare parameters between groups. Spearman's coefficient was evaluated to study the correlation between variables. A P-value<0.05 indicated a statistically significant difference.
RESULTS
RESULTS
There was a significant difference in f
CONCLUSION
CONCLUSIONS
The two-perfusion model provides complementary information to IVIM parameters that may be useful in identifying placenta impairment.
LEVEL OF EVIDENCE
METHODS
2 TECHNICAL EFFICACY STAGE: 1.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
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