Role of Surgery in Metastatic Renal Cell Carcinoma.

Humans Carcinoma, Renal Cell / surgery Kidney Neoplasms / surgery Nephrectomy Cytoreduction Surgical Procedures
Cytoreductive nephrectomy Metastasectomy Renal cell carcinoma

Journal

Hematology/oncology clinics of North America
ISSN: 1558-1977
Titre abrégé: Hematol Oncol Clin North Am
Pays: United States
ID NLM: 8709473

Informations de publication

Date de publication:
10 2023
Historique:
medline: 18 9 2023
pubmed: 18 6 2023
entrez: 17 6 2023
Statut: ppublish

Résumé

Surgery has historically been the mainstay of treatment for metastatic renal cell carcinoma (mRCC), but recent clinical trials demonstrated that contemporary systemic therapies alone are non-inferior to cytoreductive nephrectomy (CN). Thus, the current role of surgery is not precisely defined. CN remains an appropriate upfront treatment for the palliation of severe symptoms, select cases of metastatic non-clear cell renal cell carcinoma, for consolidation following systemic therapy, and in the setting of oligometastatic disease. Metastasectomy is ideally utilized to achieve a disease-free state when there is minimal morbidity associated with surgery. Given the heterogenous nature of mRCC, the decision for systemic therapy and surgery should be made through a multidisciplinary approach tailored to each individual patient.

Identifiants

DOI: 10.1016/j.hoc.2023.05.004 PMID: 37330346
pubmed: 37330346
pii: S0889-8588(23)00059-X
doi: 10.1016/j.hoc.2023.05.004
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

893-905

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

José Ignacio Nolazco (JI)

Division of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, 45 Francis Street, Boston, MA 02115, USA; Servicio de Urología, Hospital Universitario Austral, Universidad Austral, Pilar, Argentina.

Steven Lee Chang (SL)

Division of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, 45 Francis Street, Boston, MA 02115, USA. Electronic address: SLCHANG@bwh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Role of Surgery in Metastatic Renal Cell Carcinoma.
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs du rein › Néphrocarcinome › Role of Surgery in Metastatic Renal Cell Carcinoma.
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs du rein › Role of Surgery in Metastatic Renal Cell Carcinoma.
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Néphrectomie › Role of Surgery in Metastatic Renal Cell Carcinoma.
questionsmedicales.fr › Procédures de chirurgie opératoire › Interventions chirurgicales de cytoréduction › Role of Surgery in Metastatic Renal Cell Carcinoma.