Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
23 06 2023
23 06 2023
Historique:
medline:
23
6
2023
pubmed:
21
6
2023
entrez:
21
6
2023
Statut:
ppublish
Résumé
Fibrolamellar hepatocellular carcinoma (FLC) is a usually lethal primary liver cancer driven by a somatic dysregulation of protein kinase A. We show that the proteome of FLC tumors is distinct from that of adjacent nontransformed tissue. These changes can account for some of the cell biological and pathological alterations in FLC cells, including their drug sensitivity and glycolysis. Hyperammonemic encephalopathy is a recurrent problem in these patients, and established treatments based on the assumption of liver failure are unsuccessful. We show that many of the enzymes that produce ammonia are increased and those that consume ammonia are decreased. We also demonstrate that the metabolites of these enzymes change as expected. Thus, hyperammonemic encephalopathy in FLC may require alternative therapeutics.
Identifiants
pubmed: 37343102
doi: 10.1126/sciadv.adg7038
pmc: PMC10284549
doi:
Substances chimiques
Proteome
0
Ammonia
7664-41-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadg7038Subventions
Organisme : NCI NIH HHS
ID : P50 CA210964
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007739
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA243126
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Références
Eur J Pediatr. 1980 Aug;134(2):109-13
pubmed: 7439194
Nature. 2020 Dec;588(7839):712-716
pubmed: 33328633
Anticancer Res. 2004 Sep-Oct;24(5A):2893-6
pubmed: 15517893
J Gastrointest Oncol. 2019 Jun;10(3):582-588
pubmed: 31183212
J Biol Chem. 1957 May;226(1):497-509
pubmed: 13428781
Sci Adv. 2019 May 22;5(5):eaaw4543
pubmed: 31131326
Cell Metab. 2021 Jan 5;33(1):211-221.e6
pubmed: 33152324
Neural Comput. 2021 Oct 12;33(11):2881-2907
pubmed: 34474477
Cancer Res Treat. 2021 Jan;53(1):283-288
pubmed: 32898940
Front Oncol. 2020 Mar 02;10:159
pubmed: 32195169
Nat Rev Cancer. 2018 Jul;18(7):452-464
pubmed: 29643473
Case Reports Hepatol. 2018 Dec 9;2018:7521986
pubmed: 30631612
Hepatol Commun. 2022 Dec;6(12):3539-3549
pubmed: 36245434
Sci Rep. 2022 Nov 5;12(1):18807
pubmed: 36335239
JCI Insight. 2022 Sep 8;7(17):
pubmed: 36073545
Hum Mutat. 2006 Jul;27(7):626-32
pubmed: 16786505
United European Gastroenterol J. 2013 Oct;1(5):351-7
pubmed: 24917983
J Pediatr Surg. 2015 Jan;50(1):153-6
pubmed: 25598114
Oncologist. 2016 Apr;21(4):514-20
pubmed: 26975868
Clin Cancer Res. 2023 Jan 4;29(1):271-278
pubmed: 36302174
Scientifica (Cairo). 2012;2012:743790
pubmed: 24278737
Arch Dis Child. 2001 Jan;84(1):84-88
pubmed: 11124797
Cancer Discov. 2021 Oct;11(10):2544-2563
pubmed: 34127480
Nature. 1986 Oct 16-22;323(6089):643-6
pubmed: 2877398
Nucleic Acids Res. 2021 Jan 8;49(D1):D1541-D1547
pubmed: 33174596
Am J Med Sci. 2009 Dec;338(6):522-4
pubmed: 20010160
Annu Rev Pharmacol Toxicol. 2016;56:85-102
pubmed: 26514196
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4459-64
pubmed: 15753290
Oncotarget. 2015 Jan 20;6(2):755-70
pubmed: 25605237
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E5916-25
pubmed: 26489647
Cell. 2016 Jul 28;166(3):555-566
pubmed: 27471965
Pediatr Blood Cancer. 2018 Dec;65(12):e27392
pubmed: 30094907
Nucleic Acids Res. 2021 Jul 2;49(W1):W388-W396
pubmed: 34019663
Nat Chem Biol. 2020 Dec;16(12):1351-1360
pubmed: 32778843
Hepatology. 2021 Nov;74(5):2899-2901
pubmed: 34105830
Cancer Cell. 2013 Aug 12;24(2):213-228
pubmed: 23911236
Hepatology. 2017 Jan;65(1):281-293
pubmed: 27641632
Proc Natl Acad Sci U S A. 1971 Apr;68(4):820-3
pubmed: 5279523
Clin Mol Hepatol. 2020 Jan;26(1):74-77
pubmed: 31422648
Science. 2014 Feb 28;343(6174):1010-4
pubmed: 24578576
Am J Med Sci. 2020 Apr;359(4):242-244
pubmed: 32014302
Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5521-6
pubmed: 25870278
Mol Biol Cell. 2019 Mar 15;30(6):733
pubmed: 30870095
J Proteome Res. 2020 Apr 3;19(4):1447-1458
pubmed: 31984744
Semin Liver Dis. 2018 Feb;38(1):51-59
pubmed: 29471565
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13076-13084
pubmed: 29162699
J Pain Symptom Manage. 2014 Apr;47(4):e5-7
pubmed: 24731681
ACG Case Rep J. 2016 Aug 17;3(4):e106
pubmed: 27807568
Oncotarget. 2017 Dec 15;9(12):10211-10227
pubmed: 29535801
JIMD Rep. 2014;16:47-50
pubmed: 24997132
Nat Protoc. 2018 Jul;13(7):1632-1661
pubmed: 29988108
Gastroenterology. 2017 Dec;153(6):1662-1673.e10
pubmed: 28923495
J Biol Chem. 1991 Jan 15;266(2):752-8
pubmed: 1845993
Am J Case Rep. 2017 Mar 08;18:234-241
pubmed: 28270654
J Proteome Res. 2018 May 4;17(5):1934-1942
pubmed: 29635916