Guanidine-containing double-network silks with enhanced tensile and antibacterial property.
Antibacterial property
Double networks
Silk suture
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
31 Jul 2023
31 Jul 2023
Historique:
received:
14
03
2023
revised:
02
06
2023
accepted:
16
06
2023
medline:
17
7
2023
pubmed:
20
6
2023
entrez:
19
6
2023
Statut:
ppublish
Résumé
The bacterial infection of surgical wounds results in prolonged hospitalization and even death of patients, calling for antibacterial function in modern suture products. To tackle this challenge, cationic guanidine-containing copolymer was synthesized, exhibiting antibacterial potency over 5 log reduction against both Gram-positive S. aureus and Gram-negative E. coli. Furthermore, we developed a double-network silk suture by integrating a guanidine-containing copolymer network into the silk fibroin network. This suture exhibited biocidal activity against S. aureus and E. coli, and superior strength compared to the commercial product in both dry and wet conditions. These results may bring general benefits to public health and medical equipment sustainability.
Identifiants
pubmed: 37336382
pii: S0141-8130(23)02364-4
doi: 10.1016/j.ijbiomac.2023.125470
pii:
doi:
Substances chimiques
Silk
0
Guanidine
JU58VJ6Y3B
Anti-Bacterial Agents
0
Guanidines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
125470Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.