Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy.

Animals Mice Glomerulonephritis, IGA / drug therapy Genome-Wide Association Study Immunoglobulin A / genetics

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
07 2023
Historique:
received: 06 12 2021
accepted: 05 05 2023
medline: 13 7 2023
pubmed: 20 6 2023
entrez: 19 6 2023
Statut: ppublish

Résumé

IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney-biopsy-diagnosed IgAN cases and 28,751 controls across 17 international cohorts. We defined 30 genome-wide significant risk loci explaining 11% of disease risk. A total of 16 loci were new, including TNFSF4/TNFSF18, REL, CD28, PF4V1, LY86, LYN, ANXA3, TNFSF8/TNFSF15, REEP3, ZMIZ1, OVOL1/RELA, ETS1, IGH, IRF8, TNFRSF13B and FCAR. The risk loci were enriched in gene orthologs causing abnormal IgA levels when genetically manipulated in mice. We also observed a positive genetic correlation between IgAN and serum IgA levels. High polygenic score for IgAN was associated with earlier onset of kidney failure. In a comprehensive functional annotation analysis of candidate causal genes, we observed convergence of biological candidates on a common set of inflammatory signaling pathways and cytokine ligand-receptor pairs, prioritizing potential new drug targets.

Identifiants

DOI: 10.1038/s41588-023-01422-x PMID: 37337107
pubmed: 37337107
doi: 10.1038/s41588-023-01422-x
pii: 10.1038/s41588-023-01422-x
doi:

Substances chimiques

Immunoglobulin A 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1091-1105

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK105124
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK082753
Pays : United States
Organisme : NIDDK NIH HHS
ID : RC2 DK116690
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM013061
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008680
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI152960
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK078244
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI149431
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010730
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI130830
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099068
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI024717
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073228
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI150748
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148276
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI150585
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103311
Pays : United States

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.

