Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC).
Adenocarcinoma
Alcohol
Cancer
Carcinoid
Diet
Lifestyle
Small intestine
Smoking
Journal
Cancer causes & control : CCC
ISSN: 1573-7225
Titre abrégé: Cancer Causes Control
Pays: Netherlands
ID NLM: 9100846
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
23
02
2023
accepted:
25
05
2023
medline:
28
8
2023
pubmed:
18
6
2023
entrez:
18
6
2023
Statut:
ppublish
Résumé
The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype. We analysed 450,107 participants enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. Cox proportional hazards models were used to estimate univariable and multivariable hazard ratios (HRs) and 95% confidence intervals (CIs). During an average of 14.1 years of follow-up, 160 incident SICs (62 carcinoids, 51 adenocarcinomas) were identified. Whilst univariable models revealed a positive association for current versus never smokers and SIC (HR, 95% CI: 1.77, 1.21-2.60), this association attenuated in multivariable models. In energy-adjusted models, there was an inverse association across vegetable intake tertiles for SIC overall (HR These exploratory analyses found limited evidence for a role of modifiable risk factors in SIC aetiology. However, sample size was limited, particularly for histologic subtypes; therefore, larger studies are needed to delineate these associations and robustly identify risk factors for SIC.
Identifiants
pubmed: 37330982
doi: 10.1007/s10552-023-01731-w
pii: 10.1007/s10552-023-01731-w
pmc: PMC10460357
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
927-937Subventions
Organisme : Cancer Research UK
ID : 25004
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 29017
Pays : United Kingdom
Organisme : Cancer Research UK
ID : PRCRPG-NOV22/100001
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
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