All tangled up: interactions of the fibrinolytic and innate immune systems.
fibrinolysis
infection
innate immune
plasminogen
thrombosis
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2023
2023
Historique:
received:
25
04
2023
accepted:
17
05
2023
medline:
19
6
2023
pubmed:
19
6
2023
entrez:
19
6
2023
Statut:
epublish
Résumé
The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens. The awareness of these interlinked process has resulted in the coining of the terms "thromboinflammation" and "immunothrombosis." Once a thrombus is formed it is up to the fibrinolytic system to resolve these clots and remove them from the vasculature. Immune cells contain an arsenal of fibrinolytic regulators and plasmin, the central fibrinolytic enzyme. The fibrinolytic proteins in turn have diverse roles in immunoregulation. Here, the intricate relationship between the fibrinolytic and innate immune system will be discussed.
Identifiants
pubmed: 37332750
doi: 10.3389/fmed.2023.1212201
pmc: PMC10272372
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1212201Informations de copyright
Copyright © 2023 Whyte.
Déclaration de conflit d'intérêts
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Blood. 1984 Oct;64(4):907-13
pubmed: 6434006
PLoS One. 2015 Jul 01;10(7):e0131216
pubmed: 26132730
J Thromb Haemost. 2008 Feb;6(2):268-76
pubmed: 18021301
Am J Med. 1976 Nov;61(5):585-9
pubmed: 984062
Microbiol Immunol. 2002;46(2):131-4
pubmed: 11939578
Front Cardiovasc Med. 2021 Apr 16;8:653655
pubmed: 33937363
Science. 2014 Dec 5;346(6214):1234-8
pubmed: 25477463
World J Surg. 2006 Oct;30(10):1829-34; discussion 1835
pubmed: 16957822
Nat Rev Immunol. 2021 May;21(5):319-329
pubmed: 33824483
Semin Thromb Hemost. 2015 Feb;41(1):9-15
pubmed: 25590524
Nat Med. 2010 Aug;16(8):887-96
pubmed: 20676107
J Clin Invest. 1982 Mar;69(3):536-42
pubmed: 7199538
Br J Haematol. 1988 Nov;70(3):327-33
pubmed: 3264718
J Cell Biol. 1986 Dec;103(6 Pt 1):2411-20
pubmed: 3023400
Am Surg. 2001 Apr;67(4):377-82
pubmed: 11308009
J Cell Biol. 1997 Oct 6;139(1):245-56
pubmed: 9314543
Semin Hematol. 1988 Apr;25(2):84-90
pubmed: 2455348
Crit Care Med. 2001 Jul;29(7):1303-10
pubmed: 11445675
J Clin Med. 2020 Apr 24;9(4):
pubmed: 32344575
Biosci Rep. 2018 Oct 2;38(5):
pubmed: 30166455
Platelets. 2021 Apr 3;32(3):314-324
pubmed: 32896192
Exp Cell Res. 1998 Aug 1;242(2):439-50
pubmed: 9683531
Mediators Inflamm. 2018 May 13;2018:1264913
pubmed: 29950923
Crit Rev Microbiol. 2016 Nov;42(6):866-82
pubmed: 26485450
Nat Rev Immunol. 2013 Jan;13(1):34-45
pubmed: 23222502
J Thromb Haemost. 2014 Oct;12(10):1706-16
pubmed: 25041188
Blood. 2017 Mar 9;129(10):1357-1367
pubmed: 28073784
Nat Med. 1998 Mar;4(3):279-84
