Effects of destruxin A on hemocytes of the domestic silkworm,
Bombyx mori
destruxin A
entomopathogenic fungus
hemocytes
histopathology
target
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2023
2023
Historique:
received:
23
04
2023
accepted:
15
05
2023
medline:
19
6
2023
pubmed:
19
6
2023
entrez:
19
6
2023
Statut:
epublish
Résumé
Destruxin A (DA) is a mycotoxin isolated from the entomopathogenic fungus In this research, the dose-response relationship between DA and morphological changes in body tissues and organs of domestic silkworm, The results showed that responses of individual tissues and organs varied with DA dosage and treatment time. At low doses (i.e., 0.01μg/g), the hemocytes were the most sensitive to DA with morphological changes apparent at 6 h after treatment. However, the muscle cells, fat body, and Malpighian tubules were unaltered. At higher doses (i.e., > 0.1μg/g), morphological changes were observed in muscle cells, fat body, and Malpighian tubules at 24 h after treatment. The results indicated that DA can be an immunosuppressant by damaging host cells like hemocytes, and at higher doses may potentially impact other physiological processes, including muscle function, metabolism, and excretion. The information presented in the current study will facilitate development of mycopesticides and novel immunosuppressants.
Identifiants
pubmed: 37333627
doi: 10.3389/fmicb.2023.1210647
pmc: PMC10272401
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1210647Informations de copyright
Copyright © 2023 Yin, Hu, Li, Yang, Kendra and Hu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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