Immunobiology of pregnancy: from basic science to translational medicine.
embryo implantation
feto-maternal interface
immunological self-tolerance
immunology of pregnancy
recurrent implantation failure
regulatory T cells
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
20
02
2023
revised:
20
05
2023
accepted:
22
05
2023
medline:
14
8
2023
pubmed:
19
6
2023
entrez:
18
6
2023
Statut:
ppublish
Résumé
Embryo implantation failure and spontaneous abortions represent the main causes of infertility in developed countries. Unfortunately, incomplete knowledge of the multiple factors involved in implantation and fetal development keeps the success rate of medically assisted procreation techniques relatively low. According to recent literature, cellular and molecular mechanisms of 'immunogenic tolerance' towards the embryo are crucial to establish an 'anti-inflammatory' state permissive of a healthy pregnancy. In this review we dissect the role played by the immune system in the endometrial-embryo crosstalk, with a particular emphasis towards the fork-head-box-p3 (Foxp3
Identifiants
pubmed: 37331882
pii: S1471-4914(23)00099-0
doi: 10.1016/j.molmed.2023.05.009
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
711-725Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests T.D.H. and S.L. declare that they are Merck Healthcare KGaA employees. C.A. declares receipt of unrestricted research grants from Merck and lecture fees from Merck. G.M. reports receiving research grant support from Merck, Biogen, and Novartis and advisory board fees from Merck, Biogen, Novartis, and Roche.