Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy.

Cryoelectron Microscopy Escherichia coli / metabolism 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / metabolism Scattering, Small Angle X-Rays X-Ray Diffraction Methionine / metabolism Folic Acid / metabolism Vitamin B 12 / metabolism
Enzyme dynamics SAXS cryo-EM one-carbon metabolism structure prediction

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
27 06 2023
Historique:
medline: 22 6 2023
pubmed: 20 6 2023
entrez: 20 6 2023
Statut: ppublish

Résumé

Cobalamin-dependent methionine synthase (MetH) catalyzes the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate (CH

Identifiants

DOI: 10.1073/pnas.2302531120 PMID: 37339208 PMC: PMC10293825
pubmed: 37339208
doi: 10.1073/pnas.2302531120
pmc: PMC10293825
doi:

Substances chimiques

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase EC 2.1.1.13
Methionine AE28F7PNPL
Folic Acid 935E97BOY8
Vitamin B 12 P6YC3EG204

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2302531120

Subventions

Organisme : NIGMS NIH HHS
ID : P30 GM124166
Pays : United States
Organisme : NIGMS NIH HHS
ID : R00 GM100008
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124847
Pays : United States
Organisme : NIH HHS
ID : S10 OD028617
Pays : United States
Organisme : NIGMS NIH HHS
ID : U24 GM129539
Pays : United States
Organisme : NIGMS NIH HHS
ID : K99 GM100008
Pays : United States

Commentaires et corrections

Type : UpdateOf

Références

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Auteurs

Maxwell B Watkins (MB)

Department of Chemistry, Princeton University, Princeton, NJ 08544.
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
ORCID: 0000-0003-4559-2049

Haoyue Wang (H)

Field of Biophysics, Cornell University, Ithaca, NY 14853.
ORCID: 0000-0003-2933-0030

Audrey Burnim (A)

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
ORCID: 0000-0002-9962-1397

Nozomi Ando (N)

Department of Chemistry, Princeton University, Princeton, NJ 08544.
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Field of Biophysics, Cornell University, Ithaca, NY 14853.
ORCID: 0000-0001-7062-1644

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Conformational switching and flexibility in...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Conformational switching and flexibility in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › 5-Methyltetrahydrofolate-homocysteine s-methyltransferase › Conformational switching and flexibility in...
questionsmedicales.fr › Phénomènes physiques › Diffusion de rayonnements › Diffusion aux petits angles › Conformational switching and flexibility in...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement ionisant › Rayons X › Conformational switching and flexibility in...
questionsmedicales.fr › Phénomènes chimiques › Diffraction des rayons X › Conformational switching and flexibility in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Méthionine › Conformational switching and flexibility in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Acide folique › Conformational switching and flexibility in...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Tétrapyrroles › Corrinoïdes › Vitamine B12 › Conformational switching and flexibility in...