Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort.
Fungal burden
Immunosuppression
Non-HIV PCP
Pneumocystis jirovecii
Semiquantitative real-time PCR
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
15
02
2023
revised:
12
06
2023
accepted:
13
06
2023
medline:
9
8
2023
pubmed:
21
6
2023
entrez:
20
6
2023
Statut:
ppublish
Résumé
This study aimed to explore the role of fungal burden in risk stratification of patients without HIV-negative patients with Pneumocystis pneumonia (PCP). This was a retrospective analysis of the characteristics associated with 30-day mortality in patients who were positive for P. jirovecii using polymerase chain reaction in bronchoalveolar lavage fluid between 2006 and 2017 in a multicenter cohort from Central Norway. The fungal burden was indicated by the cycle threshold (C We included 170 patients with proven or probable PCP. The all-cause 30-day mortality was 18.2%. After adjusting for host characteristics and premorbid corticosteroid use, a higher fungal burden was associated with a higher risk of dying: adjusted odds ratio 1.42 (95% confidence interval 0.48-4.25) for a C Fungal burden may improve the risk stratification of patients without HIV-negative patients with PCP.
Identifiants
pubmed: 37339716
pii: S1201-9712(23)00637-9
doi: 10.1016/j.ijid.2023.06.013
pii:
doi:
Types de publication
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
177-186Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declarations of competing interest The authors have no competing interests to declare.