IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system.
EAE
IL-11
NLRP3 inflammasome
monocyte
multiple sclerosis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
27 06 2023
27 06 2023
Historique:
pmc-release:
20
12
2023
medline:
22
6
2023
pubmed:
20
6
2023
entrez:
20
6
2023
Statut:
ppublish
Résumé
The objective of this study is to examine IL-11-induced mechanisms of inflammatory cell migration to the central nervous system (CNS). We report that IL-11 is produced at highest frequency by myeloid cells among the peripheral blood mononuclear cell (PBMC) subsets. Patients with relapsing-remitting multiple sclerosis (RRMS) have an increased frequency of IL-11
Identifiants
pubmed: 37339207
doi: 10.1073/pnas.2221007120
pmc: PMC10293805
doi:
Substances chimiques
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Interleukin-11
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2221007120Subventions
Organisme : NIAID NIH HHS
ID : R01 AI131238
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107851
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI029564
Pays : United States
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