Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression.
ADGRB3
AGPCR
BAI3
Schizophrenia
seizure
Journal
Basic & clinical pharmacology & toxicology
ISSN: 1742-7843
Titre abrégé: Basic Clin Pharmacol Toxicol
Pays: England
ID NLM: 101208422
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
revised:
24
05
2023
received:
03
03
2023
accepted:
15
06
2023
medline:
23
10
2023
pubmed:
20
6
2023
entrez:
20
6
2023
Statut:
ppublish
Résumé
Brain-specific angiogenesis inhibitor 3 (ADGRB3/BAI3) belongs to the family of adhesion G protein-coupled receptors. It is most highly expressed in the brain where it plays a role in synaptogenesis and synapse maintenance. Genome-wide association studies have implicated ADGRB3 in disorders such as schizophrenia and epilepsy. Somatic mutations in ADGRB3 have also been identified in cancer. To better understand the in vivo physiological role of ADGRB3, we used CRISPR/Cas9 editing to generate a mouse line with a 7-base pair deletion in Adgrb3 exon 10. Western blot analysis confirmed that homozygous mutants (Adgrb3
Substances chimiques
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
353-363Subventions
Organisme : NCI NIH HHS
ID : R01 CA235162
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096236
Pays : United States
Organisme : NCI NIH HHS
ID : CA235162
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK129968
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120684
Pays : United States
Informations de copyright
© 2023 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd.
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