Références

Feehally, J. et al. HLA has strongest association with IgA nephropathy in genome-wide analysis. J. Am. Soc. Nephrol. 21, 1791–1797 (2010).
pubmed: 20595679 pmcid: 3013538 doi: 10.1681/ASN.2010010076
Gharavi, A. G. et al. Genome-wide association study identifies susceptibility loci for IgA nephropathy. Nat. Genet. 43, 321–327 (2011).
pubmed: 21399633 pmcid: 3412515 doi: 10.1038/ng.787
Kiryluk, K. et al. Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genet. 8, e1002765 (2012).
pubmed: 22737082 pmcid: 3380840 doi: 10.1371/journal.pgen.1002765
Kiryluk, K. et al. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nat. Genet. 46, 1187–1196 (2014).
pubmed: 25305756 pmcid: 4213311 doi: 10.1038/ng.3118
Yu, X. Q. et al. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. Nat. Genet. 44, 178–182 (2012).
doi: 10.1038/ng.1047
Li, M. et al. Identification of new susceptibility loci for IgA nephropathy in Han Chinese. Nat. Commun. 6, 7270 (2015).
pubmed: 26028593 doi: 10.1038/ncomms8270
Li, M. et al. Genome-wide meta-analysis identifies three novel susceptibility loci and reveals ethnic heterogeneity of genetic susceptibility for IgA nephropathy. J. Am. Soc. Nephrol. 31, 2949–2963 (2020).
pubmed: 32912934 pmcid: 7790208 doi: 10.1681/ASN.2019080799
Kiryluk, K., Novak, J. & Gharavi, A. G. Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies. Annu Rev. Med. 64, 339–356 (2013).
pubmed: 23072577 doi: 10.1146/annurev-med-041811-142014
Kiryluk, K. & Novak, J. The genetics and immunobiology of IgA nephropathy. J. Clin. Invest. 124, 2325–2332 (2014).
pubmed: 24892706 pmcid: 4089454 doi: 10.1172/JCI74475
Bulik-Sullivan, B. K. et al. LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291–295 (2015).
pubmed: 25642630 pmcid: 4495769 doi: 10.1038/ng.3211
Feriozzi, S. & Polci, R. The role of tonsillectomy in IgA nephropathy. J. Nephrol. 29, 13–19 (2016).
pubmed: 26582216 doi: 10.1007/s40620-015-0247-4
Liu, L. et al. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits. Nat. Commun. 13, 6859 (2022).
pubmed: 36369178 pmcid: 9651905 doi: 10.1038/s41467-022-34456-6
de Leeuw, C. A., Mooij, J. M., Heskes, T. & Posthuma, D. MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput. Biol. 11, e1004219 (2015).
pubmed: 25885710 pmcid: 4401657 doi: 10.1371/journal.pcbi.1004219
Backenroth, D. et al. FUN-LDA: a latent dirichlet allocation model for predicting tissue-specific functional effects of noncoding variation: methods and applications. Am. J. Hum. Genet. 102, 920–942 (2018).
pubmed: 29727691 pmcid: 5986983 doi: 10.1016/j.ajhg.2018.03.026
Pers, T. H. et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat. Commun. 6, 5890 (2015).
pubmed: 25597830 doi: 10.1038/ncomms6890
Iotchkova, V. et al. GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals. Nat. Genet. 51, 343–353 (2019).
pubmed: 30692680 pmcid: 6908448 doi: 10.1038/s41588-018-0322-6
Harley, J. B. et al. Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity. Nat. Genet. 50, 699–707 (2018).
pubmed: 29662164 pmcid: 6022759 doi: 10.1038/s41588-018-0102-3
Zhou, H. et al. Epstein–Barr virus oncoprotein super-enhancers control B cell growth. Cell Host Microbe 17, 205–216 (2015).
pubmed: 25639793 pmcid: 4539236 doi: 10.1016/j.chom.2014.12.013
Sugai, M., Watanabe, K., Nambu, Y., Hayashi, T. & Shimizu, A. Functions of Runx in IgA class switch recombination. J. Cell. Biochem. 112, 409–414 (2011).
pubmed: 21268061 doi: 10.1002/jcb.22971
Malhotra, N. & Kang, J. SMAD regulatory networks construct a balanced immune system. Immunology 139, 1–10 (2013).
pubmed: 23347175 pmcid: 3634534 doi: 10.1111/imm.12076
Lage, K. et al. A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat. Biotechnol. 25, 309–316 (2007).
pubmed: 17344885 doi: 10.1038/nbt1295
Warde-Farley, D. et al. The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 38, W214–W220 (2010).
pubmed: 20576703 pmcid: 2896186 doi: 10.1093/nar/gkq537
Han, S. S. et al. The role of TNF superfamily member 13 in the progression of IgA nephropathy. J. Am. Soc. Nephrol. 27, 3430–3439 (2016).
pubmed: 27068226 pmcid: 5084881 doi: 10.1681/ASN.2015060677
Yamada, K. et al. Leukemia inhibitory factor signaling enhances production of galactose-deficient IgA1 in IgA nephropathy. Kidney Dis. (Basel) 6, 168–180 (2020).
pubmed: 32523959 doi: 10.1159/000505748
Suzuki, H. et al. Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J. Biol. Chem. 289, 5330–5339 (2014).
pubmed: 24398680 doi: 10.1074/jbc.M113.512277
Yamada, K. et al. Inhibition of STAT3 signaling reduces IgA1 autoantigen production in IgA nephropathy. Kidney Int. Rep. 2, 1194–1207 (2017).
pubmed: 29270528 pmcid: 5733772 doi: 10.1016/j.ekir.2017.07.002
Vosa, U. et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat. Genet. 53, 1300–1310 (2021).
pubmed: 34475573 pmcid: 8432599 doi: 10.1038/s41588-021-00913-z
Owen, C. R., Yuan, L. & Basson, M. D. Smad3 knockout mice exhibit impaired intestinal mucosal healing. Lab. Invest. 88, 1101–1109 (2008).
pubmed: 18711354 pmcid: 3971647 doi: 10.1038/labinvest.2008.77
Yang, X. et al. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J. 18, 1280–1291 (1999).
pubmed: 10064594 pmcid: 1171218 doi: 10.1093/emboj/18.5.1280
Agarwal, S. et al. Human Fc receptor-like 3 inhibits regulatory T cell function and binds secretory IgA. Cell Rep. 30, 1292–1299 (2020).
pubmed: 32023449 doi: 10.1016/j.celrep.2019.12.099
