Spatial frequency domain imaging for the assessment of scleroderma skin involvement.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Jun 2023
01 Jun 2023
Historique:
received:
10
03
2023
revised:
11
05
2023
accepted:
11
05
2023
medline:
21
6
2023
pubmed:
21
6
2023
entrez:
21
6
2023
Statut:
epublish
Résumé
Systemic sclerosis (SSc) is an autoimmune disease characterized by the widespread deposition of excess collagen in the skin and internal organs, as well as vascular dysfunction. The current standard of care technique used to quantify the extent of skin fibrosis in SSc patients is the modified Rodnan skin score (mRSS), which is an assessment of skin thickness based on clinical palpation. Despite being considered the gold standard, mRSS testing requires a trained physician and suffers from high inter-observer variability. In this study, we evaluated the use of spatial frequency domain imaging (SFDI) as a more quantitative and reliable method for assessing skin fibrosis in SSc patients. SFDI is a wide-field and non-contact imaging technique that utilizes spatially modulated light to generate a map of optical properties in biological tissue. The SFDI data were collected at six measurement sites (left and right forearms, hands, and fingers) of eight control subjects and ten SSc patients. mRSS were assessed by a physician, and skin biopsies were collected from subject's forearms and used to assess for markers of skin fibrosis. Our results indicate that SFDI is sensitive to skin changes even at an early stage, as we found a significant difference in the measured optical scattering (
Identifiants
pubmed: 37342706
doi: 10.1364/BOE.489609
pii: 489609
pmc: PMC10278615
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2955-2968Informations de copyright
© 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.
Déclaration de conflit d'intérêts
A.P., A.M., K.K., A.B. and D.R. have submitted a patent disclosure related to the technology in this publication.
Références
Biomed Opt Express. 2016 May 24;7(6):2373-84
pubmed: 27375952
Optica. 2016 Jun 20;3(6):613-621
pubmed: 27547790
Ann Rheum Dis. 2010 Jun;69(6):1140-3
pubmed: 19762365
Ann Rheum Dis. 2019 May;78(5):648-656
pubmed: 30852552
Opt Lett. 2005 Jun 1;30(11):1354-6
pubmed: 15981531
Neoplasia. 2021 Mar;23(3):294-303
pubmed: 33578267
J Biomed Opt. 2015 May;20(5):50801
pubmed: 25992845
J Biophotonics. 2019 Jun;12(6):e201800379
pubmed: 30706695
Lasers Surg Med. 2009 Aug;41(6):442-53
pubmed: 19588528
J Biomed Opt. 2009 Mar-Apr;14(2):024012
pubmed: 19405742
Clin Exp Rheumatol. 2010 Mar-Apr;28(2 Suppl 58):S37-41
pubmed: 20576212
Lancet. 1986 Feb 8;1(8476):307-10
pubmed: 2868172
Rheum Dis Clin North Am. 2008 Feb;34(1):1-15; v
pubmed: 18329529
Biomed Opt Express. 2016 Sep 19;7(10):4154-4170
pubmed: 27867722
J Biophotonics. 2019 Dec;12(12):e201900236
pubmed: 31343837
Arthritis Rheum. 2007 Jul;56(7):2422-31
pubmed: 17599771
Lasers Surg Med. 2012 Oct;44(8):611-21
pubmed: 22911574
Clin Exp Immunol. 2011 Feb;163(2):235-41
pubmed: 21091669
Am J Pathol. 1990 Sep;137(3):585-91
pubmed: 1698026
Rev Sci Instrum. 2017 Sep;88(9):094302
pubmed: 28964218
Arthritis Rheum. 2008 May 15;59(5):699-705
pubmed: 18438905
Curr Opin Rheumatol. 2021 Mar 1;33(2):122-127
pubmed: 33481429
Rheumatology (Oxford). 2009 Sep;48(9):1143-6
pubmed: 19605370
J Biomed Opt. 2018 Sep;24(7):
pubmed: 30218504
J Scleroderma Relat Disord. 2017 Jan-Apr;2(1):11-18
pubmed: 28516167
Int J Rheum Dis. 2019 Dec;22(12):2096-2107
pubmed: 31621157
J Biomed Opt. 2021 Feb;26(2):
pubmed: 33569936
Ann Rheum Dis. 2007 Jul;66(7):966-9
pubmed: 17234649
Ann Rheum Dis. 2013 Nov;72(11):1845-51
pubmed: 23426041
J Rheumatol. 2003 Jul;30(7):1630-47
pubmed: 12858472
N Engl J Med. 2009 May 7;360(19):1989-2003
pubmed: 19420368
Arthritis Rheum. 2006 Nov;54(11):3655-60
pubmed: 17075814
Perspect Med Educ. 2016 Apr;5(2):122-124
pubmed: 26984161
J Biomed Opt. 2016 Apr 30;21(4):46002
pubmed: 27048877
J Invest Dermatol. 1985 Jul;85(1):38-42
pubmed: 4008975
Br J Dermatol. 2012 Dec;167(6):1215-23
pubmed: 22804872