Metabolic Imaging as a Tool to Characterize Chemoresistance and Guide Therapy in Triple-Negative Breast Cancer (TNBC).
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
02 10 2023
02 10 2023
Historique:
received:
16
12
2022
revised:
07
04
2023
accepted:
15
06
2023
pmc-release:
02
04
2024
medline:
3
10
2023
pubmed:
21
6
2023
entrez:
21
6
2023
Statut:
ppublish
Résumé
After an initial response to chemotherapy, tumor relapse is frequent. This event is reflective of both the spatiotemporal heterogeneities of the tumor microenvironment as well as the evolutionary propensity of cancer cell populations to adapt to variable conditions. Because the cause of this adaptation could be genetic or epigenetic, studying phenotypic properties such as tumor metabolism is useful as it reflects molecular, cellular, and tissue-level dynamics. In triple-negative breast cancer (TNBC), the characteristic metabolic phenotype is a highly fermentative state. However, during treatment, the spatial and temporal dynamics of the metabolic landscape are highly unstable, with surviving populations taking on a variety of metabolic states. Thus, longitudinally imaging tumor metabolism provides a promising approach to inform therapeutic strategies, and to monitor treatment responses to understand and mitigate recurrence. Here we summarize some examples of the metabolic plasticity reported in TNBC following chemotherapy and review the current metabolic imaging techniques available in monitoring chemotherapy responses clinically and preclinically. The ensemble of imaging technologies we describe has distinct attributes that make them uniquely suited for a particular length scale, biological model, and/or features that can be captured. We focus on TNBC to highlight the potential of each of these technological advances in understanding evolution-based therapeutic resistance.
Identifiants
pubmed: 37343066
pii: 727392
doi: 10.1158/1541-7786.MCR-22-1004
pmc: PMC10592445
mid: NIHMS1912848
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
995-1009Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB028148
Pays : United States
Informations de copyright
©2023 American Association for Cancer Research.
Références
J Clin Oncol. 2006 Dec 20;24(36):5652-7
pubmed: 17116942
Nat Med. 2016 Apr;22(4):427-32
pubmed: 26950360
Cell Rep. 2022 May 31;39(9):110870
pubmed: 35649368
Front Oncol. 2020 Mar 27;10:373
pubmed: 32292719
Radiol Imaging Cancer. 2021 Sep;3(5):e200155
pubmed: 34477453
Springerplus. 2014 Oct 27;3:634
pubmed: 25932360
Front Oncol. 2020 May 15;10:553
pubmed: 32500020
Cell Rep. 2016 Mar 8;14(9):2154-2165
pubmed: 26923594
J Biomed Opt. 2006 Nov-Dec;11(6):064012
pubmed: 17212535
Immune Netw. 2012 Dec;12(6):223-9
pubmed: 23396713
J Nucl Med. 2016 Apr;57(4):536-43
pubmed: 26697967
Biomed Pharmacother. 2019 Nov;119:109454
pubmed: 31526971
Nat Cell Biol. 2019 Apr;21(4):498-510
pubmed: 30936474
Cell Rep. 2018 Feb 20;22(8):1945-1955
pubmed: 29466723
J Clin Oncol. 2021 Jul 10;39(20):2247-2256
pubmed: 33999652
Clin Transl Radiat Oncol. 2019 Jan 18;15:62-69
pubmed: 30734002
J Med Chem. 2020 Dec 10;63(23):14276-14307
pubmed: 33103432
J Nucl Med. 1998 Feb;39(2):250-4
pubmed: 9476930
PLoS One. 2018 May 23;13(5):e0197754
pubmed: 29791503
J Nucl Med. 2009 May;50 Suppl 1:55S-63S
pubmed: 19380410
Radiol Imaging Cancer. 2020 Jul 31;2(4):e200017
pubmed: 32803167
Cancer Res. 2013 Mar 1;73(5):1524-35
pubmed: 23288510
Cancer Res. 2014 Sep 15;74(18):5184-94
pubmed: 25100563
Circulation. 2011 Oct 4;124(14):1580-94