Tolnay, M. Lymphocytes sense antibodies through human FCRL proteins: emerging roles in mucosal immunity. J. Leukoc. Biol. 111, 477–487 (2021).
pubmed: 33884658 doi: 10.1002/JLB.4RU0221-102RR
Choobdar, S. et al. Assessment of network module identification across complex diseases. Nat. Methods 16, 843–852 (2019).
pubmed: 31471613 pmcid: 6719725 doi: 10.1038/s41592-019-0509-5
Zhang, X. et al. An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy. J. Pharm. Biomed. Anal. 156, 221–231 (2018).
pubmed: 29729635 doi: 10.1016/j.jpba.2018.04.048
Zhao, L. et al. Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-kappaB and JAK/STAT signaling pathways in rats. Int. Immunopharmacol. 48, 102–109 (2017).
pubmed: 28499193 doi: 10.1016/j.intimp.2017.05.002
Fulco, C. P. et al. Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations. Nat. Genet. 51, 1664–1669 (2019).
pubmed: 31784727 pmcid: 6886585 doi: 10.1038/s41588-019-0538-0
Fishilevich, S. et al. GeneHancer: genome-wide integration of enhancers and target genes in GeneCards. Database (Oxford) 2017, bax028 (2017).
pubmed: 28605766 doi: 10.1093/database/bax028
Mountjoy, E. et al. An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci. Nat. Genet. 53, 1527–1533 (2021).
pubmed: 34711957 pmcid: 7611956 doi: 10.1038/s41588-021-00945-5
Zipfel, P. F. et al. Complement inhibitors in clinical trials for glomerular diseases. Front. Immunol. 10, 2166 (2019).
pubmed: 31611870 pmcid: 6776600 doi: 10.3389/fimmu.2019.02166
Titze, S. et al. Disease burden and risk profile in referred patients with moderate chronic kidney disease: composition of the German Chronic Kidney Disease (GCKD) cohort. Nephrol. Dial. Transpl. 30, 441–451 (2015).
doi: 10.1093/ndt/gfu294
Wunnenburger, S. et al. Associations between genetic risk variants for kidney diseases and kidney disease etiology. Sci. Rep. 7, 13944 (2017).
pubmed: 29066732 pmcid: 5655008 doi: 10.1038/s41598-017-13356-6
Hansen, I. S., Baeten, D. L. P. & den Dunnen, J. The inflammatory function of human IgA. Cell. Mol. Life Sci. 76, 1041–1055 (2019).
pubmed: 30498997 doi: 10.1007/s00018-018-2976-8
Infante, B. et al. Recurrence of immunoglobulin A nephropathy after kidney transplantation: a narrative review of the incidence, risk factors, pathophysiology and management of immunosuppressive therapy. Clin. Kidney J. 13, 758–767 (2020).
pubmed: 33123355 pmcid: 7577761 doi: 10.1093/ckj/sfaa060
Nelson, M. R. et al. The support of human genetic evidence for approved drug indications. Nat. Genet. 47, 856–860 (2015).
pubmed: 26121088 doi: 10.1038/ng.3314
Robertson, C. C. et al. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nat. Genet. 53, 962–971 (2021).
pubmed: 34127860 pmcid: 8273124 doi: 10.1038/s41588-021-00880-5
Fang, H. et al. A genetics-led approach defines the drug target landscape of 30 immune-related traits. Nat. Genet. 51, 1082–1091 (2019).
pubmed: 31253980 pmcid: 7124888 doi: 10.1038/s41588-019-0456-1
Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).
pubmed: 25722852 pmcid: 4342193 doi: 10.1186/s13742-015-0047-8
Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190–2191 (2010).
pubmed: 20616382 pmcid: 2922887 doi: 10.1093/bioinformatics/btq340
Shi, J. & Lee, S. A novel random effect model for GWAS meta-analysis and its application to trans-ethnic meta-analysis. Biometrics 72, 945–954 (2016).
pubmed: 26916671 pmcid: 4996751 doi: 10.1111/biom.12481
Yang, J. et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, 369–375 (2012).
pubmed: 22426310 pmcid: 3593158 doi: 10.1038/ng.2213
Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76–82 (2011).
pubmed: 21167468 pmcid: 3014363 doi: 10.1016/j.ajhg.2010.11.011
Jia, X. et al. Imputing amino acid polymorphisms in human leukocyte antigens. PLoS ONE 8, e64683 (2013).
pubmed: 23762245 pmcid: 3675122 doi: 10.1371/journal.pone.0064683
Pillai, N. E. et al. Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations. Hum. Mol. Genet. 23, 4443–4451 (2014).
pubmed: 24698974 doi: 10.1093/hmg/ddu149
Ka, S. et al. HLAscan: genotyping of the HLA region using next-generation sequencing data. BMC Bioinformatics 18, 258 (2017).
pubmed: 28499414 pmcid: 5427585 doi: 10.1186/s12859-017-1671-3
Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–575 (2007).
pubmed: 17701901 pmcid: 1950838 doi: 10.1086/519795
Pettersen, E. F. et al. UCSF Chimera—a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605–1612 (2004).
pubmed: 15264254 doi: 10.1002/jcc.20084
1000 Genomes Project Consortium et al. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56–65 (2012).
Tian, C. et al. Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Nat. Commun. 8, 599 (2017).
pubmed: 28928442 pmcid: 5605711 doi: 10.1038/s41467-017-00257-5
Vilhjalmsson, B. J. et al. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. Am. J. Hum. Genet. 97, 576–592 (2015).
pubmed: 26430803 pmcid: 4596916 doi: 10.1016/j.ajhg.2015.09.001
Khera, A. V. et al. Polygenic prediction of weight and obesity trajectories from birth to adulthood. Cell 177, 587–596 (2019).
pubmed: 31002795 pmcid: 6661115 doi: 10.1016/j.cell.2019.03.028
Khera, A. V. et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat. Genet. 50, 1219–1224 (2018).
pubmed: 30104762 pmcid: 6128408 doi: 10.1038/s41588-018-0183-z
Gorski, M. et al. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci. Rep. 7, 45040 (2017).
