Gaps and Future Directions in Clinical Research on Obesity-Related Asthma.
Airway inflammation
Asthma
Metabolic dysregulation
Obesity
Journal
Pulmonary therapy
ISSN: 2364-1746
Titre abrégé: Pulm Ther
Pays: United States
ID NLM: 101687144
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
22
03
2023
accepted:
05
06
2023
medline:
18
6
2023
pubmed:
18
6
2023
entrez:
18
6
2023
Statut:
ppublish
Résumé
Obesity is a major comorbidity for the development and worsening of asthma. It is associated with increased disease incidence, reduced response to inhaled and systemic steroids, increased asthma exacerbations, and poor disease control. Over the past two decades, we have learned that there are clinical asthma phenotypes associated with obesity, which have unique immune, inflammatory, and metabolic disease mechanisms. The objectives of this review are to provide a brief overview of the associations and gaps between these chronic inflammatory diseases and the role that traditional therapies have on treating patients with obesity-related asthma, and to describe new clinical research of therapeutic developments targeting mechanisms that are more specific to this patient population.
Identifiants
pubmed: 37330948
doi: 10.1007/s41030-023-00230-2
pii: 10.1007/s41030-023-00230-2
pmc: PMC10447703
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
309-327Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL146542
Pays : United States
Organisme : NHLBI NIH HHS
ID : R33 HL157069
Pays : United States
Organisme : NHLBI NIH HHS
ID : R61 HL157069
Pays : United States
Informations de copyright
© 2023. The Author(s).
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