The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.
Childhood adversity
Cognition
Family history of psychosis
First episode
Polygenic risk score
Psychosis
Journal
Social psychiatry and psychiatric epidemiology
ISSN: 1433-9285
Titre abrégé: Soc Psychiatry Psychiatr Epidemiol
Pays: Germany
ID NLM: 8804358
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
24
01
2023
accepted:
04
06
2023
medline:
28
8
2023
pubmed:
19
6
2023
entrez:
19
6
2023
Statut:
ppublish
Résumé
This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
Identifiants
pubmed: 37335320
doi: 10.1007/s00127-023-02513-0
pii: 10.1007/s00127-023-02513-0
pmc: PMC10460355
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1573-1580Subventions
Organisme : Medical Research Council
ID : MR/W030608/1
Pays : United Kingdom
Investigateurs
Silvia Amoretti
(S)
Álvaro Andreu-Bernabeu
(Á)
Grégoire Baudin
(G)
Stephanie Beards
(S)
Chiara Bonetto
(C)
Elena Bonora
(E)
Bibiana Cabrera
(B)
Angel Carracedo
(A)
Thomas Charpeaud
(T)
Javier Costas
(J)
Doriana Cristofalo
(D)
Pedro Cuadrado
(P)
Manuel Durán-Cutilla
(M)
Aziz Ferchiou
(A)
David Fraguas
(D)
Nathalie Franke
(N)
Flora Frijda
(F)
Paz Garcia-Portilla
(P)
Javier González Peñas
(J)
Kathryn Hubbard
(K)
Stéphane Jamain
(S)
Estela Jiménez-López
(E)
Marion Leboyer
(M)
Cloe Llorente
(C)
Gonzalo López Montoya
(G)
Esther Lorente-Rovira
(E)
Covadonga M Díaz-Caneja
(C)
Camila Marcelino Loureiro
(C)
Mario Matteis
(M)
Elles Messchaart
(E)
Ma Dolores Moltó
(MD)
Gisela Mezquida
(G)
Carmen Moreno
(C)
Roberto Muratori
(R)
Juan Nacher
(J)
Mara Parellada
(M)
Marta Rapado-Castro
(M)
Mirella Ruggeri
(M)
Jean-Romain Richard
(JR)
José Juan Rodríguez Solano
(JJ)
Pilar A Sáiz
(PA)
Teresa Sánchez-Gutierrez
(T)
Emilio Sánchez
(E)
Franck Schürhoff
(F)
Marco Seri
(M)
Rosana Shuhama
(R)
Fabian Termorshuizen
(F)
Anne-Marie Tronche
(AM)
Daniella van Dam
(D)
Elsje van der Ven
(E)
Informations de copyright
© 2023. The Author(s).
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