pubmed: 28452372 pmcid: 5408227 doi: 10.1038/srep45040
Pattaro, C. et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat. Commun. 7, 10023 (2016).
pubmed: 26831199 pmcid: 4735748 doi: 10.1038/ncomms10023
Finucane, H. K. et al. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genet. 47, 1228–1235 (2015).
pubmed: 26414678 pmcid: 4626285 doi: 10.1038/ng.3404
Roadmap Epigenomics Consortium et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317–330 (2015).
Heng, T. S. & Painter, M. W. & Immunological Genome Project Consortium. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 9, 1091–1094 (2008).
Eppig, J. T. et al. The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease. Nucleic Acids Res. 43, D726–D736 (2015).
pubmed: 25348401 doi: 10.1093/nar/gku967
Bult, C. J. et al. Mouse genome database 2016. Nucleic Acids Res. 44, D840–D847 (2016).
pubmed: 26578600 doi: 10.1093/nar/gkv1211
Hormozdiari, F., Kostem, E., Kang, E. Y., Pasaniuc, B. & Eskin, E. Identifying causal variants at loci with multiple signals of association. Genetics 198, 497–508 (2014).
pubmed: 25104515 pmcid: 4196608 doi: 10.1534/genetics.114.167908
Schmiedel, B. J. et al. Impact of genetic polymorphisms on human immune. Cell 175, 1701–1715 (2018).
pubmed: 30449622 pmcid: 6289654 doi: 10.1016/j.cell.2018.10.022
GTEx Consortium. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 45, 580–585 (2013).
Qiu, C. et al. Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease. Nat. Med. 24, 1721–1731 (2018).
pubmed: 30275566 pmcid: 6301011 doi: 10.1038/s41591-018-0194-4
Suhre, K. et al. Human metabolic individuality in biomedical and pharmaceutical research. Nature 477, 54–60 (2011).
pubmed: 21886157 doi: 10.1038/nature10354
Shin, S. Y. et al. An atlas of genetic influences on human blood metabolites. Nat. Genet. 46, 543–550 (2014).
pubmed: 24816252 pmcid: 4064254 doi: 10.1038/ng.2982
Sun, B. B. et al. Genomic atlas of the human plasma proteome. Nature 558, 73–79 (2018).
pubmed: 29875488 pmcid: 6697541 doi: 10.1038/s41586-018-0175-2
Suhre, K. et al. Connecting genetic risk to disease end points through the human blood plasma proteome. Nat. Commun. 8, 14357 (2017).
pubmed: 28240269 pmcid: 5333359 doi: 10.1038/ncomms14357
Emilsson, V. et al. Co-regulatory networks of human serum proteins link genetics to disease. Science 361, 769–773 (2018).
pubmed: 30072576 pmcid: 6190714 doi: 10.1126/science.aaq1327
Giambartolomei, C. et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 10, e1004383 (2014).
pubmed: 24830394 pmcid: 4022491 doi: 10.1371/journal.pgen.1004383
Li, T. et al. A scored human protein-protein interaction network to catalyze genomic interpretation. Nat. Methods 14, 61–64 (2017).
pubmed: 27892958 doi: 10.1038/nmeth.4083
Su, G., Kuchinsky, A., Morris, J. H., States, D. J. & Meng, F. GLay: community structure analysis of biological networks. Bioinformatics 26, 3135–3137 (2010).
pubmed: 21123224 pmcid: 2995124 doi: 10.1093/bioinformatics/btq596
Nepusz, T., Yu, H. & Paccanaro, A. Detecting overlapping protein complexes in protein-protein interaction networks. Nat. Methods 9, 471–472 (2012).
pubmed: 22426491 pmcid: 3543700 doi: 10.1038/nmeth.1938
Szklarczyk, D. et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47, D607–D613 (2019).
pubmed: 30476243 doi: 10.1093/nar/gky1131
Chen, J., Bardes, E. E., Aronow, B. J. & Jegga, A. G. ToppGene suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. 37, W305–W311 (2009).
pubmed: 19465376 pmcid: 2703978 doi: 10.1093/nar/gkp427
Graeber, T. G. & Eisenberg, D. Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression profiles. Nat. Genet. 29, 295–300 (2001).
pubmed: 11685206 doi: 10.1038/ng755
Knox, C. et al. DrugBank 3.0: a comprehensive resource for ‘omics’ research on drugs. Nucleic Acids Res. 39, D1035–D1041 (2011).
pubmed: 21059682 doi: 10.1093/nar/gkq1126
Zhu, F. et al. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 40, D1128–D1136 (2012).
pubmed: 21948793 doi: 10.1093/nar/gkr797
Carvalho-Silva, D. et al. Open targets platform: new developments and updates two years on. Nucleic Acids Res. 47, D1056–D1065 (2019).
pubmed: 30462303 doi: 10.1093/nar/gky1133
Ochoa, D. et al. Open targets platform: supporting systematic drug-target identification and prioritisation. Nucleic Acids Res. 49, D1302–D1310 (2021).
pubmed: 33196847 doi: 10.1093/nar/gkaa1027
Levey, A. S. et al. A new equation to estimate glomerular filtration rate. Ann. Intern. Med. 150, 604–612 (2009).
pubmed: 19414839 pmcid: 2763564 doi: 10.7326/0003-4819-150-9-200905050-00006
Schwartz, G. J. et al. New equations to estimate GFR in children with CKD. J. Am. Soc. Nephrol. 20, 629–637 (2009).
pubmed: 19158356 pmcid: 2653687 doi: 10.1681/ASN.2008030287
Stanaway, I. B. et al. The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype. Genet. Epidemiol. 43, 63–81 (2019).
pubmed: 30298529
Khan, A. et al. Medical records-based genetic studies of the complement system. J. Am. Soc. Nephrol. 32, 2031–2047 (2021).
pubmed: 33941608 pmcid: 8455263 doi: 10.1681/ASN.2020091371
Bycroft, C. et al. The UK Biobank resource with deep phenotyping and genomic data. Nature 562, 203–209 (2018).
pubmed: 30305743 pmcid: 6786975 doi: 10.1038/s41586-018-0579-z
Denny, J. C. et al. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics 26, 1205–1210 (2010).
pubmed: 20335276 pmcid: 2859132 doi: 10.1093/bioinformatics/btq126

