Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa.
Biochemistry
Biological sciences
Medical biochemistry
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
received:
03
04
2023
revised:
23
04
2023
accepted:
12
05
2023
medline:
19
6
2023
pubmed:
19
6
2023
entrez:
19
6
2023
Statut:
epublish
Résumé
Hidradenitis suppurativa (HS) is a skin disorder that causes chronic painful inflammation and hyperproliferation, often with the comorbidity of invasive keratoacanthoma (KA). Our research, employing high-resolution immunofluorescence and data science approaches together with confirmatory molecular analysis, has identified that the 5'-cap-dependent protein translation regulatory complex eIF4F is a key factor in the development of HS and is responsible for regulating follicular hyperproliferation. Specifically, eIF4F translational targets, Cyclin D1 and c-MYC, orchestrate the development of HS-associated KA. Although eIF4F and
Identifiants
pubmed: 37332597
doi: 10.1016/j.isci.2023.106896
pii: S2589-0042(23)00973-2
pmc: PMC10275975
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106896Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES027723
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA276683
Pays : United States
Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
Authors of this manuscript have no conflict of interest between them or anybody else regarding the scientific contents, financial matters, or otherwise.
Références
Proc Natl Acad Sci U S A. 2018 Mar 06;115(10):E2202-E2209
pubmed: 29463754
JCI Insight. 2020 Oct 2;5(19):
pubmed: 32853177
J Am Acad Dermatol. 1996 Aug;35(2 Pt 1):191-4
pubmed: 8708018
Cytokine. 2017 Jan;89:116-121
pubmed: 27094611
Nat Med. 2002 Oct;8(10):1105-14
pubmed: 12357246
Cancer Res. 2015 Jan 15;75(2):250-63
pubmed: 25593033
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Cell Sci. 2009 Jun 15;122(Pt 12):1933-7
pubmed: 19494120
Int J Surg Case Rep. 2019;55:50-53
pubmed: 30685629
Oncol Lett. 2019 May;17(5):4068-4084
pubmed: 30944600
Nat Rev Drug Discov. 2009 Aug;8(8):627-44
pubmed: 19644473
Cell Cycle. 2013 Aug 1;12(15):2510-7
pubmed: 23839032
Nat Rev Cancer. 2011 Oct 13;11(11):761-74
pubmed: 21993244
N Engl J Med. 2012 Jan 12;366(2):158-64
pubmed: 22236226
Am Surg. 2008 Dec;74(12):1177-81
pubmed: 19097532
Front Immunol. 2020 May 20;11:847
pubmed: 32508815
Nature. 2014 Sep 4;513(7516):105-9
pubmed: 25079330
J Invest Dermatol. 2019 Jan;139(1):124-134
pubmed: 30120935
J Eur Acad Dermatol Venereol. 2021 Jan;35(1):203-210
pubmed: 32978818
SAGE Open Med Case Rep. 2019 May 17;7:2050313X19847359
pubmed: 31205707
J Eur Acad Dermatol Venereol. 2021 Jun;35(6):1386-1392
pubmed: 33559291
J Invest Dermatol. 2020 Oct;140(10):2085-2088.e14
pubmed: 32142795
Br J Dermatol. 2013 Apr;168(4):874-6
pubmed: 23013355
JAMA. 2017 Nov 28;318(20):2019-2032
pubmed: 29183082
Nature. 2017 Jan 26;541(7638):494-499
pubmed: 28077873
J Am Acad Dermatol. 2010 Apr;62(4):706-8, 708.e1
pubmed: 20227585
J Cell Sci. 2021 Jan 13;134(1):
pubmed: 33441326
Nat Commun. 2019 Nov 13;10(1):5151
pubmed: 31723131
Int J Cancer. 2002 Mar 10;98(2):181-5
pubmed: 11857405
BMC Biol. 2019 May 22;17(1):40
pubmed: 31118010
JCI Insight. 2021 Nov 8;6(21):
pubmed: 34546979
Genes Dev. 1997 Nov 1;11(21):2869-82
pubmed: 9353256
Immunol Rev. 2015 Jan;263(1):210-23
pubmed: 25510279
Br J Dermatol. 2016 Aug;175(2):414-6
pubmed: 26879264
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
J Burn Care Res. 2017 Mar/Apr;38(2):121-124
pubmed: 27380120
J Invest Dermatol. 2021 Apr;141(4):742-753.e10
pubmed: 32971126
J Cell Physiol. 2009 Aug;220(2):292-6
pubmed: 19415697
Genes Dev. 2016 Jul 1;30(13):1573-88
pubmed: 27401559
Br J Dermatol. 2016 Mar;174(3):522-32
pubmed: 26473517
J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S1-2
pubmed: 26470607
Nat Med. 2018 Dec;24(12):1877-1886
pubmed: 30374200
Exp Dermatol. 2020 May;29(5):490-498
pubmed: 32049375
Cancer Res. 1991 Aug 1;51(15):4020-7
pubmed: 1906780
N Engl J Med. 2012 Jan 19;366(3):207-15
pubmed: 22256804
JCI Insight. 2020 Oct 2;5(19):
pubmed: 32841223
Cancer Prev Res (Phila). 2010 Mar;3(3):331-8
pubmed: 20145189
J Clin Invest. 2017 Apr 3;127(4):1485-1490
pubmed: 28287404
Oncotarget. 2017 Mar 28;8(13):22203-22217
pubmed: 28108737
Oncogene. 2004 Apr 19;23(18):3189-99
pubmed: 15094768
Cell. 2014 Oct 9;159(2):242-51
pubmed: 25303523
Nat Rev Dis Primers. 2020 Mar 12;6(1):18
pubmed: 32165620