pubmed: 9500599
Crit Care Med. 2009 May;37(5):1744-9
pubmed: 19325462
J Biol Chem. 1993 Apr 15;268(11):8284-9
pubmed: 8463338
Thromb Res. 1985 Feb 1;37(3):401-10
pubmed: 2859670
Thromb Haemost. 1995 Dec;74(6):1528-32
pubmed: 8772232
Thromb Haemost. 1992 Sep 7;68(3):315-20
pubmed: 1279832
J Thromb Haemost. 2010 Nov;8(11):2523-9
pubmed: 20723026
Ann N Y Acad Sci. 1992 Dec 4;667:70-80
pubmed: 1285024
N Engl J Med. 2000 May 4;342(18):1334-49
pubmed: 10793167
Blood. 2019 Jul 18;134(3):291-303
pubmed: 31101623
J Clin Invest. 2011 Sep;121(9):3517-27
pubmed: 21804193
Thromb Haemost. 1997 May;77(5):905-10
pubmed: 9184401
Arterioscler Thromb Vasc Biol. 1998 May;18(5):693-701
pubmed: 9598826
J Thromb Haemost. 2016 Apr;14(4):633-44
pubmed: 26786060
J Am Coll Cardiol. 1998 Dec;32(7):2103-4
pubmed: 9857903
Kidney Int. 2009 Jan;75(1):52-9
pubmed: 18800031
Lung. 2012 Apr;190(2):189-98
pubmed: 22037793
Int J Mol Sci. 2021 Feb 08;22(4):
pubmed: 33567773
Cardiol Young. 2016 Jan;26(1):110-5
pubmed: 25682953
Blood. 2014 Jul 31;124(5):679-88
pubmed: 24876560
J Biomed Biotechnol. 2012;2012:272148
pubmed: 23118502
Trans Assoc Am Physicians. 1991;104:21-8
pubmed: 1845147
Cell. 2009 Dec 11;139(6):1143-56
pubmed: 20005807
J Thromb Haemost. 2007 Jul;5 Suppl 1:24-31
pubmed: 17635705
N Engl J Med. 2004 Dec 16;351(25):2611-8
pubmed: 15602021
Semin Respir Crit Care Med. 2006 Aug;27(4):337-49
pubmed: 16909368
Crit Care Med. 2007 Aug;35(8):1821-8
pubmed: 17667242
Eur J Biochem. 1988 Jul 15;175(1):33-9
pubmed: 3136015
Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1495-504
pubmed: 24764453
Circulation. 2003 Feb 18;107(6):869-75
pubmed: 12591758
Eur Cytokine Netw. 1994 May-Jun;5(3):275-81
pubmed: 7948765
J Immunol. 2006 Dec 1;177(11):8171-6
pubmed: 17114493
J Trauma Acute Care Surg. 2020 Jun;88(6):713-714
pubmed: 32281766
Blood. 1995 Nov 1;86(9):3428-35
pubmed: 7579447
Front Immunol. 2019 Jun 28;10:1458
pubmed: 31316511
J Exp Med. 2012 Apr 9;209(4):819-35
pubmed: 22451716
J Clin Invest. 2018 Aug 1;128(8):3356-3368
pubmed: 29723163
J Thromb Haemost. 2004 Jan;2(1):54-7
pubmed: 14717966
Exp Transl Stroke Med. 2015 Jan 27;7:2
pubmed: 25657829
Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L967-75
pubmed: 18836029
J Biol Chem. 1985 Apr 10;260(7):4303-11
pubmed: 3920216
J Immunol. 2003 Jun 1;170(11):5644-51
pubmed: 12759445
Crit Care Med. 2000 Feb;28(2):451-7
pubmed: 10708182
Haematologica. 2021 Feb 01;106(2):522-531
pubmed: 32029503
Semin Thromb Hemost. 2013 Jun;39(4):329-37
pubmed: 23532575
J Infect Dis. 2006 Feb 15;193(4):522-30
pubmed: 16425131
Blood. 2016 Dec 15;128(24):2834-2845
pubmed: 27694320
Blood. 1986 Jul;68(1):275-80
pubmed: 2941084