Auteurs

Krzysztof Kiryluk (K)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA. kk473@columbia.edu.
Institute for Genomic Medicine, Columbia University, New York City, NY, USA. kk473@columbia.edu.
ORCID: 0000-0002-5047-6715

Elena Sanchez-Rodriguez (E)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
ORCID: 0000-0002-7041-5485

Xu-Jie Zhou (XJ)

Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.

Francesca Zanoni (F)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.

Lili Liu (L)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
ORCID: 0000-0002-2622-9669

Nikol Mladkova (N)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.

Atlas Khan (A)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
ORCID: 0000-0002-6651-2725

Maddalena Marasa (M)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.

Jun Y Zhang (JY)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
ORCID: 0000-0003-4996-8699

Olivia Balderes (O)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.

Simone Sanna-Cherchi (S)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Institute for Genomic Medicine, Columbia University, New York City, NY, USA.
ORCID: 0000-0002-6185-948X

Andrew S Bomback (AS)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
ORCID: 0000-0001-5449-1667

Pietro A Canetta (PA)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
ORCID: 0000-0003-1130-5486

Gerald B Appel (GB)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.

Jai Radhakrishnan (J)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.

Hernan Trimarchi (H)

Nephrology Service, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.

Ben Sprangers (B)

Department of Microbiology and Immunology, Laboratory of Molecular Immunology, KU Leuven, Leuven, Belgium.
Division of Nephrology, University Hospitals Leuven, Leuven, Belgium.
ORCID: 0000-0003-1314-9675

Daniel C Cattran (DC)

Department of Nephrology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.

Heather Reich (H)

Department of Nephrology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.

York Pei (Y)

Department of Nephrology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.

Pietro Ravani (P)

Division of Nephrology, Department of Internal Medicine, University of Calgary, Calgary, Alberta, Canada.

Kresimir Galesic (K)

Zagreb Medical School, Zagreb, Croatia.

Dita Maixnerova (D)

1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.

Vladimir Tesar (V)

1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.
ORCID: 0000-0001-6982-0689

Benedicte Stengel (B)

Centre for Research in Epidemiology and Population Health (CESP), Paris-Saclay University, Versailles Saint Quentin University, INSERM Clinical Epidemiology Team, Villejuif, France.

Marie Metzger (M)

Centre for Research in Epidemiology and Population Health (CESP), Paris-Saclay University, Versailles Saint Quentin University, INSERM Clinical Epidemiology Team, Villejuif, France.

Guillaume Canaud (G)

Université de Paris, Hôpital Necker-Enfants Malades, Paris, France.

Nicolas Maillard (N)

Nephrology, Dialysis, and Renal Transplantation Department, University North Hospital, Saint Etienne, France.

Francois Berthoux (F)

Nephrology, Dialysis, and Renal Transplantation Department, University North Hospital, Saint Etienne, France.

Laureline Berthelot (L)

CRTI, Nantes University, Nantes, France.
ORCID: 0000-0002-9306-9247

Evangeline Pillebout (E)

Center for Research on Inflammation, University of Paris, INSERM and CNRS, Paris, France.

Renato Monteiro (R)

Center for Research on Inflammation, University of Paris, INSERM and CNRS, Paris, France.

Raoul Nelson (R)

Division of Pediatric Nephrology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.

Robert J Wyatt (RJ)

Division of Pediatric Nephrology, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Children's Foundation Research Center, Le Bonheur Children's Hospital, Memphis, TN, USA.

William Smoyer (W)

Division of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, USA.

John Mahan (J)

Division of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, USA.

Al-Akash Samhar (AA)

Division of Pediatric Nephrology, Driscoll Children's Hospital, Corpus Christi, TX, USA.

Guillermo Hidalgo (G)

Division of Pediatric Nephrology, Department of Pediatrics, HMH Hackensack University Medical Center, Hackensack, NJ, USA.

Alejandro Quiroga (A)

Division of Pediatric Nephrology, Helen DeVos Children's Hospital, Grand Rapids, MI, USA.

Patricia Weng (P)

Division of Pediatric Nephrology, Mattel Children's Hospital, Los Angeles, CA, USA.

Raji Sreedharan (R)

Division of Pediatric Nephrology, Medical College of Wisconsin, Milwaukee, WI, USA.

David Selewski (D)

Division of Pediatric Nephrology, Mott Children's Hospital, Ann Arbor, MI, USA.

