Liver X Receptor-Inducible Host E3 Ligase IDOL Targets a Human Cytomegalovirus Reactivation Determinant.

Humans Cytomegalovirus / physiology Liver X Receptors Ubiquitin-Protein Ligases / genetics Virus Latency / genetics Viral Proteins / metabolism Lipoproteins, LDL
IDOL LXR UL136 cholesterol cytomegalovirus herpesvirus liver X receptor signaling

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
27 07 2023
Historique:
pmc-release: 20 12 2023
medline: 28 7 2023
pubmed: 20 6 2023
entrez: 20 6 2023
Statut: ppublish

Résumé

Liver X receptor (LXR) signaling broadly restricts virus replication; however, the mechanisms of restriction are poorly defined. Here, we demonstrate that the cellular E3 ligase LXR-inducible degrader of low-density lipoprotein receptor (IDOL) targets the human cytomegalovirus (HMCV) UL136p33 protein for turnover.

Identifiants

DOI: 10.1128/jvi.00758-23 PMID: 37338407 PMC: PMC10373547
pubmed: 37338407
doi: 10.1128/jvi.00758-23
pmc: PMC10373547
doi:

Substances chimiques

Liver X Receptors 0
Ubiquitin-Protein Ligases EC 2.3.2.27
Viral Proteins 0
Lipoproteins, LDL 0
UL136 protein, human herpesvirus 5 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0075823

Subventions

Organisme : NIAID NIH HHS
ID : R37 AI079059
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023074
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI079059
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131598
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG058503
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

