Vitamin D and diabetic peripheral neuropathy: A multi-centre nerve conduction study among Chinese patients with type 2 diabetes.
diabetic peripheral neuropathy
electromyogram
vitamin D
Journal
Diabetes/metabolism research and reviews
ISSN: 1520-7560
Titre abrégé: Diabetes Metab Res Rev
Pays: England
ID NLM: 100883450
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
revised:
25
04
2023
received:
30
01
2023
accepted:
21
05
2023
medline:
23
10
2023
pubmed:
20
6
2023
entrez:
20
6
2023
Statut:
ppublish
Résumé
Increasing numbers of reports link vitamin D deficiency to diabetic peripheral neuropathy (DPN), yet evidence regarding neurological deficits and electromyogram is scarce. The present multi-centre study sought to investigate these associations based on objective quantifications. Information on DPN-related symptoms, signs, all diabetic microvascular complications, and nerve conduction abilities (quantified by nerve conduction amplitude and velocity, F-wave minimum latency (FML) of peripheral nerves) were collected from a derivation cohort of 1192 patients with type 2 diabetes (T2D). Correlation, regression analysis, and restricted cubic splines (RCS) were used to explore linear and non-linear relationships between vitamin D and DPN, which were validated in an external cohort of 223 patients. Patients with DPN showed lower levels of vitamin D than those without DPN; patients with vitamin D deficiency (<30 nmol/L) tended to suffer more DPN-related neurological deficits (paraesthesia, prickling, abnormal temperature, ankle hyporeflexia, and distal pall hypoesthesia correlating with MNSI-exam score (Y = -0.005306X + 2.105, P = 0.048). Worse nerve conduction abilities (decreased motor nerve amplitude, sensory nerve amplitude, motor nerve velocity, and increased FML) were also observed in these patients. Vitamin D had a significant threshold association with DPN (adjusted OR = 4.136, P = 0.003; RCS P for non-linearity = 0.003) and correlates with other microvascular complications (diabetic retinopathy and diabetic nephropathy). Vitamin D is associated with the conduction ability of peripheral nerves and may have a nerve- and threshold-selective relationship with the prevalence and severity of DPN among patients with T2D.
Substances chimiques
Vitamin D
1406-16-2
Fluorometholone
SV0CSG527L
Types de publication
Multicenter Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3679Informations de copyright
© 2023 John Wiley & Sons Ltd.
Références
Draznin B, Aroda VR, Bakris G, et al. 12. Retinopathy, neuropathy, and foot care: standards of medical care in diabetes-2022. Diabetes Care. 2022;45(Suppl_1):S185-S194. https://doi.org/10.2337/dc22-S012
Brown SJ, Handsaker JC, Bowling FL, Boulton AJ, Reeves ND. Diabetic peripheral neuropathy compromises balance during daily activities. Diabetes Care. 2015;38(6):1116-1122. https://doi.org/10.2337/dc14-1982
Alleman CJ, Westerhout KY, Hensen M, et al. Humanistic and economic burden of painful diabetic peripheral neuropathy in Europe: a review of the literature. Diabetes Res Clin Pract. 2015;109(2):215-225. https://doi.org/10.1016/j.diabres.2015.04.031
Icks A, Scheer M, Morbach S, et al. Time-dependent impact of diabetes on mortality in patients after major lower extremity amputation: survival in a population-based 5-year cohort in Germany. Diabetes Care. 2011;34(6):1350-1354. https://doi.org/10.2337/dc10-2341
Young MJ, Boulton AJ, MacLeod AF, Williams DRR, Sonksen PH. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia. 1993;36(2):150-154. https://doi.org/10.1007/bf00400697
England JD, Gronseth GS, Franklin G, et al. Distal symmetrical polyneuropathy: a definition for clinical research. A report of the American academy of neurology, the American association of electrodiagnostic medicine, and the American academy of physical medicine and rehabilitation. Arch Phys Med Rehabil. 2005;86(1):167-174. https://doi.org/10.1016/j.apmr.2004.09.011
Perkins B, Bril V. Electrophysiologic testing in diabetic neuropathy. Handb Clin Neurol. 2014;126:235-248.
Kimura J. Electrodiagnosis in diseases of nerve and muscle. Princ Pract. 1983:93-97.
Weisman A, Bril V, Ngo M, et al. Identification and prediction of diabetic sensorimotor polyneuropathy using individual and simple combinations of nerve conduction study parameters. PLoS One. 2013;8(3):e58783. https://doi.org/10.1371/journal.pone.0058783
Selvarajah D, Kar D, Khunti K, et al. Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention. Lancet Diabetes Endocrinol. 2019;7(12):938-948. https://doi.org/10.1016/s2213-8587(19)30081-6
Zhu Z, Zhan J, Shao J, et al. High prevalence of vitamin D deficiency among children aged 1 month to 16 years in Hangzhou, China. BMC Publ Health. 2012;12:126. https://doi.org/10.1186/1471-2458-12-126
van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-680. https://doi.org/10.1016/j.beem.2011.06.007
Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016;103(4):1033-1044. https://doi.org/10.3945/ajcn.115.120873
Mogire RM, Mutua A, Kimita W, et al. Prevalence of vitamin D deficiency in Africa: a systematic review and meta-analysis. Lancet Glob Health. 2020;8(1):e134-e142. https://doi.org/10.1016/s2214-109x(19)30457-7
Lips P, Cashman KD, Lamberg-Allardt C, et al. Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society. Eur J Endocrinol. 2019;180(4):P23-p54. https://doi.org/10.1530/eje-18-0736
Cranney A, Horsley T, O'Donnell S, et al. Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess. 2007:1.
