Intrahepatic cholestasis of pregnancy after ovarian hyperstimulation syndrome with wild-type ABCB4 gene: a peculiar case and literature review.
First trimester
Genetic polymorphisms
In vitro fertilization
Intrahepatic cholestasis of pregnancy
Ovarian hyperstimulation syndrome
Journal
BMC women's health
ISSN: 1472-6874
Titre abrégé: BMC Womens Health
Pays: England
ID NLM: 101088690
Informations de publication
Date de publication:
17 Jun 2023
17 Jun 2023
Historique:
received:
09
08
2022
accepted:
12
06
2023
medline:
19
6
2023
pubmed:
18
6
2023
entrez:
17
6
2023
Statut:
epublish
Résumé
Intrahepatic cholestasis of pregnancy (ICP) in the first trimester occurring after ovarian hyperstimulation syndrome (OHSS) is a rare condition and few cases are reported in the literature. Hyperestrogenism may explain this problem in genetically predisposed women. The objective of this article is to report one of these rare cases and offer an overview of the other published cases. We report a case of severe OHSS followed by ICP in the first trimester. The patient was admitted to the intensive care unit and was treated according to the guidelines for the management of OHSS. Moreover, the patient also received ursodeoxycholic acid for ICP, which brought to an improvement of her clinical conditions. The pregnancy continued without other complications until the 36 ICP in the first trimester might be induced by elevated serum estrogen levels after OHSS in genetically predisposed women. In these women, it might be useful to check for genetic polymorphisms to know if they have a predisposition for ICP recurrence in the third trimester of pregnancy.
Sections du résumé
BACKGROUND
BACKGROUND
Intrahepatic cholestasis of pregnancy (ICP) in the first trimester occurring after ovarian hyperstimulation syndrome (OHSS) is a rare condition and few cases are reported in the literature. Hyperestrogenism may explain this problem in genetically predisposed women. The objective of this article is to report one of these rare cases and offer an overview of the other published cases.
CASE PRESENTATION
METHODS
We report a case of severe OHSS followed by ICP in the first trimester. The patient was admitted to the intensive care unit and was treated according to the guidelines for the management of OHSS. Moreover, the patient also received ursodeoxycholic acid for ICP, which brought to an improvement of her clinical conditions. The pregnancy continued without other complications until the 36
CONCLUSIONS
CONCLUSIONS
ICP in the first trimester might be induced by elevated serum estrogen levels after OHSS in genetically predisposed women. In these women, it might be useful to check for genetic polymorphisms to know if they have a predisposition for ICP recurrence in the third trimester of pregnancy.
Identifiants
pubmed: 37330509
doi: 10.1186/s12905-023-02471-4
pii: 10.1186/s12905-023-02471-4
pmc: PMC10276903
doi:
Types de publication
Review
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
316Informations de copyright
© 2023. The Author(s).
Références
Climacteric. 2021 Dec;24(6):560-571
pubmed: 33759670
Arch Gynecol Obstet. 2020 Mar;301(3):655-664
pubmed: 32034507
J Med Case Rep. 2013 Sep 10;7:223
pubmed: 24228906
Clin Exp Reprod Med. 2013 Mar;40(1):38-41
pubmed: 23614115
J Reprod Med. 2001 Aug;46(8):765-8
pubmed: 11547654
Gastroenterology. 1976 Aug;71(2):202-7
pubmed: 939378
Am J Physiol. 1996 Dec;271(6 Pt 1):G1043-52
pubmed: 8997249
J Clin Invest. 1991 Jan;87(1):237-46
pubmed: 1845870
J Perinatol. 2014 Sep;34(9):711-2
pubmed: 25179380
Obstet Gynecol. 2014 Jul;124(1):120-133
pubmed: 24901263
Int J Fertil Steril. 2017 Apr-Jun;11(1):15-19
pubmed: 28367300
Fertil Steril. 2008 Oct;90(4):1202.e7-10
pubmed: 18929050
Lancet. 2019 Mar 2;393(10174):899-909
pubmed: 30773280
Fertil Steril. 2016 Dec;106(7):1634-1647
pubmed: 27678032
Can J Gastroenterol Hepatol. 2018 Jul 26;2018:2313675
pubmed: 30148122
Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R69-72
pubmed: 23100030
Dig Liver Dis. 2013 Mar;45(3):226-32
pubmed: 23022423
Am J Gastroenterol. 1999 Apr;94(4):994-9
pubmed: 10201472
Clin Sci (Lond). 2002 May;102(5):587-93
pubmed: 11980579
J Clin Invest. 1998 Dec 1;102(11):1978-85
pubmed: 9835623
Prz Menopauzalny. 2022 Mar;21(1):47-63
pubmed: 35388278
J Gynecol Obstet Hum Reprod. 2021 Apr;50(4):101815
pubmed: 32562778
Eur J Gastroenterol Hepatol. 2002 Jul;14(7):779-82
pubmed: 12169989
Hum Reprod. 1999 Sep;14(9):2249-51
pubmed: 10469689
J Clin Endocrinol Metab. 2021 Jul 13;106(8):2436-2446
pubmed: 33839790
J Obstet Gynaecol. 2017 Jul;37(5):547-549
pubmed: 28319428
Expert Rev Pharmacoecon Outcomes Res. 2021 Aug;21(4):553-558
pubmed: 33784935
J Assist Reprod Genet. 2022 Jan;39(1):219-226
pubmed: 34791588
Hepatobiliary Surg Nutr. 2013 Apr;2(2):68-77
pubmed: 24570919
Pharmacogenetics. 2004 Feb;14(2):91-102
pubmed: 15077010
Sci Rep. 2018 Mar 5;8(1):3985
pubmed: 29507303
Eur J Obstet Gynecol Reprod Biol. 2004 Feb 10;112(2):228-9
pubmed: 14746965
Hum Reprod. 1990 Apr;5(3):348-51
pubmed: 2112558
Gynecol Endocrinol. 2005 Jul;21(1):45-9
pubmed: 16048801
Case Rep Obstet Gynecol. 2019 Dec 27;2019:4980610
pubmed: 32089914
Hum Reprod. 1990 Nov;5(8):938-43
pubmed: 1982004
Am J Gastroenterol. 1998 Jan;93(1):123-4
pubmed: 9448194
Am J Obstet Gynecol. 1972 Apr 15;112(8):1095-100
pubmed: 5025870
J Gastroenterol. 2018 Aug;53(8):945-958
pubmed: 29238877