pubmed: 21969318
Sci Rep. 2017 Oct 23;7(1):13772
pubmed: 29062013
Eur J Nucl Med Mol Imaging. 2015 May;42(6):818-30
pubmed: 25673053
Semin Oncol. 2011 Feb;38(1):26-41
pubmed: 21362514
Biochim Biophys Acta. 2010 Jan;1805(1):105-17
pubmed: 19931353
Nat Rev Cancer. 2004 Nov;4(11):891-9
pubmed: 15516961
NPJ Breast Cancer. 2022 Sep 26;8(1):111
pubmed: 36163365
Biomed Opt Express. 2015 Jan 15;6(2):559-73
pubmed: 25780745
J Nucl Med. 2017 Jul;58(7):1037-1042
pubmed: 27856630
J Natl Cancer Inst. 2015 Mar 30;107(6):djv048
pubmed: 25825511
Cancer Cell. 2013 Feb 11;23(2):143-58
pubmed: 23352126
Appl Radiat Isot. 2018 Oct;140:278-288
pubmed: 30081351
BME Front. 2023 Jan 13;4:0005
pubmed: 37849673
Eur J Cancer. 2014 Jul;50(11):1864-71
pubmed: 24841218
Cell. 2020 Nov 12;183(4):860-874
pubmed: 33186528
J Nucl Med. 2020 Aug;61(8):1187-1194
pubmed: 31862799
Neoplasia. 2015 Dec;17(12):862-870
pubmed: 26696368
NPJ Breast Cancer. 2020 Oct 16;6:54
pubmed: 33088912
Cancer Cell. 2015 Mar 9;27(3):354-69
pubmed: 25759021
NMR Biomed. 2019 Oct;32(10):e3943
pubmed: 29938857
Front Oncol. 2020 Mar 06;10:281
pubmed: 32211323
NPJ Breast Cancer. 2021 Apr 6;7(1):38
pubmed: 33824328
Sci Transl Med. 2014 Jun 11;6(240):240ra75
pubmed: 24920661
J Nucl Med. 2016 Feb;57 Suppl 1:34S-9S
pubmed: 26834099
Metabolites. 2021 Apr 27;11(5):
pubmed: 33925445
Cell Metab. 2017 Oct 3;26(4):633-647.e7
pubmed: 28978427
Cell Metab. 2021 Sep 7;33(9):1777-1792.e8
pubmed: 34375613
Nat Commun. 2015 Dec 10;6:8752
pubmed: 26658462
Breast Cancer. 2018 May;25(3):334-342
pubmed: 29357023
Cancer Res. 2017 Dec 15;77(24):7109-7119
pubmed: 29021136
Cancer Res. 2008 Oct 1;68(19):7985-94
pubmed: 18829556
Nat Commun. 2016 Oct 10;7:13041
pubmed: 27721378
Br J Cancer. 2011 May 24;104(11):1730-8
pubmed: 21559013
Cancer Biother Radiopharm. 2019 Feb;34(1):13-23
pubmed: 30351218
Cancer Biol Med. 2020 Feb 15;17(1):44-59
pubmed: 32296576
Mol Imaging Biol. 2006 Jan-Feb;8(1):36-42
pubmed: 16362149
Sci Rep. 2018 Mar 8;8(1):4171
pubmed: 29520098
Biochem Pharmacol. 2014 Nov 1;92(1):62-72
pubmed: 25107705
Oncotarget. 2017 Jun 13;8(24):38294-38308
pubmed: 28418843
Cell Rep. 2017 May 16;19(7):1313-1321
pubmed: 28514652
J Nucl Med. 2012 Feb;53(2):249-54
pubmed: 22241914
Cancer Res. 2021 Nov 1;81(21):5572-5581
pubmed: 34518211
BMC Biol. 2022 Jul 15;20(1):163
pubmed: 35840963
Clin Cancer Res. 2005 Apr 15;11(8):2785-808
pubmed: 15837727
Quant Imaging Med Surg. 2019 Oct;9(10):1731-1746
pubmed: 31728315
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19494-9
pubmed: 18042710
Mol Cell. 2022 Sep 1;82(17):3270-3283.e9
pubmed: 35973426
NPJ Breast Cancer. 2021 Mar 11;7(1):26
pubmed: 33707440
PLoS One. 2014 Mar 04;9(3):e90746
pubmed: 24595244
Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):377-85
pubmed: 25432784
Clin Nucl Med. 2021 Nov 1;46(11):896-903
pubmed: 34606485
Eur J Nucl Med Mol Imaging. 2007 Sep;34(9):1339-47
pubmed: 17333178
Biomedicines. 2022 Feb 23;10(3):
pubmed: 35327325
Eur J Nucl Med Mol Imaging. 2021 Dec;48(13):4396-4414
pubmed: 34173007
Mol Cancer Res. 2019 Dec;17(12):2492-2507
pubmed: 31537618
J Clin Invest. 2011 Oct;121(10):3786-8
pubmed: 21965334
J Nucl Med. 2023 May;64(5):717-723
pubmed: 36396458
Clin Cancer Res. 2010 Aug 15;16(16):4236-45
pubmed: 20682702
Front Oncol. 2020 Mar 10;10:304
pubmed: 32211331
Nucl Med Commun. 2010 Jun;31(6):604-9
pubmed: 20429097
Tumour Biol. 2013 Jun;34(3):1699-712
pubmed: 23443971
Indian J Nucl Med. 2015 Apr-Jun;30(2):145-7
pubmed: 25829734