Mol Cell Biol. 2013 Apr;33(8):1503-14
pubmed: 23382078
J Virol. 2011 Nov;85(21):11409-21
pubmed: 21880774
Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4558-63
pubmed: 16537413
PLoS Pathog. 2013;9(4):e1003266
pubmed: 23592989
J Virol. 2023 Aug 31;97(8):e0014823
pubmed: 37565749
Trends Endocrinol Metab. 2013 Mar;24(3):129-36
pubmed: 23228326
Adv Virus Res. 2022;112:31-85
pubmed: 35840181
Cytometry B Clin Cytom. 2008 May;74(3):182-8
pubmed: 18383271
Biochem Biophys Res Commun. 2012 Mar 2;419(1):95-8
pubmed: 22326260
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20107-12
pubmed: 22109552
mBio. 2018 Apr 24;9(2):
pubmed: 29691342
EMBO J. 1999 Aug 2;18(15):4299-307
pubmed: 10428968
Nature. 1996 Oct 24;383(6602):728-31
pubmed: 8878485
J Virol. 2011 Dec;85(24):13260-70
pubmed: 21976655
Stroke. 1999 Feb;30(2):299-305
pubmed: 9933263
J Virol. 2018 Sep 26;92(20):
pubmed: 30089695
Sci Adv. 2015 Nov 27;1(10):e1501164
pubmed: 26702450
J Virol. 2012 Mar;86(6):2942-9
pubmed: 22258239
Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):
pubmed: 34903664
J Virol. 1991 Feb;65(2):887-96
pubmed: 1846203
mBio. 2018 Sep 11;9(5):
pubmed: 30206173
Mol Cell Proteomics. 2014 Feb;13(2):397-406
pubmed: 24309898
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):707-11
pubmed: 8380646
J Virol. 2011 Oct;85(19):10286-99
pubmed: 21775459
mSphere. 2021 Jan 6;6(1):
pubmed: 33408225
Anal Biochem. 1999 May 15;270(1):41-9
pubmed: 10328763
Science. 2013 Apr 12;340(6129):199-202
pubmed: 23580527
J Virol. 2013 Oct;87(19):10660-7
pubmed: 23885077
J Virol. 2014 Mar;88(5):2519-29
pubmed: 24352472
Biostat Bioinforma Biomath. 2013 Aug;3(3):71-85
pubmed: 25558171
Exp Hematol. 1999 Feb;27(2):365-9
pubmed: 10029176
J Immunol. 1988 Mar 1;140(5):1625-31
pubmed: 2831271
Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):266-71
pubmed: 9874807
Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20860-20867
pubmed: 32788362
Arch Virol. 2016 Sep;161(9):2491-501
pubmed: 27357231
PLoS Pathog. 2019 Nov 14;15(11):e1008037
pubmed: 31725811
mBio. 2021 Dec 21;12(6):e0226721
pubmed: 34903048
Antiviral Res. 2012 Sep;95(3):245-56
pubmed: 22713431
Virology. 2017 Jan 15;501:119-126
pubmed: 27912080
Virol J. 2016 Oct 22;13(1):179
pubmed: 27770817
Cell. 2004 Jan 23;116(2):181-90
pubmed: 14744430
Cell Host Microbe. 2012 Jul 19;12(1):86-96
pubmed: 22817990
J Lipid Res. 2016 Apr;57(4):574-86
pubmed: 26839333
Virol J. 2018 Feb 6;15(1):31
pubmed: 29409508
BMC Genomics. 2021 Apr 10;22(1):254
pubmed: 33836657
PLoS One. 2013 Aug 26;8(8):e73861
pubmed: 23991206
Virology. 2007 Jun 20;363(1):174-88
pubmed: 17331553
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18764-18770
pubmed: 32694203
J Virol. 2019 Oct 15;93(21):
pubmed: 31391267
Viruses. 2015 Jun 05;7(6):2884-907
pubmed: 26057166
Atherosclerosis. 2015 Sep;242(1):29-36
pubmed: 26164157
PLoS One. 2014 Mar 19;9(3):e92140
pubmed: 24646941
PLoS Pathog. 2016 Oct 3;12(10):e1005918
pubmed: 27698494
J Virol. 1990 Dec;64(12):6154-65
pubmed: 2173785
Methods Mol Biol. 2021;2244:83-101
pubmed: 33555583
J Immunol. 2006 Nov 15;177(10):7303-11
pubmed: 17082649
J Lipid Res. 2020 May;61(5):667-675
pubmed: 31471447
Hepatology. 2012 Apr;55(4):998-1007
pubmed: 22121002
Physiol Rev. 2002 Apr;82(2):373-428
pubmed: 11917093
PLoS Pathog. 2023 Jun 8;19(6):e1011185
pubmed: 37289831
PLoS Pathog. 2011 Dec;7(12):e1002444
pubmed: 22241980
J Virol. 2014 Dec;88(24):14412-25
pubmed: 25297993
Am J Transplant. 2004 Nov;4 Suppl 10:51-8
pubmed: 15504213
PLoS Pathog. 2014 Jun 12;10(6):e1004195
pubmed: 24945302
Lipids Health Dis. 2012 Jul 09;11:69
pubmed: 22676378
J Virol. 2014 Jun;88(11):5987-6002
pubmed: 24623432
Nat Commun. 2016 Mar 31;7:10846
pubmed: 27029405
PLoS One. 2014 Mar 10;9(3):e91359
pubmed: 24614587
Trends Microbiol. 2016 May;24(5):356-365
pubmed: 26946976
Protein Cell. 2015 Apr;6(4):254-64
pubmed: 25682154
mBio. 2016 Mar 01;7(2):e01986
pubmed: 26933055
J Virol. 2011 Oct;85(20):10834-50
pubmed: 21849441
Nat Methods. 2014 Aug;11(8):783-784
pubmed: 25075903
Front Cell Infect Microbiol. 2020 Jul 31;10:368
pubmed: 32850474
Curr Opin Genet Dev. 1998 Oct;8(5):571-5
pubmed: 9794827
J Virol. 2019 Mar 5;93(6):
pubmed: 30602604
Viruses. 2022 Mar 03;14(3):
pubmed: 35336921
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3937-42
pubmed: 9520471
Cell Host Microbe. 2018 May 9;23(5):607-617.e6
pubmed: 29746832
Cell. 1997 Oct 3;91(1):119-26
pubmed: 9335340
Biophys J. 2017 Nov 7;113(9):2110-2120
pubmed: 29117533
Mol Cell Biol. 2011 May;31(9):1885-93
pubmed: 21343340
J Biol Chem. 2010 Jun 25;285(26):19720-6
pubmed: 20427281
Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2541-6
pubmed: 22936343
Front Microbiol. 2022 Mar 07;13:846386
pubmed: 35330771
Cell Host Microbe. 2014 Apr 9;15(4):446-56
pubmed: 24721573
Cell Syst. 2017 Apr 26;4(4):416-429.e3
pubmed: 28365152
Genes Dev. 2007 Oct 1;21(19):2461-72
pubmed: 17908932
mBio. 2021 May 4;12(3):
pubmed: 33947752
J Cell Biochem. 2001;80(3):455-60
pubmed: 11135375
PLoS One. 2007 Apr 11;2(4):e363
pubmed: 17426811
Elife. 2017 Sep 11;6:
pubmed: 28891791
PLoS Pathog. 2016 May 24;12(5):e1005655
pubmed: 27218650
J Gen Virol. 1991 Sep;72 ( Pt 9):2059-64
pubmed: 1654370
PLoS Pathog. 2019 Nov 14;15(11):e1007854
pubmed: 31725809
Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4140-5
pubmed: 15738399
J Virol. 1991 Feb;65(2):897-903
pubmed: 1846204
Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17492-17497
pubmed: 31409717
Virol J. 2005 Feb 23;2:14
pubmed: 15727684
Science. 2009 Jul 3;325(5936):100-4
pubmed: 19520913
J Virol. 2011 Dec;85(23):12750-8
pubmed: 21937636
Biochem J. 2014 Apr 15;459(2):345-54
pubmed: 24438183
J Hepatol. 2007 Mar;46(3):411-9
pubmed: 17156886
mBio. 2018 Jul 17;9(4):
pubmed: 30018108
Mol Cells. 1999 Feb 28;9(1):37-44
pubmed: 10102569
Cell Stem Cell. 2008 Apr 10;2(4):380-91
pubmed: 18397757
Nat Microbiol. 2021 May;6(5):682-696
pubmed: 33558653
Front Cell Infect Microbiol. 2020 Sep 17;10:476
pubmed: 33072616
J Biol Chem. 2016 Feb 26;291(9):4813-25
pubmed: 26719329

