Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemia.
Cell biology
Hematology
Molecular biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
received:
19
09
2022
revised:
22
03
2023
accepted:
19
05
2023
medline:
19
6
2023
pubmed:
19
6
2023
entrez:
19
6
2023
Statut:
epublish
Résumé
The bone marrow (BM) is a complex microenvironment, coordinating the production of billions of blood cells every day. Despite its essential role and its relevance to hematopoietic diseases, this environment remains poorly characterized. Here we present a high-resolution characterization of the niche in health and acute myeloid leukemia (AML) by establishing a single-cell gene expression database of 339,381 BM cells. We found significant changes in cell type proportions and gene expression in AML, indicating that the entire niche is disrupted. We then predicted interactions between hematopoietic stem and progenitor cells (HSPCs) and other BM cell types, revealing a remarkable expansion of predicted interactions in AML that promote HSPC-cell adhesion, immunosuppression, and cytokine signaling. In particular, predicted interactions involving transforming growth factor β1 (TGFB1) become widespread, and we show that this can drive AML cell quiescence
Identifiants
pubmed: 37332612
doi: 10.1016/j.isci.2023.106943
pii: S2589-0042(23)01020-9
pmc: PMC10275994
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106943Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
All authors have reported no financial interests or potential conflicts of interest.
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