Human Epidermal Growth Factor Receptor 2/Human Epidermal Growth Factor Receptor 3 PET Imaging: Challenges and Opportunities.

Female Humans Breast Neoplasms / diagnostic imaging Positron-Emission Tomography / methods Receptor, ErbB-2 Receptor, ErbB-3
Antibody Breast cancer Molecular imaging Nanobody Peptide Pertuzumab Trastuzumab

Journal

PET clinics
ISSN: 1879-9809
Titre abrégé: PET Clin
Pays: United States
ID NLM: 101260152

Informations de publication

Date de publication:
Oct 2023
Historique:
medline: 4 9 2023
pubmed: 21 6 2023
entrez: 20 6 2023
Statut: ppublish

Résumé

Human epidermal growth factor receptor 2 (HER2) and HER3 provide actionable targets for both therapy and imaging in breast cancer. Further, clinical trials have shown the prognostic impact of receptor status discordance in breast cancer. Intra- and intertumoral heterogeneity of both HER and hormone receptor expression contributes to inherent errors in tissue sampling, and single biopsies are incapable of identifying discordance in biomarker expression. Numerous PET radiopharmaceuticals have been developed to evaluate (or target for therapy) HER2 and HER3 expression. This review seeks to inform on challenges and opportunities in HER2 and HER3 PET imaging in both clinical and preclinical settings.

Identifiants

DOI: 10.1016/j.cpet.2023.04.009 PMID: 37339919
pubmed: 37339919
pii: S1556-8598(23)00051-2
doi: 10.1016/j.cpet.2023.04.009
pii:
doi:

Substances chimiques

ERBB2 protein, human EC 2.7.10.1
Receptor, ErbB-2 EC 2.7.10.1
ERBB3 protein, human EC 2.7.10.1
Receptor, ErbB-3 EC 2.7.10.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

543-555

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Maxwell Ducharme (M)

Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Ameer Mansur (A)

Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.

Luke Sligh (L)

Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Gary A Ulaner (GA)

Molecular Imaging and Therapy, Hoag Family Cancer Institute, Irvine, CA, USA; Department of Radiology and Translational Genomics, University of Southern California, Los Angeles, CA, USA.

Suzanne E Lapi (SE)

Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: lapi@uab.edu.

Anna G Sorace (AG)

Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: asorace@uabmc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Human Epidermal Growth Factor Receptor 2/Human...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Human Epidermal Growth Factor Receptor 2/Human...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Human Epidermal Growth Factor Receptor 2/Human...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Récepteur ErbB-2 › Human Epidermal Growth Factor Receptor 2/Human...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Récepteur ErbB-3 › Human Epidermal Growth Factor Receptor 2/Human...