Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y

Animals Mice Neuropeptide Y Receptors, Neuropeptide Y / metabolism Structure-Activity Relationship Quantitative Structure-Activity Relationship High-Throughput Screening Assays Obesity Allosteric Regulation

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 07 2023
Historique:
medline: 14 7 2023
pubmed: 20 6 2023
entrez: 20 6 2023
Statut: ppublish

Résumé

Positive allosteric modulators targeting the Y

Identifiants

DOI: 10.1021/acs.jmedchem.3c00383 PMID: 37339079
pubmed: 37339079
doi: 10.1021/acs.jmedchem.3c00383
doi:

Substances chimiques

Neuropeptide Y 0
Receptors, Neuropeptide Y 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8745-8766

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N006763/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM080403
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122010
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA046138
Pays : United States

Auteurs

Corinna Schüß (C)

Institute of Biochemistry, Leipzig University, Leipzig 04103, Germany.

Oanh Vu (O)

Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.

Nigam M Mishra (NM)

Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas 76107, United States.

Iain R Tough (IR)

King's College London, Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, London SE1 1UL, U.K.
ORCID: 0000-0002-4829-9369

Yu Du (Y)

Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.

Jan Stichel (J)

Institute of Biochemistry, Leipzig University, Leipzig 04103, Germany.

Helen M Cox (HM)

King's College London, Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, London SE1 1UL, U.K.

C David Weaver (CD)

Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States.
ORCID: 0000-0002-6886-1195

Jens Meiler (J)

Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Institute for Drug Discovery, Leipzig University, Leipzig 04103, Germany.

Kyle A Emmitte (KA)

Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas 76107, United States.
ORCID: 0000-0002-6643-3947

Annette G Beck-Sickinger (AG)

Institute of Biochemistry, Leipzig University, Leipzig 04103, Germany.
ORCID: 0000-0003-4560-8020

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structure-Activity Relationship Study of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Structure-Activity Relationship Study of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Neuropeptide Y › Structure-Activity Relationship Study of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteur neuropeptide Y › Structure-Activity Relationship Study of the...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structure-Activity Relationship Study of the...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Relation quantitative structure-activité › Structure-Activity Relationship Study of the...
questionsmedicales.fr › Techniques d'investigation › Tests de criblage à haut débit › Structure-Activity Relationship Study of the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Structure-Activity Relationship Study of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Structure-Activity Relationship Study of the...