Norman AW, Frankel JB, Heldt AM, Grodsky GM. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science. 1980;209(4458):823-825. https://doi.org/10.1126/science.6250216
Boucher BJ, John WG, Noonan K. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004;80(6):1666. author reply 1666-1667. https://doi.org/10.1093/ajcn/80.6.1666
He R, Hu Y, Zeng H, et al. Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with type 2 diabetes. Diabetes Metab Res Rev. 2017;33:e2820. https://doi.org/10.1002/dmrr.2820
Shehab D, Al-Jarallah K, Mojiminiyi OA, Al Mohamedy H, Abdella NA. Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes? Diabet Med. 2012;29(1):43-49. https://doi.org/10.1111/j.1464-5491.2011.03510.x
Lv WS, Zhao WJ, Gong SL, et al. Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis. J Endocrinol Invest. 2015;38(5):513-518. https://doi.org/10.1007/s40618-014-0210-6
Qu GB, Wang LL, Tang X, Wu W, Sun YH. The association between vitamin D level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: an update systematic review and meta-analysis. J Clin Transl Endocrinol. 2017;9:25-31. https://doi.org/10.1016/j.jcte.2017.04.001
Soderstrom LH, Johnson SP, Diaz VA, Mainous AG. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES. Diabet Med. 2012;29(1):50-55. https://doi.org/10.1111/j.1464-5491.2011.03379.x
Alam U, Petropoulos IN, Ponirakis G, et al. Vitamin D deficiency is associated with painful diabetic neuropathy. Diabetes Metab Res Rev. 2021;37(1):e3361. https://doi.org/10.1002/dmrr.3361
Alamdari A, Mozafari R, Tafakhori A, et al. An inverse association between serum vitamin D levels with the presence and severity of impaired nerve conduction velocity and large fiber peripheral neuropathy in diabetic subjects. Neurol Sci. 2015;36(7):1121-1126. https://doi.org/10.1007/s10072-015-2207-0
Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest. 2006;116(8):2062-2072. https://doi.org/10.1172/jci29449
Holick M, Garabédian M. Vitamin D: Photobiology, Metabolism, Mechanism of Action, and Clinical Applications in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. American Society for Bone and Mineral Research; 2006:129-137.
Xiangpeng L, Zengli Z, Honghong Z, et al. Application guideline for vitamin D and bone health in adult Chinese (2014 standard edition) vitamin D working group of osteoporosis committee of China gerontological society. Chin J OsteoporosisZhongguo Guzhi Shusong Zazhi. 2014;20.
Tesfaye S, Boulton AJ, Dyck PJ, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33(10):2285-2293. https://doi.org/10.2337/dc10-1303
Feldman EL, Stevens MJ, Thomas PK, Brown MB, Canal N, Greene DA. A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care. 1994;17(11):1281-1289. https://doi.org/10.2337/diacare.17.11.1281
Dyck PJ, Carter RE, Litchy WJ. Modeling nerve conduction criteria for diagnosis of diabetic polyneuropathy. Muscle Nerve. 2011;44(3):340-345. https://doi.org/10.1002/mus.22074
Dyck PJ. Detection, characterization, and staging of polyneuropathy: assessed in diabetics. Muscle Nerve. 1988;11(1):21-32. https://doi.org/10.1002/mus.880110106
Holick MF. The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017;18(2):153-165. https://doi.org/10.1007/s11154-017-9424-1
Maddaloni E, Cavallari I, Napoli N, Conte C. Vitamin D and diabetes mellitus. Front Horm Res. 2018;50:161-176. https://doi.org/10.1159/000486083
Sandkühler J. Models and mechanisms of hyperalgesia and allodynia. Physiol Rev. 2009;89(2):707-758. https://doi.org/10.1152/physrev.00025.2008
Gottrup H, Nielsen J, Arendt-Nielsen L, Jensen TS. The relationship between sensory thresholds and mechanical hyperalgesia in nerve injury. Pain. 1998;75(2):321-329. https://doi.org/10.1016/s0304-3959(98)00011-6
Määttä LL, Charles M, Witte DR, et al. Prospective study of neuropathic symptoms preceding clinically diagnosed diabetic polyneuropathy: ADDITION-Denmark. Diabetes Care. 2019;42(12):2282-2289. https://doi.org/10.2337/dc19-0869
Xie J, Song W, Liang X, et al. Protective effect of quercetin on streptozotocin-induced diabetic peripheral neuropathy rats through modulating gut microbiota and reactive oxygen species level. Biomed Pharmacother. 2020;127:110147. https://doi.org/10.1016/j.biopha.2020.110147