Keefe Davis (K)

Division of Pediatric Nephrology, Department of Pediatrics, The Medical University of South Carolina (MUSC), Charleston, SC, USA.

Mahmoud Kallash (M)

Division of Pediatric Nephrology, SUNY Buffalo, Buffalo, NY, USA.

Tetyana L Vasylyeva (TL)

Division of Pediatric Nephrology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA.
ORCID: 0000-0003-3236-985X

Michelle Rheault (M)

Division of Pediatric Nephrology, University of Minnesota, Minneapolis, MN, USA.

Aftab Chishti (A)

Division of Pediatric Nephrology, University of Kentucky, Lexington, KY, USA.

Daniel Ranch (D)

Division of Pediatric Nephrology, Department of Pediatrics, University of Kentucky, Lexington, KY, USA.
ORCID: 0000-0002-2702-0218

Scott E Wenderfer (SE)

Division of Pediatric Nephrology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA.
ORCID: 0000-0002-8991-8277

Dmitry Samsonov (D)

Division of Pediatric Nephrology, Boston Children's Hospital, Boston, MA, USA.

Donna J Claes (DJ)

Division of Pediatric Nephrology, Department of Pediatrics, New York Medical College, New York City, NY, USA.

Oleh Akchurin (O)

Division of Pediatric Nephrology, Department of Pediatrics, Weill Cornell Medical College, New York City, NY, USA.
ORCID: 0000-0002-3745-5418

Dimitrios Goumenos (D)

The Aristotle University of Thessaloniki, Thessaloniki, Greece.

Maria Stangou (M)

The Aristotle University of Thessaloniki, Thessaloniki, Greece.
ORCID: 0000-0003-2496-9863

Judit Nagy (J)

2nd Department of Internal Medicine, Nephrological and Diabetological Center, University of Pécs, Pécs, Hungary.

Tibor Kovacs (T)

2nd Department of Internal Medicine, Nephrological and Diabetological Center, University of Pécs, Pécs, Hungary.

Enrico Fiaccadori (E)

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Antonio Amoroso (A)

Department of Medical Sciences, University of Turin, Turin, Italy.
ORCID: 0000-0002-9437-9407

Cristina Barlassina (C)

Renal Division, Dipartimento di Medicina, Chirurgia e Odontoiatria, San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.

Daniele Cusi (D)

Renal Division, Dipartimento di Medicina, Chirurgia e Odontoiatria, San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.

Lucia Del Vecchio (L)

Department of Nephrology and Dialysis, ASST Lariana, Como, Italy.

Giovanni Giorgio Battaglia (GG)

Unità Operativa di Nefrologia e Dialisi, Ospedale di Acireale, Acireale, Italy.

Monica Bodria (M)

University of Messina, Messina, Italy.

Emanuela Boer (E)

Division of Nephrology and Dialysis, Gorizia Hospital, Gorizia, Italy.

Luisa Bono (L)

Nephrology and Dialysis, A.R.N.A.S. Civico and Benfratelli, Palermo, Italy.

Giuliano Boscutti (G)

Nephrology, Dialysis and Renal Transplant Unit, S. Maria della Misericordia Hospital, ASUFC, Udine, Italy.

Gianluca Caridi (G)

Division of Nephrology, Dialysis and Transplantation, IRCCS Giannina Gaslini Institute, Genova, Italy.
ORCID: 0000-0001-6700-3001

Francesca Lugani (F)

Division of Nephrology, Dialysis and Transplantation, IRCCS Giannina Gaslini Institute, Genova, Italy.

GianMarco Ghiggeri (G)

Division of Nephrology, Dialysis and Transplantation, IRCCS Giannina Gaslini Institute, Genova, Italy.
ORCID: 0000-0003-3659-9062

Rosanna Coppo (R)

Regina Margherita Children's Hospital, Torino, Italy.

Licia Peruzzi (L)

Regina Margherita Children's Hospital, Torino, Italy.
ORCID: 0000-0002-5704-3867

Vittoria Esposito (V)

ICS Maugeri SpA, University of Pavia, Pavia, Italy.

Ciro Esposito (C)

ICS Maugeri SpA, University of Pavia, Pavia, Italy.

Sandro Feriozzi (S)

Belcolle Hospital, Viterbo, Italy.

Rosaria Polci (R)

Belcolle Hospital, Viterbo, Italy.

Giovanni Frasca (G)

Division of Nephrology, Dialysis and Renal Transplantation, Riuniti Hospital, Ancona, Italy.

Marco Galliani (M)

Sandro Pertini Hospital, Rome, Italy.

Maurizio Garozzo (M)

Unità Operativa di Nefrologia e Dialisi, Ospedale di Acireale, Acireale, Italy.

Adele Mitrotti (A)

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.

Loreto Gesualdo (L)

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.

Simona Granata (S)

Renal Unit, Department of Medicine, University of Verona, Verona, Italy.

