Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement.

Humans Transcriptome Neoplasms / pathology Thyroid Neoplasms / genetics Brain Neoplasms / genetics Gene Rearrangement Brain / pathology MicroRNAs / genetics
NTRK brain tumor glioma neurotrophin receptors thyroid cancer

Journal

Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557

Informations de publication

Date de publication:
May 2023
Historique:
received: 18 11 2022
medline: 28 6 2023
pubmed: 19 6 2023
entrez: 19 6 2023
Statut: ppublish

Résumé

For tumors with chimeric NTRK genes, entrectinib and larotrectinib can be prescribed regardless of tumor localization. We compared changes in the transcriptional activity of genes in brain tumors (BT) and thyroid cancer (TC) with rearrangement (NTRK+) and without rearrangement (NTRK-) of the NTRK genes using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We revealed an increase in the transcription of the JUN gene in NTRK+ samples in comparison with NTRK- samples: by 1.6 times for BT (p=0.239) and by 2.5 times for TC (p=0.003). The transcription of eight HOX genes in NTRK+ BT samples was also increased (by 85-725 times, p<0.05) in comparison with NTRK-. In NTRK+ TC samples, the level of miR-31 and miR-542 was statistically significantly higher (by 3 and 2.5 times, respectively) than in NTRK-samples. For the NTRK+ BT samples, the levels of miR-10b, miR-182, and miR-21 more than 5-fold surpassed the corresponding values in NTRK-samples (p<0.05). These findings reflect differences in activation of gene transcription resulting from NTRK gene rearrangement in BT and TC.

Identifiants

DOI: 10.1007/s10517-023-05815-0 PMID: 37335445
pubmed: 37335445
doi: 10.1007/s10517-023-05815-0
pii: 10.1007/s10517-023-05815-0
doi:

Substances chimiques

MicroRNAs 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

78-85

Informations de copyright

© 2023. Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

A A Kechin (AA)

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. aa_kechin@niboch.nsc.ru.
Novosibirsk National Research State University, Novosibirsk, Russia. aa_kechin@niboch.nsc.ru.

M A Koryukov (MA)

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Novosibirsk National Research State University, Novosibirsk, Russia.

M A Smertina (MA)

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

V S Borobova (VS)

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Novosibirsk National Research State University, Novosibirsk, Russia.

I P Oscorbin (IP)

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

A A Ivanov (AA)

Altai Regional Oncological Center, Barnaul, Russia.

S Yu Bakharev (SY)

Altai Regional Oncological Center, Barnaul, Russia.

U A Boyarskikh (UA)

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

N E Kushlinskii (NE)

N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.

M L Filipenko (ML)

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Differences in Transcriptomic Profiles of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Differences in Transcriptomic Profiles of...
questionsmedicales.fr › Tumeurs › Differences in Transcriptomic Profiles of...
questionsmedicales.fr › Maladies endocriniennes › Maladies de la thyroïde › Tumeurs de la thyroïde › Differences in Transcriptomic Profiles of...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Differences in Transcriptomic Profiles of...
questionsmedicales.fr › Phénomènes génétiques › Réarrangement des gènes › Differences in Transcriptomic Profiles of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Differences in Transcriptomic Profiles of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Differences in Transcriptomic Profiles of...