Clinical outcomes of endoscopic submucosal dissection for esophageal squamous cell carcinoma with esophageal varices: Multicenter retrospective study.
endoscopic submucosal dissection
esophageal squamous cell carcinoma
esophageal varices
liver cirrhosis
Journal
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
ISSN: 1443-1661
Titre abrégé: Dig Endosc
Pays: Australia
ID NLM: 9101419
Informations de publication
Date de publication:
21 Jun 2023
21 Jun 2023
Historique:
received:
25
04
2023
accepted:
20
06
2023
pubmed:
21
6
2023
medline:
21
6
2023
entrez:
21
6
2023
Statut:
aheadofprint
Résumé
Clinical outcomes of endoscopic submucosal dissection (ESD) for esophageal squamous cell carcinoma (ESCC) with esophageal varices (EVs) are obscure. We aimed to elucidate the clinical outcomes of ESD for ESCC with EVs in a multicenter, retrospective study. We established a retrospective cohort of 30 patients with ESCC complicating EVs, who underwent ESD at 11 Japanese institutions. Rates of en bloc resection and R0 resection, procedure time, and adverse events were evaluated as indicators of the feasibility and safety of ESD. Additional treatment, recurrence, and metastasis of the lesions were evaluated as indicators of the long-term efficacy of ESD. Portal hypertension was caused by cirrhosis, of which alcohol was the most common cause. En bloc resection was achieved in 93.3% and R0 resection in 80.0% of the patients. The median procedure time was 92 min. Adverse events included a case of uncontrolled intraoperative bleeding leading to discontinuation of ESD and a case of esophageal stricture due to extensive resection. During the follow-up period of a median for 42 months, a patient with local recurrence and another patient with liver metastasis were observed. One patient died of liver failure after receiving chemoradiotherapy as an additional treatment after ESD. No patient died of ESCC. This multicenter, retrospective cohort study demonstrated the safety and efficacy of ESD for ESCC with EVs. Further studies are needed to establish appropriate treatment methods for EVs before ESD and additional treatments for patients with insufficient ESD.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Risaburo Akasaka
(R)
Hiroko Abe
(H)
Tatsuya Mikami
(T)
Daisuke Chinda
(D)
Hidezumi Kikuchi
(H)
Tsunetaka Kato
(T)
Minami Hashimoto
(M)
Takumi Yanagita
(T)
Shoichiro Fujishima
(S)
Informations de copyright
© 2023 Japan Gastroenterological Endoscopy Society.
Références
Oyama T, Tomori A, Hotta K et al. Endoscopic submucosal dissection of early esophageal cancer. Clin Gastroenterol Hepatol 2005; 3: S67-70.
Fujishiro M, Yahagi N, Kakushima N et al. Endoscopic submucosal dissection of esophageal squamous cell neoplasms. Clin Gastroenterol Hepatol 2006; 4: 688-94.
Kawashima K, Abe S, Koga M et al. Optimal selection of endoscopic resection in patients with esophageal squamous cell carcinoma: Endoscopic mucosal resection versus endoscopic submucosal dissection according to lesion size. Dis Esophagus 2021; 34: doaa096.
Min YW, Lee H, Song BG et al. Comparison of endoscopic submucosal dissection and surgery for superficial esophageal squamous cell carcinoma: A propensity score-matched analysis. Gastrointest Endosc 2018; 88: 624-33.
Zhang Y, Ding H, Chen T et al. Outcomes of endoscopic submucosal dissection vs esophagectomy for T1 esophageal squamous cell carcinoma in a real-world cohort. Clin Gastroenterol Hepatol 2019; 17: 73-81.e3.
Minashi K, Nihei K, Mizusawa J et al. Efficacy of endoscopic resection and selective chemoradiotherapy for stage I esophageal squamous cell carcinoma. Gastroenterology 2019; 157: 382-90.e3.
Hatta W, Koike T, Takahashi S et al. Risk of metastatic recurrence after endoscopic resection for esophageal squamous cell carcinoma invading into the muscularis mucosa or submucosa: A multicenter retrospective study. J Gastroenterol 2021; 56: 620-32.
Alqahtani SA, Jang S. Pathophysiology and management of variceal bleeding. Drugs 2021; 81: 647-67.
Liu YB, Chen MK. Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions. World J Gastroenterol 2022; 28: 5910-30.
Sawaguchi M, Jin M, Matsuhashi T et al. The feasibility of endoscopic submucosal dissection for superficial esophageal cancer in patients with cirrhosis (with video). Gastrointest Endosc 2014; 79: 681-5.
Choi YK, Noh JH, Kim DH et al. Outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms in patients with liver cirrhosis. Clin Endosc 2022; 55: 381-9.
Zhang S, Liu YD, Chai NL et al. Endoscopic submucosal dissection for early cancers or precancerous lesions of the upper gastrointestinal tract in cirrhotic patients with esophagogastric varices: Ten-year experience from a large tertiary center in China. Gastrointest Endosc 2023; 97: 1031-44.
Oken MM, Creech RH, Tormey DC et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982; 5: 649-55.
Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987; 40: 373-83.
Japan Esophageal Society. Japanese classification of esophageal cancer, 11th edition: Part I. Esophagus 2017; 14: 1-36.
Tajiri T, Yoshida H, Obara K et al. General rules for recording endoscopic findings of esophagogastric varices (2nd edition). Dig Endosc 2010; 22: 1-9.
Yeh JH, Huang RY, Lee CT et al. Long-term outcomes of endoscopic submucosal dissection and comparison to surgery for superficial esophageal squamous cancer: A systematic review and meta-analysis. Therap Adv Gastroenterol 2020; 13: 1756284820964316.
Yoshida M, Takizawa K, Nonaka S et al. Conventional versus traction-assisted endoscopic submucosal dissection for large esophageal cancers: A multicenter, randomized controlled trial (with video). Gastrointest Endosc 2020; 91: 55-65.e2.
Furuichi Y, Gotoda T, Moriyasu F et al. Dual red imaging (novel advanced endoscopy) can increase visibility and can predict the depth in diagnosing esophageal varices. J Gastroenterol 2017; 52: 568-76.
Miyazaki K, Kato M, Matsuura N, Kanai T, Yahagi N. Esophageal endoscopic submucosal dissection on postendoscopic variceal ligation scars with injection under red dichromatic imaging. VideoGIE 2021; 6: 536-9.
Kikuchi A, Toya Y, Fujino Y, Yanai S, Matsumoto T. Endoscopic submucosal dissection with red dichromatic imaging for esophageal squamous cell carcinoma after endoscopic variceal sclerotherapy. Endoscopy 2023; 55: E120-1.
Valmasoni M, Pierobon ES, De Pasqual CA et al. Esophageal cancer surgery for patients with concomitant liver cirrhosis: A single-center matched-cohort study. Ann Surg Oncol 2017; 24: 763-9.
Trivin F, Boucher E, Vauléon E et al. Management of esophageal carcinoma associated with cirrhosis: A retrospective case-control analysis. J Oncol 2009; 2009: 173421.