Nat Rev Cardiol. 2021 Sep;18(9):666-682
pubmed: 33958774
Circulation. 1989 Apr;79(4):920-8
pubmed: 2494006
Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2544-53
pubmed: 26494232
Blood. 2010 May 13;115(19):3980-8
pubmed: 20228273
Clin Sci (Lond). 1995 May;88(5):587-94
pubmed: 7614818
Biochem Biophys Res Commun. 2011 Oct 14;414(1):67-72
pubmed: 21945446
Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L20-8
pubmed: 12730079
Chest. 1995 Jan;107(1):196-200
pubmed: 7813276
Ann Neurol. 2017 Aug;82(2):223-232
pubmed: 28696508
Stroke. 2018 Mar;49(3):754-757
pubmed: 29438080
Blood. 2007 Feb 15;109(4):1593-601
pubmed: 17032919
Int J Mol Sci. 2021 Feb 20;22(4):
pubmed: 33672724
Front Immunol. 2019 Mar 27;10:591
pubmed: 30972077
J Clin Invest. 1987 Nov;80(5):1459-65
pubmed: 3680507
Lancet. 1999 Aug 14;354(9178):556-60
pubmed: 10470700
Thromb Haemost. 2016 Oct 28;116(5):897-903
pubmed: 27610454
Thromb Haemost. 1995 May;73(5):850-6
pubmed: 7482415
Cell. 2015 Feb 12;160(4):631-643
pubmed: 25679759
J Biol Chem. 1983 Apr 10;258(7):4249-56
pubmed: 6833255
Thromb Haemost. 2000 Jun;83(6):887-91
pubmed: 10896243
J Immunol. 2006 Jul 15;177(2):1189-96
pubmed: 16818777
Shock. 2000 Feb;13(2):85-91
pubmed: 10670837
Mol Microbiol. 2003 Mar;47(6):1637-51
pubmed: 12622818
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Front Immunol. 2020 Dec 09;11:573550
pubmed: 33362762
Thromb Haemost. 1996 Jan;75(1):127-33
pubmed: 8713791
J Thromb Haemost. 2010 Jun;8(6):1313-22
pubmed: 20180903
Chest. 2022 Mar;161(3):710-727
pubmed: 34592318
Sci Transl Med. 2017 Sep 27;9(409):
pubmed: 28954929
J Thromb Haemost. 2018 May 20;:
pubmed: 29779246
Blood. 1989 Sep;74(4):1222-5
pubmed: 2504304
Thromb Haemost. 2015 Jun;113(6):1289-98
pubmed: 25789443
Int J Mol Sci. 2021 Jun 19;22(12):
pubmed: 34205443
J Thromb Haemost. 2022 May;20(5):1223-1235
pubmed: 35146910
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1369-74
pubmed: 26787872
J Thromb Haemost. 2022 Oct;20(10):2394-2406
pubmed: 35780481
Lancet. 2006 Apr 1;367(9516):1075-1079
pubmed: 16581406
PLoS One. 2013;8(1):e54883
pubmed: 23382992
Science. 1998 Sep 11;281(5383):1662-5
pubmed: 9733510
Thromb Haemost. 2011 Jun;105(6):999-1009
pubmed: 21505719
Circ Res. 2006 Nov 24;99(11):1261-9
pubmed: 17068293
Blood. 2014 Dec 18;124(26):3982-90
pubmed: 25331118
J Thromb Haemost. 2020 Jul;18(7):1752-1755
pubmed: 32267998
J Thromb Haemost. 2021 Jun;19(6):1546-1557
pubmed: 33826233
PLoS One. 2009 Jun 03;4(6):e5780
pubmed: 19492051
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):903-8
pubmed: 16410357
J Thromb Haemost. 2020 Jul;18(7):1548-1555
pubmed: 32329246
Int J Mol Sci. 2021 Mar 26;22(7):
pubmed: 33810275
Circulation. 2011 Mar 29;123(12):1326-34
