Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma.
EGF-family ligands
ERBB receptors
Kras
PDAC
Panc-1
decoy molecule
mouse model
Journal
Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
11
05
2023
received:
17
10
2022
accepted:
19
06
2023
medline:
3
11
2023
pubmed:
21
6
2023
entrez:
21
6
2023
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of cancers. Attempts to develop targeted therapies still need to be established. Some oncogenic mechanisms in PDAC carcinogenesis harness the EGFR/ERBB receptor family. To explore the effects on pancreatic lesions, we attempted simultaneous blockade of all ERBB ligands in a PDAC mouse model. To this end, we engineered a molecular decoy, TRAP-F
Identifiants
pubmed: 37341059
doi: 10.1002/1878-0261.13473
pmc: PMC10620123
doi:
Substances chimiques
Ligands
0
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Receptor, ErbB-4
EC 2.7.10.1
EGFR protein, mouse
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2415-2431Informations de copyright
© 2023 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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