Brain intrinsic magnetic susceptibility mapping depicts whole-brain functional connectivity balance of normal aging in lifespan.
Brain FC aging
Functional connectivity (FC)
MRI effect
Magnetic susceptibility
Summation balance
Tissue magnetization
fMRI magnitude and phase
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
19
02
2023
accepted:
30
05
2023
medline:
13
7
2023
pubmed:
19
6
2023
entrez:
18
6
2023
Statut:
ppublish
Résumé
We hypothesized that brain normal aging maintains a balanced whole-brain functional connectivity (FC) in lifetime: some connections decline while other connections increase or retain, in a summation balance as a result of the cancellation of positive and negative connections. We validated this hypothesis through the use of the brain intrinsic magnetic susceptibility source (denoted by χ) as reconstructed from fMRI phase data. In implementation, we first acquired brain fMRI magnitude (m) and phase (p) data from a cohort of 245 healthy subjects in an age span of 20-60 years, then sought MRI-free brain χ source data by computationally solving an inverse mapping problem, thereby obtained triple datasets {χ, m, p} as brain images in different measurements. We performed GIG-ICA for brain function decomposition and constructed the FC matrices (χFC, mFC, pFC} (in size of 50 × 50 for a selection of 50 ICA nodes), followed by a comparative analysis on brain FC agings using {χ, m, p} data. In the results, we found that: (i) χFC aging upholds a FC balance in life span, in an intermediator between mFC and pFC agings by: mean(pFC) = -0.011 < mean(χFC) = 0.015 < mean(mFC) = 0.036; and (ii) the χFC aging exhibits a slight decline with a slightly downward fitting line in intermediation between the two slightly upward fitting lines for the mFC and pFC agings. On the rationale of the χ-depicted MRI-free brain functional state, the brain χFC aging is closer to the brain FC aging truth than the MRI-borne mFC and pFC agings.
Identifiants
pubmed: 37332061
doi: 10.1007/s00429-023-02661-8
pii: 10.1007/s00429-023-02661-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1443-1458Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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