pubmed: 21403095
Thromb Haemost. 1999 Jan;81(1):96-103
pubmed: 10348718
Parasitol Res. 2002 Nov;88(11):972-8
pubmed: 12375162
Gut. 2015 Apr;64(4):589-600
pubmed: 24848264
Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22351-22356
pubmed: 32826331
Blood. 2010 Feb 18;115(7):1319-30
pubmed: 19897580
J Vasc Surg. 2009 Nov;50(5):1127-34
pubmed: 19703758
Thromb Haemost. 2008 Dec;100(6):969-75
pubmed: 19132219
PLoS One. 2011 Feb 22;6(2):e17229
pubmed: 21364954
Thorax. 2011 Sep;66(9):788-96
pubmed: 21768189
Immunobiology. 2016 May;221(5):679-89
pubmed: 26822552
PLoS One. 2013 May 02;8(5):e63244
pubmed: 23658816
Front Immunol. 2018 Jun 18;9:1218
pubmed: 29967603
Thromb Res. 1983 Jul 15;31(2):387-90
pubmed: 6636049
J Thromb Haemost. 2014 Sep;12(9):1513-22
pubmed: 25039405
mBio. 2013 Aug 06;4(4):
pubmed: 23919993
Blood. 2017 Sep 14;130(11):1364-1374
pubmed: 28684538
J Biomed Biotechnol. 2012;2012:482096
pubmed: 23118509
Front Immunol. 2019 Nov 05;10:2569
pubmed: 31749809
Blood. 2015 Apr 16;125(16):2568-78
pubmed: 25712989
J Biol Chem. 1982 Mar 25;257(6):2912-9
pubmed: 7199524
Am J Respir Cell Mol Biol. 2013 Oct;49(4):646-53
pubmed: 23721130
Proc Natl Acad Sci U S A. 1985 Aug;82(15):4939-43
pubmed: 2991901
Mol Microbiol. 2013 Aug;89(3):507-17
pubmed: 23763588
J Thromb Haemost. 2020 Sep;18(9):2364-2376
pubmed: 32506822
J Biol Chem. 1984 Dec 10;259(23):14914-21
pubmed: 6438106
N Engl J Med. 1990 Mar 29;322(13):890-7
pubmed: 2314423
PLoS Biol. 2016 May 06;14(5):e1002459
pubmed: 27152726
Blood Adv. 2019 May 28;3(10):1598-1609
pubmed: 31126915
Blood. 2011 Nov 17;118(20):5622-30
pubmed: 21940822
Atherosclerosis. 2013 Nov;231(1):29-38
pubmed: 24125407
J Biol Chem. 1991 Jul 5;266(19):12329-36
pubmed: 1712017
J Biol Chem. 2011 Jul 15;286(28):24544-52
pubmed: 21543325
Blood. 2010 Apr 1;115(13):2674-81
pubmed: 20086247
Haematologica. 2019 Nov 28;105(12):2824-2833
pubmed: 33256381
Thromb Haemost. 1996 Jan;75(1):161-7
pubmed: 8713796
J Clin Invest. 1985 Aug;76(2):528-34
pubmed: 2863285
J Biomed Biotechnol. 2012;2012:141806
pubmed: 23118495
Br J Haematol. 2001 Apr;113(1):72-80
pubmed: 11328284
Int Arch Allergy Immunol. 1994;103(4):400-4
pubmed: 8130654
Blood. 1998 Mar 15;91(6):2005-9
pubmed: 9490683
J Biol Chem. 2011 Dec 16;286(50):43164-71
pubmed: 21976669
Blood. 2021 Jan 14;137(2):248-257
pubmed: 32842150
Int J Mol Sci. 2023 Feb 13;24(4):
pubmed: 36835137
J Immunol. 2005 Nov 15;175(10):6764-71
pubmed: 16272333
Immunity. 2007 Aug;27(2):349-60
pubmed: 17723219
Lancet. 1998 May 16;351(9114):1467-71
pubmed: 9605802
BMJ. 2020 Nov 19;371:m4530
pubmed: 33214134
J Biol Chem. 2013 Mar 8;288(10):6946-56
pubmed: 23293023
Blood. 1981 Dec;58(6):1069-74
pubmed: 7306699