Kimura J. Long and short of nerve conduction measures: reproducibility for sequential assessments. J Neurol Neurosurg Psychiatry. 2001;71(4):427-430. https://doi.org/10.1136/jnnp.71.4.427
Panayiotopoulos CP, Chroni E. F-waves in clinical neurophysiology: a review, methodological issues and overall value in peripheral neuropathies. Electroencephalogr Clin Neurophysiol. 1996;101(5):365-374. https://doi.org/10.1016/0924-980x(96)95635-0
Fraser JL, Olney RK. The relative diagnostic sensitivity of different F-wave parameters in various polyneuropathies. Muscle Nerve. 1992;15(8):912-918. https://doi.org/10.1002/mus.880150808
Tague SE, Clarke GL, Winter MK, McCarson KE, Wright DE, Smith PG. Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation. J Neurosci. 2011;31(39):13728-13738. https://doi.org/10.1523/jneurosci.3637-11.2011
Wee CL, Mokhtar SS, Banga Singh KK, Rasool AHG. Vitamin D deficiency attenuates endothelial function by reducing antioxidant activity and vascular eNOS expression in the rat microcirculation. Microvasc Res. 2021;138:104227. https://doi.org/10.1016/j.mvr.2021.104227
Karonova T, Stepanova A, Bystrova A, Jude EB. High-dose vitamin D supplementation improves microcirculation and reduces inflammation in diabetic neuropathy patients. Nutrients. 2020;12(9):2518. https://doi.org/10.3390/nu12092518
Chen X, Wan Z, Geng T, et al. Vitamin D status, vitamin D receptor polymorphisms, and risk of microvascular complications among individuals with type 2 diabetes: a prospective study. Diabetes Care. 2023;46:270-277. https://doi.org/10.2337/dc22-0513
Tague SE, Smith PG. Vitamin D deficiency leads to sensory and sympathetic denervation of the rat synovium. Neuroscience. 2014;279:77-93. https://doi.org/10.1016/j.neuroscience.2014.08.035
Riaz S, Malcangio M, Miller M, Tomlinson DR. A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats. Diabetologia. 1999;42(11):1308-1313. https://doi.org/10.1007/s001250051443
Hajiluian G, Nameni G, Shahabi P, Mesgari-Abbasi M, Sadigh-Eteghad S, Farhangi MA. Vitamin D administration, cognitive function, BBB permeability and neuroinflammatory factors in high-fat diet-induced obese rats. Int J Obes. 2017;41(4):639-644. https://doi.org/10.1038/ijo.2017.10
Berridge MJ. Vitamin D: a custodian of cell signalling stability in health and disease. Biochem Soc Trans. 2015;43(3):349-358. https://doi.org/10.1042/bst20140279
Berridge MJ. Vitamin D cell signalling in health and disease. Biochem Biophys Res Commun. 2015;460(1):53-71. https://doi.org/10.1016/j.bbrc.2015.01.008
Rosecrans R, Dohnal JC. Seasonal vitamin D changes and the impact on health risk assessment. Clin Biochem. 2014;47(7-8):670-672. https://doi.org/10.1016/j.clinbiochem.2014.02.004
Mangin M, Sinha R, Fincher K. Inflammation and vitamin D: the infection connection. Inflamm Res. 2014;63(10):803-819. https://doi.org/10.1007/s00011-014-0755-z
Amrein K, Scherkl M, Hoffmann M, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020;74(11):1498-1513. https://doi.org/10.1038/s41430-020-0558-y
Basit A, Basit KA, Fawwad A, et al. Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Res Care. 2016;4(1):e000148. https://doi.org/10.1136/bmjdrc-2015-000148
Shehab D, Al-Jarallah K, Abdella N, Mojiminiyi OA, Al Mohamedy H. Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus. Med Princ Pract. 2015;24(3):250-256. https://doi.org/10.1159/000375304
Ghadiri-Anari A, Mozafari Z, Gholami S, et al. Dose vitamin D supplementations improve peripheral diabetic neuropathy? A before-after clinical trial. Diabetes Metab Syndr. 2019;13(1):890-893. https://doi.org/10.1016/j.dsx.2018.12.014
El-Sawaf ES, Saleh S, Abdallah DM, Ahmed KA, El-Abhar HS. Vitamin D and rosuvastatin obliterate peripheral neuropathy in a type-2 diabetes model through modulating Notch1, Wnt-10α, TGF-β and NRF-1 crosstalk. Life Sci. 2021;279:119697. https://doi.org/10.1016/j.lfs.2021.119697
Dai Q, Zhu X, Manson JE, et al. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. Am J Clin Nutr. 2018;108(6):1249-1258. https://doi.org/10.1093/ajcn/nqy274