Apolipoprotein E is required for brain iron homeostasis in mice.

Mice Animals Hepcidins / genetics Reactive Oxygen Species / metabolism Iron / metabolism Receptors, Transferrin / genetics Homeostasis Brain / metabolism Apolipoproteins E / genetics Apolipoproteins / metabolism
AD and amyloid beta Apolipoprotein E knock-out (ApoE KO/ApoE(−/−)) mice Brain iron metabolism Cytokines Glutathione peroxidase 4 (Gpx4) IRPs and hepcidin Reactive oxygen species (ROS) TfR1 and Fpn1

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
08 2023
Historique:
received: 30 05 2023
accepted: 08 06 2023
medline: 12 7 2023
pubmed: 20 6 2023
entrez: 20 6 2023
Statut: ppublish

Résumé

Apolipoprotein E deficiency (ApoE We investigated iron contents, expression of transferrin receptor 1 (TfR1), ferroportin 1 (Fpn1), iron regulatory proteins (IRPs), aconitase, hepcidin, Aβ42, MAP2, reactive oxygen species (ROS), cytokines and glutathione peroxidase 4 (Gpx4) in the brain of ApoE We demonstrated that ApoE Our findings implied that ApoE is required for brain iron homeostasis and ApoE

Sections du résumé

BACKGROUND
Apolipoprotein E deficiency (ApoE
METHODS
We investigated iron contents, expression of transferrin receptor 1 (TfR1), ferroportin 1 (Fpn1), iron regulatory proteins (IRPs), aconitase, hepcidin, Aβ42, MAP2, reactive oxygen species (ROS), cytokines and glutathione peroxidase 4 (Gpx4) in the brain of ApoE
RESULTS
We demonstrated that ApoE
CONCLUSIONS
Our findings implied that ApoE is required for brain iron homeostasis and ApoE

Identifiants

DOI: 10.1016/j.redox.2023.102779 PMID: 37339558 PMC: PMC10363452
pubmed: 37339558
pii: S2213-2317(23)00180-5
doi: 10.1016/j.redox.2023.102779
pmc: PMC10363452
pii:
doi:

Substances chimiques

Hepcidins 0
Reactive Oxygen Species 0
Iron E1UOL152H7
Receptors, Transferrin 0
Apolipoproteins E 0
Apolipoproteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102779

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest No conflict of interest.

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Auteurs

Juan Ma (J)

Department of Neurology, Affiliated Hospital, and Institute of Translational and Precision Medicine, Nantong University, 19 Qi Xiu Road, Nantong, Jiangsu, 226001, China; Laboratory of Neuropharmacology of Pharmacy School, and National Clinical Research Center for Aging and Medicine of Huashan Hospital, Fudan University, Shanghai, 201203, China. Electronic address: mj19890412@126.com.

Qian Guo (Q)

Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, 881 Yonghe Road, Nantong, Jiangsu, 226001, China; Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 99 Shangda Road, Shanghai, 200444, China. Electronic address: qian_guo@shu.edu.cn.

Meng-Qi Shen (MQ)

Department of Neurology, Affiliated Hospital, and Institute of Translational and Precision Medicine, Nantong University, 19 Qi Xiu Road, Nantong, Jiangsu, 226001, China. Electronic address: MQ0624@163.com.

Wei Li (W)

Department of Neurology, Affiliated Hospital, and Institute of Translational and Precision Medicine, Nantong University, 19 Qi Xiu Road, Nantong, Jiangsu, 226001, China. Electronic address: liweinantong@163.com.

Qi-Xin Zhong (QX)

Department of Cardiovascular Medicine, Shenzhen Hospital, Guangzhou University of Chinese Medicine, Shenzhen, 518034, China. Electronic address: zhongqixin2022@163.com.

Zhong-Ming Qian (ZM)

Department of Neurology, Affiliated Hospital, and Institute of Translational and Precision Medicine, Nantong University, 19 Qi Xiu Road, Nantong, Jiangsu, 226001, China. Electronic address: zhongmingqian2022@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Apolipoprotein E is required for brain iron...
questionsmedicales.fr › Eucaryotes › Animaux › Apolipoprotein E is required for brain iron...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Hepcidines › Apolipoprotein E is required for brain iron...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Apolipoprotein E is required for brain iron...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Apolipoprotein E is required for brain iron...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à la transferrine › Apolipoprotein E is required for brain iron...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Apolipoprotein E is required for brain iron...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Apolipoprotein E is required for brain iron...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotein E is required for brain iron...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotein E is required for brain iron...