Gianluigi Zaza (G)

Renal Unit, Department of Medicine, University of Verona, Verona, Italy.
ORCID: 0000-0002-6004-6196

Francesco Londrino (F)

S. Andrea Hospital, La Spezia, Italy.

Riccardo Magistroni (R)

Department of Surgical, Medical, Dental, Oncologic and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
ORCID: 0000-0002-3319-0248

Isabella Pisani (I)

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Andrea Magnano (A)

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Carmelita Marcantoni (C)

Nephrology Division, San Marco Hospital, Catania, Italy.

Piergiorgio Messa (P)

Nephrology Dialysis and Kidney Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

Renzo Mignani (R)

Azienda Unità Sanitaria Locale Rimini, Rimini, Italy.

Antonello Pani (A)

Department of Nephrology and Dialysis, G. Brotzu Hospital, Cagliari, Italy.

Claudio Ponticelli (C)

Nephrology and Dialysis, Ospedale Maggiore, Milan, Italy.

Dario Roccatello (D)

Nephrology and Dialysis Unit, G. Bosco Hub Hospital (ERK-net Member) and University of Torino, Torino, Italy.
ORCID: 0000-0002-4419-6813

Maurizio Salvadori (M)

Division of Nephrology and Renal Transplantation, Carreggi Hospital, Florence, Italy.

Erica Salvi (E)

Renal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.

Domenico Santoro (D)

Unit of Nephrology and Dialysis, AOU G Martino, University of Messina, Messina, Italy.

Guido Gembillo (G)

Unit of Nephrology and Dialysis, AOU G Martino, University of Messina, Messina, Italy.

Silvana Savoldi (S)

Unit of Nephrology and Dialysis, ASL TO4-Consultorio Cirié, Turin, Italy.

Donatella Spotti (D)

San Raffaele Hospital, Milan, Italy.

Pasquale Zamboli (P)

NephroCare Italy, Naples, Italy.

Claudia Izzi (C)

Department of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.

Federico Alberici (F)

Department of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.

Elisa Delbarba (E)

Department of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.

Michał Florczak (M)

Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.

Natalia Krata (N)

Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
ORCID: 0000-0003-0564-0819

Krzysztof Mucha (K)

Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
ORCID: 0000-0002-6613-7638

Leszek Pączek (L)

Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.

Stanisław Niemczyk (S)

Department of Internal Disease, Nephrology and Dialysotherapy, Military Institute of Medicine, Warsaw, Poland.

Barbara Moszczuk (B)

Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.

Malgorzata Pańczyk-Tomaszewska (M)

Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

Malgorzata Mizerska-Wasiak (M)

Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

Agnieszka Perkowska-Ptasińska (A)

Department of Pathology, Medical University of Warsaw, Warsaw, Poland.

Teresa Bączkowska (T)

Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.

Magdalena Durlik (M)

Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.

Krzysztof Pawlaczyk (K)

Department of Nephrology, Transplantology and Internal Medicine, Poznan Medical University, Poznan, Poland.

Przemyslaw Sikora (P)

Department of Pediatric Nephrology, Medical University of Lublin, Lublin, Poland.

Marcin Zaniew (M)

Department of Pediatrics, University of Zielona Góra, Zielona Góra, Poland.

Dorota Kaminska (D)

Clinical Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.

Magdalena Krajewska (M)

Clinical Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
ORCID: 0000-0002-2632-2409

Izabella Kuzmiuk-Glembin (I)

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.
ORCID: 0000-0002-0625-148X

Zbigniew Heleniak (Z)

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

Barbara Bullo-Piontecka (B)

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

Tomasz Liberek (T)

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

Alicja Dębska-Slizien (A)

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

Tomasz Hryszko (T)

2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland.
ORCID: 0000-0002-0145-3103

Anna Materna-Kiryluk (A)

Department of Genetics, Medical University of Poznan, Poznan, Poland.

Monika Miklaszewska (M)

Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, Krakow, Poland.

Maria Szczepańska (M)

Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
ORCID: 0000-0001-5336-261X

Katarzyna Dyga (K)

Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.

Edyta Machura (E)

Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.

Katarzyna Siniewicz-Luzeńczyk (K)

Department of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Monika Pawlak-Bratkowska (M)

Department of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Marcin Tkaczyk (M)

Department of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Dariusz Runowski (D)

Department of Nephrology, Kidney Transplantation and Hypertension, Children's Memorial Health Institute, Warsaw, Poland.

Norbert Kwella (N)

Department of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Dorota Drożdż (D)

Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, Krakow, Poland.

Ireneusz Habura (I)

Department of Nephrology, Karol Marcinkowski Hospital, Zielona Góra, Poland.
ORCID: 0000-0001-6936-5428

Florian Kronenberg (F)

Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
ORCID: 0000-0003-2229-1120

Larisa Prikhodina (L)

Division of Inherited and Acquired Kidney Diseases, Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russia.
ORCID: 0000-0002-0702-4932

David van Heel (D)

Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0002-0637-2265

Bertrand Fontaine (B)

Sorbonne University, INSERM, Center of Research in Myology, Institute of Myology, University Hospital Pitie-Salpetriere, Paris, France.
Assistance Publique-Hôpitaux de Paris (AP-HP), Service of Neuro-Myology, University Hospital Pitie-Salpetriere, Paris, France.