Eur J Nucl Med Mol Imaging. 2004 Dec;31(12):1659-72
pubmed: 15565331
Med. 2021 Jun 11;2(6):736-754
pubmed: 34223403
Eur J Cancer. 2016 Mar;55:81-97
pubmed: 26820682
Nat Med. 2013 Aug;19(8):1067-72
pubmed: 23832090
Br J Cancer. 2013 Feb 19;108(3):479-85
pubmed: 23299535
Nature. 2019 Nov;575(7782):380-384
pubmed: 31666695
J Nucl Med. 2016 Sep;57(9):1329-30
pubmed: 27199361
Phys Med Biol. 2013 Jan 21;58(2):187-203
pubmed: 23257054
Biomol Ther (Seoul). 2018 Jan 1;26(1):81-92
pubmed: 29212309
Clin Cancer Res. 2011 Dec 15;17(24):7664-72
pubmed: 22028493
Cell Microbiol. 2004 Apr;6(4):303-17
pubmed: 15009023
Sci Transl Med. 2019 Apr 17;11(488):
pubmed: 30996079
Med Eng Phys. 2014 Mar;36(3):294-9
pubmed: 24331468
J Nucl Med. 2013 Nov;54(11):1946-53
pubmed: 24009277
Mol Cancer. 2010 Feb 09;9:33
pubmed: 20144215
Cell Death Dis. 2018 Feb 12;9(2):213
pubmed: 29434213
Ann Nucl Med. 2021 Dec;35(12):1321-1331
pubmed: 34436740
Oncotarget. 2018 May 29;9(41):26406-26416
pubmed: 29899867
Int J Cancer. 2019 Oct 15;145(8):2267-2281
pubmed: 30860605
Cancer Cell. 2018 May 14;33(5):905-921.e5
pubmed: 29763624
Cancer Discov. 2017 Apr;7(4):391-399
pubmed: 28255083
PLoS One. 2017 Aug 8;12(8):e0182689
pubmed: 28792505
Ann N Y Acad Sci. 2015 Sep;1350:1-16
pubmed: 26375862
Breast Cancer Res Treat. 2009 Feb;113(3):509-17
pubmed: 18327670
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):
pubmed: 33452133
Front Oncol. 2022 May 25;12:854658
pubmed: 35692767
Oncogene. 2023 Mar;42(14):1117-1131
pubmed: 36813854
Cell Metab. 2018 Jan 9;27(1):136-150.e5
pubmed: 29249690
Cell Rep. 2017 Jan 17;18(3):601-610
pubmed: 28099841
Cancer Res. 2019 Jul 15;79(14):3557-3569
pubmed: 31088837
Arch Biochem Biophys. 2014 Mar 1;545:69-73
pubmed: 24393743
Nature. 2022 May;605(7911):747-753
pubmed: 35585241
Nat Med. 2018 Jul;24(7):1036-1046
pubmed: 29892070
Mol Imaging Biol. 2022 Feb;24(1):126-134
pubmed: 34383241
Am J Nucl Med Mol Imaging. 2015 Oct 12;5(5):431-56
pubmed: 26550536
Nucl Med Commun. 2012 Feb;33(2):191-7
pubmed: 22107997
J Magn Reson Imaging. 2017 Jul;46(1):290-302
pubmed: 27981651
Eur J Nucl Med Mol Imaging. 2018 Jul;45(8):1279-1288
pubmed: 29616304
Cancers (Basel). 2021 Jan 05;13(1):
pubmed: 33466329
J Clin Oncol. 2001 Jun 1;19(11):2797-803
pubmed: 11387350
Cell. 2012 Apr 27;149(3):656-70
pubmed: 22541435
Cancer Res. 2008 Oct 15;68(20):8607-15
pubmed: 18922937
Mol Metab. 2020 May;35:100962
pubmed: 32244187
J Hematol Oncol. 2022 Apr 27;15(1):45
pubmed: 35477416
J Clin Oncol. 2008 Mar 10;26(8):1275-81
pubmed: 18250347
Nat Metab. 2020 Apr;2(4):318-334
pubmed: 32691018
Breast Cancer. 2021 Jan;28(1):82-91
pubmed: 32671723
J Clin Invest. 2011 Jul;121(7):2750-67
pubmed: 21633166
Magn Reson Imaging. 2012 Nov;30(9):1203-15
pubmed: 22819579
J Clin Med. 2022 Aug 03;11(15):
pubmed: 35956129
Trends Endocrinol Metab. 2021 Oct;32(10):762-775
pubmed: 34340886
J Nucl Med. 2015 Nov;56(11):1681-9
pubmed: 26359256
J Biomed Opt. 2020 May;25(7):1-43
pubmed: 32406215
Cell. 2016 Feb 11;164(4):681-94
pubmed: 26853473
Semin Nucl Med. 2007 Nov;37(6):429-39
pubmed: 17920350
Tumori. 2015 Mar 20;101(1):e9-e12
pubmed: 25702650
Ann Surg Oncol. 2014 Jul;21(7):2165-71
pubmed: 24558065
J Clin Exp Hepatol. 2015 Dec;5(4):320-8
pubmed: 26900274
Indian J Med Res. 2015 Dec;142(6):721-31
pubmed: 26831421
Clin Cancer Res. 2017 Mar 15;23(6):1432-1441
pubmed: 27587436
PLoS Biol. 2020 Nov 13;18(11):e3000872
pubmed: 33186350
Nat Ecol Evol. 2019 Nov;3(11):1539-1551
pubmed: 31611676
Eur J Nucl Med Mol Imaging. 2019 Feb;46(2):501-518
pubmed: 30269154