Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis.

Mice Animals Pancreatitis / chemically induced Epoxide Hydrolases Acute Disease Enzyme Inhibitors / therapeutic use

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 07 2023
Historique:
medline: 14 7 2023
pubmed: 19 6 2023
entrez: 19 6 2023
Statut: ppublish

Résumé

Acute pancreatitis (AP) is a potentially life-threatening illness characterized by an exacerbated inflammatory response with limited options for pharmacological treatment. Here, we describe the rational development of a library of soluble epoxide hydrolase (sEH) inhibitors for the treatment of AP. Synthesized compounds were screened

Identifiants

DOI: 10.1021/acs.jmedchem.3c00831 PMID: 37334504 PMC: PMC10350924
pubmed: 37334504
doi: 10.1021/acs.jmedchem.3c00831
pmc: PMC10350924
doi:

Substances chimiques

Epoxide Hydrolases EC 3.3.2.-
Enzyme Inhibitors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9201-9222

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Auteurs

Simona Musella (S)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Danilo D'Avino (D)

Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy.
ORCID: 0000-0002-6350-5191

Lukas Klaus Peltner (LK)

Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Philosophenweg 14, D-07743 Jena, Germany.

Veronica Di Sarno (V)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Ida Cerqua (I)

Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy.

Fabrizio Merciai (F)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Vincenzo Vestuto (V)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Tania Ciaglia (T)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Gerardina Smaldone (G)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Francesca Di Matteo (F)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Simone Di Micco (S)

European Biomedical Research Institute (EBRIS), Via S. De Renzi 50, 84125 Salerno, Italy.
ORCID: 0000-0002-4688-1080

Valeria Napolitano (V)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Giuseppe Bifulco (G)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.
ORCID: 0000-0002-1788-5170

Giacomo Pepe (G)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.
ORCID: 0000-0002-7561-2023

Eduardo Maria Sommella (EM)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Manuela Giovanna Basilicata (MG)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.

Giovanna Aquino (G)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.
PhD Program in Drug Discovery and Development, University of Salerno, 84084 Fisciano, SA, Italy.

Isabel M Gomez-Monterrey (IM)

Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy.
ORCID: 0000-0001-6688-2606

Pietro Campiglia (P)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.
European Biomedical Research Institute (EBRIS), Via S. De Renzi 50, 84125 Salerno, Italy.
ORCID: 0000-0002-1069-2181

Carmine Ostacolo (C)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.
ORCID: 0000-0003-3715-8680

Fiorentina Roviezzo (F)

Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy.

Oliver Werz (O)

Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Philosophenweg 14, D-07743 Jena, Germany.
ORCID: 0000-0002-5064-4379

Antonietta Rossi (A)

Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy.

Alessia Bertamino (A)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy.
ORCID: 0000-0002-5482-6276

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Design, Synthesis, and Pharmacological...
questionsmedicales.fr › Eucaryotes › Animaux › Design, Synthesis, and Pharmacological...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du pancréas › Pancréatite › Design, Synthesis, and Pharmacological...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Epoxide hydrolase › Design, Synthesis, and Pharmacological...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie aigüe › Design, Synthesis, and Pharmacological...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Design, Synthesis, and Pharmacological...