Chris Cotsapas (C)

Departments of Neurology and Genetics, Yale University, New Haven, CT, USA.

Cisca Wijmenga (C)

University of Groningen, Groningen, the Netherlands.

Andre Franke (A)

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
ORCID: 0000-0003-1530-5811

Vito Annese (V)

CBP American Hospital, Dubai, United Arab Emirates.

Peter K Gregersen (PK)

Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institutes for Medical Research, North Shore LIJ Health System, New York City, NY, USA.

Sreeja Parameswaran (S)

Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Matthew Weirauch (M)

Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
University of Cincinnati College of Medicine, Cincinnati, OH, USA.
ORCID: 0000-0001-7977-9122

Leah Kottyan (L)

Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
University of Cincinnati College of Medicine, Cincinnati, OH, USA.
ORCID: 0000-0003-3979-2220

John B Harley (JB)

US Department of Veterans Affairs Medical Center and Cincinnati Education and Research for Veterans Foundation, Cincinnati, OH, USA.

Hitoshi Suzuki (H)

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.
ORCID: 0000-0002-1901-2111

Ichiei Narita (I)

Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
ORCID: 0000-0001-7692-3096

Shin Goto (S)

Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Hajeong Lee (H)

Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Dong Ki Kim (DK)

Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
ORCID: 0000-0002-5195-7852

Yon Su Kim (YS)

Biomedical Science, Seoul National University College of Medicine, Seoul, Republic of Korea.

Jin-Ho Park (JH)

Department of Family Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Republic of Korea.
ORCID: 0000-0002-3942-6813

BeLong Cho (B)

Department of Family Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Republic of Korea.
Institute on Aging, Seoul National University College of Medicine, Seoul, Republic of Korea.

Murim Choi (M)

Biomedical Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
ORCID: 0000-0002-9195-1455

Ans Van Wijk (A)

Amsterdam University Medical Centre, VU University Medical Center (VUMC), Amsterdam, the Netherlands.

Ana Huerta (A)

Hospital Universitario Puerta del Hierro Majadahonda, REDINREN, IISCIII, Madrid, Spain.
ORCID: 0000-0003-3342-7628

Elisabet Ars (E)

Molecular Biology Laboratory and Nephrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau, Universitat Autònoma de Barcelona, REDINREN, IISCIII, Barcelona, Spain.
ORCID: 0000-0002-4118-4358

Jose Ballarin (J)

Molecular Biology Laboratory and Nephrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau, Universitat Autònoma de Barcelona, REDINREN, IISCIII, Barcelona, Spain.

Sigrid Lundberg (S)

Department of Nephrology, Danderyd University Hospital, and Department of Clinical Sciences, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-1224-5200

Bruno Vogt (B)

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
ORCID: 0000-0002-1548-6387

Laila-Yasmin Mani (LY)

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
ORCID: 0000-0002-4693-7814

Yasar Caliskan (Y)

Division of Nephrology, Saint Louis University, Saint Louis, MO, USA.

Jonathan Barratt (J)

John Walls Renal Unit, University Hospitals of Leicester, Leicester, UK.

Thilini Abeygunaratne (T)

Salford Royal Hospital, Salford, UK.

Philip A Kalra (PA)

Salford Royal Hospital, Salford, UK.

Daniel P Gale (DP)

Department of Renal Medicine, University College London, London, UK.
ORCID: 0000-0002-9170-1579

Ulf Panzer (U)

University of Hamburg, Hamburg, Germany.

Thomas Rauen (T)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.

Jürgen Floege (J)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.

Pascal Schlosser (P)

Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-8460-0462

Arif B Ekici (AB)

Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
ORCID: 0000-0001-6099-7066

Kai-Uwe Eckardt (KU)

Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
ORCID: 0000-0003-3823-0920

Nan Chen (N)

Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Jingyuan Xie (J)

Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Richard P Lifton (RP)

Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
Laboratory of Human Genetics and Genomics, The Rockefeller University, New York City, NY, USA.

Ruth J F Loos (RJF)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-8532-5087

Eimear E Kenny (EE)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York City, NY, USA.
Center for Population Genomic Health, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Iuliana Ionita-Laza (I)

Department of Biostatistics, Mailman School of Public Health, Columbia University, New York City, NY, USA.
ORCID: 0000-0002-9001-2026

Anna Köttgen (A)

Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-4671-3714

Bruce A Julian (BA)

Departments of Microbiology and Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Jan Novak (J)

Departments of Microbiology and Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
ORCID: 0000-0002-9211-6670

Francesco Scolari (F)

Department of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.

Hong Zhang (H)

Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.

Ali G Gharavi (AG)

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA. ag2239@cumc.columbia.edu.
Institute for Genomic Medicine, Columbia University, New York City, NY, USA. ag2239@cumc.columbia.edu.
ORCID: 0000-0003-2801-233X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Genome-wide association analyses define...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Genome-wide association analyses define...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Glomérulonéphrite à dépôts d'IgA › Genome-wide association analyses define...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-wide association analyses define...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline A › Genome-wide association analyses define...