LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function.

Journal

Research (Washington, D.C.)
ISSN: 2639-5274
Titre abrégé: Research (Wash D C)
Pays: United States
ID NLM: 101747148

Informations de publication

Date de publication:
2023
Historique:
received: 17 03 2023
accepted: 29 05 2023
medline: 19 6 2023
pubmed: 19 6 2023
entrez: 19 6 2023
Statut: epublish

Résumé

Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and homeostasis. In particular, the mitochondria-endoplasmic reticulum (ER) membrane contact site (MAM) is known to regulate ion and lipid transfer, as well as signaling and organelle dynamics. However, the regulatory mechanisms of MAM formation and their function are still elusive. Here, we identify mitochondrial Lon protease (LonP1), a highly conserved mitochondrial matrix protease, as a new MAM tethering protein. The removal of LonP1 substantially reduces MAM formation and causes mitochondrial fragmentation. Furthermore, deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER (UPR

Identifiants

DOI: 10.34133/research.0175 PMID: 37333972 PMC: PMC10275618
pubmed: 37333972
doi: 10.34133/research.0175
pii: 0175
pmc: PMC10275618
doi:

Types de publication

Journal Article

Langues

eng

Pagination

0175

Informations de copyright

Copyright © 2023 Yujie Li et al.

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Auteurs

Yujie Li (Y)

The Affiliated Nanhua Hospital and School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan 410008, China.

Dawei Huang (D)

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Lianqun Jia (L)

Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Ministry of Education of China, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, China.

Fugen Shangguan (F)

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Shiwei Gong (S)

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Linhua Lan (L)

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Zhiyin Song (Z)

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.

Juan Xu (J)

Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China.

Chaojun Yan (C)

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.

Tongke Chen (T)

Animal Center, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Yin Tan (Y)

Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Yongzhang Liu (Y)

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Xingxu Huang (X)

School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China.

Carolyn K Suzuki (CK)

Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School-Rutgers, The State University of New Jersey, Newark, NJ, USA.

Zhongzhou Yang (Z)

State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210061, China.

Guanlin Yang (G)

Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Ministry of Education of China, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, China.

Bin Lu (B)

The Affiliated Nanhua Hospital and School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan 410008, China.

Classifications MeSH