Construction of stable microbial consortia for effective biochemical synthesis.
crossfeeding
interaction mechanisms
microbial consortia
quorum sensing
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
16
03
2023
revised:
25
04
2023
accepted:
19
05
2023
pubmed:
18
6
2023
medline:
18
6
2023
entrez:
17
6
2023
Statut:
ppublish
Résumé
Microbial consortia can complete otherwise arduous tasks through the cooperation of multiple microbial species. This concept has been applied to produce commodity chemicals, natural products, and biofuels. However, metabolite incompatibility and growth competition can make the microbial composition unstable, and fluctuating microbial populations reduce the efficiency of chemical production. Thus, controlling the populations and regulating the complex interactions between different strains are challenges in constructing stable microbial consortia. This Review discusses advances in synthetic biology and metabolic engineering to control social interactions within microbial cocultures, including substrate separation, byproduct elimination, crossfeeding, and quorum-sensing circuit design. Additionally, this Review addresses interdisciplinary strategies to improve the stability of microbial consortia and provides design principles for microbial consortia to enhance chemical production.
Identifiants
pubmed: 37330325
pii: S0167-7799(23)00155-5
doi: 10.1016/j.tibtech.2023.05.008
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1430-1441Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interest No potential conflict of interest was reported by the authors.