The antagonistic relationship between apoptosis and polyploidy in development and cancer.
Aneuploidy
Apoptosis
Endoreplication
Polyploidy
Regulated cell death
Tetraploid
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
15 Mar 2024
15 Mar 2024
Historique:
received:
07
04
2023
revised:
23
05
2023
accepted:
30
05
2023
medline:
5
12
2023
pubmed:
19
6
2023
entrez:
18
6
2023
Statut:
ppublish
Résumé
One of the important functions of regulated cell death is to prevent cells from inappropriately acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary cell death mechanism that prevents polyploidy, and defects in this apoptotic response can result in polyploid cells whose subsequent error-prone chromosome segregation are a major contributor to genome instability and cancer progression. Conversely, some cells actively repress apoptosis to become polyploid as part of normal development or regeneration. Thus, although apoptosis prevents polyploidy, the polyploid state can actively repress apoptosis. In this review, we discuss progress in understanding the antagonistic relationship between apoptosis and polyploidy in development and cancer. Despite recent advances, a key conclusion is that much remains unknown about the mechanisms that link apoptosis to polyploid cell cycles. We suggest that drawing parallels between the regulation of apoptosis in development and cancer could help to fill this knowledge gap and lead to more effective therapies.
Identifiants
pubmed: 37331841
pii: S1084-9521(23)00126-X
doi: 10.1016/j.semcdb.2023.05.009
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-43Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.