Auteurs

Luwanika Mlera (L)

Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.
BIO5 Institute, University of Arizona, Tucson, Arizona, USA.

Donna Collins-McMillen (D)

Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.
BIO5 Institute, University of Arizona, Tucson, Arizona, USA.

Sebastian Zeltzer (S)

Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.
BIO5 Institute, University of Arizona, Tucson, Arizona, USA.

Jason C Buehler (JC)

Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.
BIO5 Institute, University of Arizona, Tucson, Arizona, USA.

Melissa Moy (M)

Graduate Interdisciplinary Program in Cancer Biology, University of Arizona, Tucson, Arizona, USA.

Kristen Zarrella (K)

Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.

Katie Caviness (K)

Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.
BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Graduate Interdisciplinary Program in Genetics, University of Arizona, Tucson, Arizona, USA.

Louis Cicchini (L)

BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA.

David J Tafoya (DJ)

Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.
BIO5 Institute, University of Arizona, Tucson, Arizona, USA.

Felicia Goodrum (F)

Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.
BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Graduate Interdisciplinary Program in Cancer Biology, University of Arizona, Tucson, Arizona, USA.
Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA.
ORCID: 0000-0002-6646-7290

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Liver X Receptor-Inducible Host E3 Ligase IDOL...
questionsmedicales.fr › Virus › Virus à ADN › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › Liver X Receptor-Inducible Host E3 Ligase IDOL...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs hépatiques X › Liver X Receptor-Inducible Host E3 Ligase IDOL...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › Liver X Receptor-Inducible Host E3 Ligase IDOL...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Latence virale › Liver X Receptor-Inducible Host E3 Ligase IDOL...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Liver X Receptor-Inducible Host E3 Ligase IDOL...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines LDL › Liver X Receptor-Inducible Host E3 Ligase IDOL...