Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19.
BMI
PASC
T cells
long COVID
post-acute sequelae of COVID-19
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
03
2023
accepted:
16
05
2023
medline:
19
6
2023
pubmed:
19
6
2023
entrez:
19
6
2023
Statut:
epublish
Résumé
The role of adaptive SARS-CoV-2 specific immunity in post-acute sequelae of COVID-19 (PASC) is not well explored, although a growing population of convalescent COVID-19 patients with manifestation of PASC is observed. We analyzed the SARS-CoV-2-specific immune response, via pseudovirus neutralizing assay and multiparametric flow cytometry in 40 post-acute sequelae of COVID-19 patients with non-specific PASC manifestation and 15 COVID-19 convalescent healthy donors. Although frequencies of SARS-CoV-2-reactive CD4+ T cells were similar between the studied cohorts, a stronger SARS-CoV-2 reactive CD8+ T cell response, characterized by IFN
Identifiants
pubmed: 37333646
doi: 10.3389/fmicb.2023.1196721
pmc: PMC10272838
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1196721Informations de copyright
Copyright © 2023 Paniskaki, Konik, Anft, Heidecke, Meister, Pfaender, Krawczyk, Zettler, Jäger, Gaeckler, Dolff, Westhoff, Rohn, Stervbo, Scheibenbogen, Witzke and Babel.
Déclaration de conflit d'intérêts
Author HH was employed by company CellTrend GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
EClinicalMedicine. 2021 Aug;38:101019
pubmed: 34308300
PLoS Pathog. 2022 May 26;18(5):e1010359
pubmed: 35617421
J Virol. 2007 Jun;81(11):5759-65
pubmed: 17376902
Brain Behav Immun Health. 2021 Dec;18:100387
pubmed: 34746876
Trends Immunol. 2022 Apr;43(4):268-270
pubmed: 35272932
Clin Infect Dis. 2023 Feb 8;76(3):e487-e490
pubmed: 36052466
Brain Behav Immun. 2020 Oct;89:594-600
pubmed: 32738287
Int J Infect Dis. 2022 Aug;121:195-202
pubmed: 35584743
Front Immunol. 2022 Jan 25;13:816220
pubmed: 35145522
Nature. 2022 Feb;602(7895):148-155
pubmed: 34875673
Science. 2021 Oct 08;374(6564):eabh1823
pubmed: 34465633
J Thromb Haemost. 2021 Oct;19(10):2546-2553
pubmed: 34375505
Sci Transl Med. 2013 Mar 20;5(177):177ra36
pubmed: 23515078
Nat Rev Immunol. 2022 Jun;22(6):387-397
pubmed: 35484322
Nat Rev Endocrinol. 2020 Jan;16(1):30-43
pubmed: 31776456
Immunity. 2022 Mar 8;55(3):542-556.e5
pubmed: 35151371
Front Microbiol. 2021 Jun 23;12:698169
pubmed: 34248921
Elife. 2022 Mar 23;11:
pubmed: 35318939
Clin Infect Dis. 2022 Apr 9;74(7):1191-1198
pubmed: 34223884
J Neuroinflammation. 2020 Jun 15;17(1):189
pubmed: 32539719
Nat Rev Endocrinol. 2012 Dec;8(12):709-16
pubmed: 22847239
Sci Immunol. 2021 Nov 12;6(65):eabk1741
pubmed: 34591653
Front Med (Lausanne). 2021 Jan 18;7:606824
pubmed: 33537329
Nat Med. 2022 May;28(5):879-882
pubmed: 35383311
Brain Behav Immun. 2021 May;94:138-147
pubmed: 33639239
Sci Transl Med. 2022 Dec 21;14(676):eadd0484
pubmed: 36542694
Mol Ther. 2020 Dec 2;28(12):2691-2702
pubmed: 33186542
Nat Commun. 2021 Jun 30;12(1):4043
pubmed: 34193870
Front Immunol. 2018 Jan 10;8:1960
pubmed: 29375577
Ann Neurol. 2009 Aug;66(2):132-41
pubmed: 19743458
Immunity. 2020 Dec 15;53(6):1258-1271.e5
pubmed: 33296686
J Neurovirol. 2021 Feb;27(1):145-153
pubmed: 33492607
Cell. 2022 Mar 3;185(5):881-895.e20
pubmed: 35216672
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
J Intern Med. 2011 Oct;270(4):327-38
pubmed: 21777306
Front Cell Infect Microbiol. 2022 Apr 05;12:861703
pubmed: 35449732
Brain. 2019 Sep 1;142(9):2549-2551
pubmed: 31497859
Trends Immunol. 2009 Jul;30(7):293-4
pubmed: 19541534
J Transl Med. 2019 Dec 3;17(1):401
pubmed: 31796045
Mol Psychiatry. 2021 Dec;26(12):7475-7480
pubmed: 34285348
EBioMedicine. 2023 Apr;90:104507
pubmed: 36893588
Nat Immunol. 2022 Feb;23(2):210-216
pubmed: 35027728
Diabetes Obes Metab. 2021 Sep;23(9):2183-2188
pubmed: 34060194
Nat Rev Immunol. 2006 Oct;6(10):772-83
pubmed: 16998510
Neurol Neuroimmunol Neuroinflamm. 2022 Mar 7;9(3):
pubmed: 35256481
Front Immunol. 2019 Jul 17;10:1587
pubmed: 31379820
Lancet Psychiatry. 2022 Oct;9(10):815-827
pubmed: 35987197
Lancet Infect Dis. 2021 Jul;21(7):912
pubmed: 33705725
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
Lancet Respir Med. 2021 Nov;9(11):1275-1287
pubmed: 34627560
Front Med (Lausanne). 2021 Jun 18;8:688486
pubmed: 34222292
Brain. 2000 Jun;123 ( Pt 6):1174-83
pubmed: 10825356
J Immunol. 2013 Jul 15;191(2):527-32
pubmed: 23825387